Liposome anti-fungus medication sprayer formulation

A technology of antifungal drugs and liposomes, applied in the field of medicine, can solve problems such as inability to eradicate patients, and achieve the effects of improving killing effect, improving drug efficacy, and increasing permeability

Inactive Publication Date: 2004-03-31
XIAN LIBANG PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current clinically used beriberi medicines cannot penetrate the cuticle of the skin and reach the lesion, so they cannot eradicate the disease.

Method used

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  • Liposome anti-fungus medication sprayer formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: Contain 0.1% mole miconazole nitrate in the drug liposome product.

[0048] name

[0049] Add the prescribed amount of lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil into 20ml of ethanol, heat to 45°C and stir to dissolve completely. Then slowly add the ethanol drug solution into 180ml of pure water stirred at a high speed (3000r / min) by a shearing machine, and continue to stir for 30min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase liposome drug solution was homogenized 7 times by a high-pressure homogenizer, and the pressure was 100 MPa. During the homogenization process, the temperature should not exceed 60°C to obtain a large single-chamber single-phase liposome drug solution with a particle size of 250nm ± 40nm. The final product after dilution is a uniform milky solution without precipitation and stratification. Store the product at 2°C-15°C and dark co...

Embodiment 2

[0050] Embodiment 2: Contain 15% mole miconazole nitrate in the drug liposome product.

[0051] name

molecular weight

Mole (%)

Feed amount (g)

Lecithin

760

74.0

18.7

cholesterol

386.66

7.5

1.3

miconazole nitrate

479.15

15.0

2.4

Oleic acid

282

3.0

0.3

Azone

281

0.1

0.01

Vitamin E

472

0.2

0.03

peppermint oil

0.2

0.3

[0052] Add 40ml of ethanol to the prescribed amount of lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil, heat and stir until completely dissolved. Slowly add the ethanol drug solution into 160ml of pure water stirred at high speed (3000r / min) by a shearing machine, and continue to stir for 35min under nitrogen protection to obtain the multiphase liposome drug solution. The multiphase lipo...

Embodiment 3

[0054] Embodiment 3: Contain 7% mole miconazole nitrate in the drug liposome product.

[0055] name

molecular weight

Mole (%)

Feed amount (g)

Lecithin

760

82.0

19.11

cholesterol

386.66

7.5

0.89

miconazole nitrate

479.15

7.0

0.10

Oleic acid

282

3.0

0.3

Azone

281

0.1

0.01

Vitamin E

472

0.2

0.03

peppermint oil

0.2

0.3

[0056] Add the prescribed amount of lecithin, cholesterol, oleic acid, miconazole nitrate, azone, vitamin E and peppermint oil into 30ml of ethanol, heat to 45°C and stir to dissolve completely. Slowly add the ethanol drug solution into 170ml of pure water stirred at a high speed (3000r / min) by a shearing machine, and continue stirring for 30min under nitrogen protection to obtain the multiphase liposome drug solution. The multi...

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Abstract

A spraying formulation of liposome and antifungal agents. It mainly comprises, antifungal drug chemically synthesized, liposome coating material, lecithin as the transdermal absorbing agent and skin protecting agent, cholesterol, oleinic acid ,Vit-E, alcohol and natural volatile oil. The spraying formulation prepared by the above-mentioned compounds could increase transdermal absorption of drugs,transmit drug to hypodermis.

Description

1. Technical field [0001] The invention belongs to the field of medicine, and relates to an antifungal medicine spray preparation, in particular to a liposome antifungal medicine spray preparation. 2. Background technology [0002] Athlete's foot, also known as Hong Kong's athlete's foot. Traditional Chinese medicine believes that the main symptoms of this disease are numbness, soreness and weakness of the shins. According to its symptoms, it is mainly divided into dry beriberi, wet beriberi and beriberi rushing to the heart. At the beginning, dizziness and fatