55 results about "Helix structure" patented technology

The invention provides a recombinant XVII type collagen with a triple helix structure, and belongs to the technical field of biological proteins. The amino acid sequence of the collagen comprises one or more amino acid residue repetitive units, each repetitive unit comprises a sequence as shown in SEQ ID NO.1 or SEQ ID NO.2, the number of repetitions is n, and n is larger than 1 and smaller than or equal to 60. The recombinant XVII type collagen provided by the invention is simple in production process, relatively high in expression quantity, low in immunogenicity, high in safety, relatively good in stability of the triple-helix structure, and strong in supporting capacity for skin cells; efficacy experiments show that the collagen has higher cell adhesion, wound healing promotion and hair follicle repair promotion capability than XVII type collagen products in the market at present, and can be widely applied to the fields of food, health care products, cosmetics, medical instruments and the like.

The invention provides recombinant VIII type humanized collagen and application thereof, and the recombinant VIII type humanized collagen is of a triple helix structure, has good cell adhesion activity, does not generate immunological rejection and anaphylactic reaction when being applied to a human body, is a brand new human body synthetic biological material, and has good application prospects.

A method for secure quantum communication includes generating a photon. The method includes modulating at least two quantum state dimensions selected from the group consisting of orbital angular momentum (OAM), polarization, and phase of the photon to form a composite quantum state. The method includes directing the photon to an emission point on a helical structure having a defined spatial coordinate corresponding to classical data. The method includes emitting the photon from the emission point into a quantum channel. The composite quantum state and spatial coordinate together encode secure information.

The invention belongs to the technical field of building construction, and discloses a double-helix structure system and a construction method.The double-helix structure system comprises a core column, a first inner spiral body, a second inner spiral body, a first outer spiral body and a second outer spiral body, and the first inner spiral body and the second inner spiral body adopt curved concrete thick shells; the first inner spiral body and the second inner spiral body are both connected with the core column and spirally ascend to the top of the core column from the two opposite sides of the bottom of the core column. The first outer spiral body is rigidly connected with the overhanging end of the first inner spiral body, the first outer spiral body comprises a plurality of overhanging prefabricated UHPC beams, and the adjacent overhanging prefabricated UHPC beams are connected through split bolts and form steps; the second outer spiral body is in rigid connection with the overhanging end of the second inner spiral body, the orthographic projection of the second outer spiral body in the ground direction is larger than that of the first outer spiral body in the ground direction, the second outer spiral body is of a steel frame structure, and the steel frame structure is provided with a supporting column supported on the ground.

The invention discloses a micro-fluidic chip for sorting circulating tumor cells based on a double-helix structure and a sorting method thereof, the micro-fluidic chip has the double-helix structure comprising an inner outlet, and the micro-fluidic chip comprises a primary screening channel for primarily focusing and separating circulating tumor cells; the secondary screening channel is directly connected with the primary screening channel and is used for carrying out secondary focusing separation on the circulating tumor cells subjected to primary screening; wherein the primary screening channel is separated into two branches after rotating into the chip, one branch is connected with the middle outlet and used for discharging unfocused particles and redundant liquid, and the other branch is connected with the secondary screening channel so as to continue focusing and separation of the particles; the micro-fluidic chip is provided with an inlet for injecting a liquid sample and three outlets, namely a middle outlet, a particle collection outlet and a waste outlet, so that the injection of the liquid sample and the collection of separated particles are realized. According to the invention, high-throughput screening of the circulating tumor cells is realized, and the separation efficiency is improved.

Provided in the present application is a recombinant type XVII collagen having a triple helix structure. The collagen has an amino acid sequence containing one or more amino acid residue repeating units, wherein each of the repeating units contains a sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2, and the repetition number is n, where 1＜n≤60. The recombinant type XVII collagen provided in the present application can be used in the fields of food, health care products, cosmetics, medical instruments, etc.

The present disclosure provides recombinant type XVII collagen having a triple helix structure and uses thereof, which belong to the field of protein engineering technology. The recombinant type XVII collagen has an amino acid sequence formed by tandem repeats of n or more core units, where n is an integer of 1 or more, and the core unit has the amino acid sequence shown in SEQ ID NO: 1. The present disclosure also provides methods for constructing multiple expression systems and methods for preparing recombinant type XVII collagen. provide.

The present invention belongs to the field of biological detection technology, and specifically relates to a method for detecting the integrity of the collagen triple helix structure using collagen peptide-coated metal nanoclusters and disulfide nanomaterials. The method comprises: 1) obtaining collagen peptide-coated metal nanoclusters; 2) mixing the collagen peptide-coated metal nanoclusters with a disulfide solution; 3) mixing the mixture obtained in step 2) with a collagen standard and a collagen sample to be tested, respectively, and measuring the maximum fluorescence intensity within the range of 360nm-550nm under an excitation wavelength of 340nm, respectively, denoted as F 标 、F A , compared with the fluorescence intensity F0 of the blank system, the integrity of the triple helix structure in the sample = (F A ‑F0) / (F 标 The detection method provided by the present invention has the advantages of simple operation, high sensitivity, and short detection time; it can be used to detect the integrity of the triple helix structure of almost all type I collagen on the market, with a wide detection range.

The invention discloses a forming method, a forming device and a mounting method of a double-helix structure workpiece, and belongs to the technical field of molds, the forming method comprises the following steps: designing a mold of the forming device: performing three-dimensional modeling based on related parameters of the double-helix structure workpiece to obtain a double-helix structure workpiece model; the contour pitch diameter size of the double-helix structure workpiece model is obtained, three-dimensional modeling is carried out, a double-helix groove is generated based on Boolean subtraction, and an inner mold model and an outer mold model are obtained; and forming of a double-helix structure workpiece: arranging a soft linear part along the outer wall of the inner mold model, combining and aligning the outer mold model and the inner mold model, and then connecting and fixing the outer mold model and the inner mold model, so that the soft linear part is subjected to standing forming, and the double-helix structure workpiece is obtained. Rapid forming and assembling of the double-spiral-structure workpiece can be achieved, forming and assembling consistency of the double-spiral-structure workpiece is guaranteed, the percent of pass and production efficiency are improved, mounting and dismounting are convenient, and operability is high.

A methane and hydrogen mixer with a bionic DNA (deoxyribonucleic acid) double-helix structure relates to the technical field of hydrogen energy utilization, and through the DNA double-helix structure formed by two spiral columns and a guide plate, methane and hydrogen can be more fully contacted and mixed in the mixer, so that the mixing uniformity is improved. Meanwhile, the bionic DNA double-helix structure can optimize a fluid channel and flow velocity distribution in the mixing element, so that the fluid resistance is reduced, the energy loss in the mixing process is reduced, and the energy efficiency of the whole system is improved.

This invention discloses a biomimetic anchoring device based on a double-helix structure and an active adhesion mechanism, belonging to the technical field of biomimetic and marine engineering mooring equipment. Addressing the shortcomings of existing deep-water mooring anchors, such as large soil disturbance and easy failure of passive pull-out resistance, this invention provides a biomimetic anchoring structure adapted to complex seabed sediments. The device includes a rigid body, double-helix blades, and an active adhesion triggering mechanism. The rigid body consists of a solid bullet head, a central oval hollow structure, and a top conical structure. The double-helix blades adopt a variable pitch and variable diameter design, with evenly distributed grooves on the surface. The active adhesion triggering mechanism includes an anchor ring and an anchor ring piston structure, with a built-in drive motor and intelligent sensing and control module in the center. The device achieves low-disturbance penetration through double-helix micro-screwing and kinematic matching. Active adhesion is triggered under tension, forming a deep mechanical interlock and high-pressure consolidated soil crust with the soil, significantly improving pull-out bearing capacity. It is suitable for complex seabed sediments such as soft mud and gravel mixtures.

The invention discloses recombinant collagen with a triple helix structure as well as a preparation method and application of the recombinant collagen, and belongs to the technical field of biochemical engineering. The recombinant collagen with the triple helix structure provided by the invention comprises at least one of CAIII81C, CAIII142C and CAIII405C, and the recombinant collagen with the triple helix structure comprises at least one of CAIII81C, CAIII142C and CAIII405C, the amino acid sequence of the CAIII81C is as shown in SEQ ID NO: 1, the amino acid sequence of the CAIII142C is as shown in SEQ ID NO: 2, and the amino acid sequence of the CAIII405C is as shown in SEQ ID NO: 3. The eukaryotic expression system realizes the expression of the recombinant collagen CAIII81C, CAIII142C and CAIII405C with the triple helix structure, and the triple helix structure stably exists at the temperature of 65 DEG C. An activity experiment result of mouse embryo fibroblast (BALB / c 3T3) migration shows that the recombinant collagen CAIII81C, the recombinant collagen CAIII142C and the recombinant collagen CAIII405C expressed by the invention have very good activity of promoting cell migration.

Provided is a large-scale biological method for preparing collagen having 164.88° triple helix structure. Provided is a method for constructing a yeast cell expressing collagen, comprising introducing a recombinant expression vector into the yeast cell, wherein the recombinant expression vector comprises a polynucleotide encoding the collagen, wherein the collagen comprises repeating units of the sequence as shown in SEQ ID No. 1, the number of the repeating units is 2-32, and the repeating units are directly linked. The collagen is recombinant type III humanized collagen, preferably collagen having a 164.88° triple helix structure. The present disclosure achieves large-scale production of a recombinant humanized collagen which has a 164.88° triple helix structure and belongs to type A by engineering a "chassis strain", and can meet the market demand through large-scale production.

The utility model relates to the technical field of electrode leads, in particular to an implantable cardiac pacemaker electrode lead. The implantable cardiac pacemaker electrode lead comprises a catheter, a catheter separation layer which divides the interior of the catheter into two cavities is arranged in the catheter, a first spiral is arranged in one cavity, a second spiral is arranged in the other cavity, a first insulating tube is arranged on the outer side of the first spiral, and a second insulating tube is arranged on the outer side of the second spiral. One end of the screw I is welded with the connecting ring I, the other end of the screw I is welded with the cathode, one end of the screw II is welded with the connecting ring II, the other end of the screw II is welded with the anode, the welding part of one end of the screw I and the connecting ring I is provided with a sealing ring I, the welding part of the other end of the screw I and the cathode is provided with barbs, and the welding part of one end of the screw II and the connecting ring II is provided with a sealing ring II. The first connecting ring, the second connecting ring, the cathode and the anode of the implantable cardiac pacemaker electrode wire are not changed, the catheter structure and the spiral structure are changed, the catheter separation layer is additionally arranged in the middle of the catheter, the first spiral and the second spiral can be effectively separated, and the safety and stability performance is improved.

The invention discloses a thrombectomy stent and a thrombectomy device.The thrombectomy stent is of a self-expansion structure, the thrombectomy stent comprises a stent body, the stent body comprises a first screw rod, a second screw rod and at least five supporting structures, and the first screw rod and the second screw rod form a reverse double-helix structure; the first screw rod and the second screw rod are fixedly connected at a near-end connecting point and a far-end connecting point respectively, the near-end connecting point is close to the operation end, and the far-end connecting point is far away from the operation end; each supporting structure is fixedly connected with the first screw rod and the second screw rod, the at least five supporting structures are arranged at intervals, each supporting structure comprises at least one V-shaped structure, and an opening of each V-shaped structure faces the operation end. By means of the thrombectomy support, effective radial supporting force can be provided, the support can be conveniently cut, the thrombectomy blocks can be conveniently embedded, the thrombectomy blocks can be effectively captured, and the thrombectomy effect and the thrombectomy efficiency are improved; and meanwhile, the structure is simple, and the good storage and conveying performance is achieved.

The present application is suitable for the technical field of spiral layered structure, and provides a suture-spiral composite plate bionic energy absorption structure which combines the advantages of layered spiral structure and suture structure. The structure comprises: a plurality of unit layer groups, each unit layer group comprising a plurality of unit layers, the plurality of unit layer groups being periodically arranged along the layering direction. According to the principle of bionics, the method of similarity analysis is used to confirm that the core is to compare the chitinous suture structure in the iron beetle with the selected elements to bionically generate a new energy absorption structure from the angles of structural similarity, functional similarity and boundary similarity. According to the structural feature extraction and spiral structure fusion of the chitinous characteristics in the iron beetle, a three-dimensional macroscopic preliminary suture-spiral composite plate bionic structure is established, and the range of each element and its size is determined for structure construction and size parameter optimization. The present application can reduce the mass of parts and improve the energy absorption efficiency.

A chain has: a multitude of first links that are pivotally connected to each other and form a first helical link connection that extends helically; a multitude of second links that are pivotally connected to each other and form a second helical link connection that extends helically; and a multitude of connecting components that link the first links and the second links, which correspond one-to-one to the first links, to connect the first helical link connection and the second helical link connection and to form a double helix structure.

The invention belongs to the technical field of bioengineering, particularly relates to a triple-helix structure recombinant humanized three-type collagen as well as a production method and application thereof, particularly discloses the triple-helix structure recombinant humanized three-type collagen, and also discloses a gene for coding the recombinant humanized three-type collagen, and a preparation method of the triple-helix structure recombinant humanized three-type collagen. The invention also discloses an engineering bacterium for producing the recombinant humanized three-type collagen. The invention further discloses a preparation method of the recombinant humanized three-type collagen with the triple-helix structure and application of the recombinant humanized three-type collagen in the fields of biomedical materials, beauty cosmetics, skin care products, medical apparatuses and instruments and the like. Results of the embodiment show that the triple-helix recombinant humanized III-type collagen provided by the invention has the capability of promoting cell proliferation, is free of cytotoxicity and high in cell adhesion activity, and experiments prove that the triple-helix recombinant humanized III-type collagen has a triple-helix structure characterized by collagen.

A magnet assembly (10) comprises a shaft (20) and first and second helical formations (28, 30) on the shaft (20). An additional part (40) is provided on the first and second helical formations (28, 30), the additional part (40) comprising a magnetic material.

The invention provides a device and a method for detecting the starting point size of a fixed-starting-point spiral structure. The detection device comprises a base, a mandrel, a clamping assembly and a measuring assembly. And the mandrel passes through a workpiece to be detected. In the clamping assembly, an axial clamping assembly comprises two positioning plates and a first jacking screw, the positioning plates are fixed to the base and support the two ends of the mandrel, and the first jacking screw penetrates through one positioning plate to axially jack a workpiece on the other positioning plate; the radial clamping assembly comprises two stand columns, a pressing plate and a second jacking screw, the pressing plate is connected to the base through the stand columns, and the second jacking screw penetrates through the pressing plate to jack the workpiece to the base in the radial direction. In the measuring assembly, a through sample column, a stop sample column, a distance measuring seat and an angle measuring seat can detect whether the spiral section distance and the spiral included angle of the spiral structure of the workpiece are qualified or not, wherein the distance measuring seat and the angle measuring seat correspond to thread heads of the workpiece in number. According to the invention, screwing of a spiral gauge and the spiral structure is avoided, whether the starting point size of the fixed-starting-point spiral structure is qualified can be accurately measured, and the detection efficiency is high.

Provided is a low-molecular-weight collagen having a 164.88° triple-helix structure. The present invention relates to small-molecule collagen, a preparation method therefor, and a use thereof. The collagen has an amino acid sequence represented by SEQ ID NO: 1 or a variant amino acid sequence after mutation of the amino acid sequence. The variant amino acid sequence retains the function of the amino acid sequence represented by SEQ ID NO: 1. The collagen has a short amino acid sequence and good transdermal absorption performance.

The invention relates to the field of medical instruments, in particular to a flexible joint, flexible equipment, a flexible device, a mechanical arm and a surgical robot. The connector comprises an elastic main body, a first supporting part and a second supporting part, wherein the elastic main body comprises a first elastic part, a first connecting part and a contact part; the first elastic part is of a cylindrical spiral structure, and the two ends of the first elastic part are connected with the first supporting part and the second supporting part correspondingly. The moving point of the first elastic part at least corresponds to one first connecting part when rotating by 2 pi radian, the first connecting part corresponds to the contact part, and two ends of the first connecting part are respectively connected with the first elastic part and the contact part; the contact parts are located at the central axes of the first elastic parts, and when the first elastic parts are bent, the adjacent contact parts are in rolling connection. The mechanism has two bending degrees of freedom, and the control precision and stability are improved.

The disclosure relates to a brace, methods of preparation, and methods of using the brace. The brace comprises a plurality of first helix structures and a plurality of second helix structures. Each first helix winds in a first direction from a proximal end to a distal end, conforming to a contour of an object. Each second helix winds in a second direction from the proximal end to the distal end, also conforming to the contour of the object. Each first helix of the plurality of first helix structures is rotatably coupled to a corresponding second helix of the plurality of second helix structures, forming a helix pair. The first direction of the plurality of first helix structures opposes the second direction of the plurality of second helix structures.

To provide a synthetic peptide, in particular a conductive synthetic peptide with an alpha helix conformation used as a molecular wire in molecular electronics.SOLUTION: In various embodiments, a synthetic peptide used as a molecular wire in a molecular electronic circuit comprises an alpha helical segment further comprising repeating alpha helix motifs. The synthetic peptide may further comprise at least one specific conjugation site between the termini for attachment to 5 molecules such as a binding probe, and may further comprise termini having metal binding functionalities such as repeats of material binding sequences. In various aspects, the synthetic peptide comprises intramolecular hydrogen bonding, salt bridges, and optionally, aromatic rings that provide electrical conductivity through the peptide.SELECTED DRAWING: Figure 2

The spiral flat coil comprises a coil body, the coil body is of a spiral structure formed by winding a flat metal strip, one end of the metal strip is arranged inside the spiral structure, and the other end of the metal strip is arranged outside the spiral structure. And the screw extends into the spiral structure from the bottom of the spiral structure. The coil body is of a spiral structure formed by winding a flat metal strip, the coil is of a planar structure, three-dimensional winding is not needed, the size is reduced by 40%, the coil is suitable for high-density integration, meanwhile, the contact area of the magnetic body and the coil is large, the temperature heat dissipation performance of the coil is improved, and the vibration resistance and impact resistance of a product are excellent.

This invention relates to the fields of interfacial water evaporation, seawater desalination, and wastewater treatment, and discloses a solar evaporator with a double-helix lateral structure. The evaporator includes a substrate with water absorption and transport functions. The outer wall of the substrate is provided with a double-helix structure capable of actively inducing micro-air convection. The double-helix structure is an axially extending double-helix groove or double-helix protrusion. During evaporation, the double-helix structure can actively disrupt the stagnant air boundary layer, enhance the outward diffusion of water vapor, and reduce the saturated vapor pressure of the lateral surface, thereby significantly enhancing the evaporation rate of the lateral surface. The core of this invention lies in a unique, functional macroscopic geometric structure, which is an integral part of the evaporator body, rather than an external attachment.

The invention belongs to the technical field of mechanical metamaterials, and particularly relates to a super-configuration damping material and a preparation method and application thereof. The super-structure damping material provided by the invention comprises a plurality of super-structure damping material unit cells, each superstructure damping material unit cell comprises a viscous-elastic material layer, metal type local resonance units arranged on one surface of the viscous-elastic material layer in an array mode, any adjacent metal type local resonance units in the superstructure damping material unit cells are arranged at intervals, and fiber reinforced material layers are arranged between any adjacent metal type local resonance units. The viscoelastic material layer comprises a viscoelastic material; the metal type local resonance unit is provided with a double-spiral structure. The super-configuration damping material provided by the invention is at low frequency (lt; and the loss factor (eta) under the vibration (500 Hz) is greater than 0.3, so that the lightweight design can be realized.

This invention discloses a three-dimensional micromixer based on the DNA double helix structure, belonging to the field of microfluidics technology. The micromixer has two spatial helical channels with a π-phase difference, periodically coupled through staggered, "base pair"-like connecting channels. The centrifugal force generated by the three-dimensional helical microchannels induces Dean's vortexes, producing a "rotation-revolution" composite effect during fluid flow. Furthermore, the mass transfer between the two channels is enhanced through the splitting-recombination effect of the "base pair" connecting channels. Compared with existing technologies, this invention has the following advantages: 1. It induces complex three-dimensional flow through the three-dimensional DNA double helix structure, realizing continuous renewal and stretching of the fluid interface; 2. It utilizes the curvature and torsion of the three-dimensional helical structure to generate a "revolution" enhanced mixing effect under the superposition effect of rotation and deflection, forming a "rotation-revolution composite flow" similar to planetary motion, overcoming the mixing difficulties caused by low diffusion efficiency and difficulty in forming chaotic convection in high-viscosity oil phase systems; 3. Under the same mixing efficiency, the pressure drop of this device is much smaller than that of traditional two-dimensional planar serpentine and split-and-merge micromixers, enabling rapid and uniform mixing of high-viscosity fluids with low energy consumption, and is particularly suitable for mixing and mass transfer enhancement of high-viscosity oil phase systems in fine chemical processes.

The ablation catheter comprises a double-helix structure, a bendable section, a catheter body and a control handle which are sequentially connected from the far end to the near end. The double-spiral structure comprises a main spiral section and an auxiliary spiral section; the main spiral sections and the auxiliary spiral sections are distributed around the same axis in a staggered mode in the same direction. The far end of the auxiliary spiral section is connected with the far end of the main spiral section through a spiral section fixing piece, or the far end of the auxiliary spiral section is provided with the spiral section fixing piece, and the spiral section fixing piece is movably connected with the main spiral section; a plurality of electrodes are arranged on the main spiral section; a wire guide cavity and a wire guide cavity which are separately arranged are formed in the main spiral section; a shaping wire cavity is formed in the auxiliary spiral section; and shaping wires are arranged in the shaping wire cavities. By means of the configuration, under the condition that the spiral section is kept soft and not prone to damaging tissue, the supporting performance of the electrode area is enhanced, the effective attaching performance is improved, and meanwhile the treatment covering area is increased.

The utility model provides a bone tissue drilling device which is composed of an outer sleeve drill bit, a built-in drill bit, a drill rod and a clamping head, and the built-in drill bit is arranged inside the outer sleeve drill bit in a sleeved mode. The outer sleeve drill bit is provided with a limiting piece and a sawtooth blade is arranged at the top end of the outer sleeve drill bit, so that the bone tissue cutting range and depth can be locked and the bone tissue can be longitudinally cut; the built-in drill bit is a double-helix drill bit, two same fan-shaped blades are arranged at the top end of the built-in drill bit and can transversely cut and smash the longitudinally cut bone tissue, and a chip groove is formed by the double-helix structure of the built-in drill bit and can discharge the smashed bone tissue through the chip groove. The bone tissue drilling device is simple in structure, smashing and cleaning of bone tissue within a controllable range are achieved, and bone drilling efficiency and accuracy are greatly improved.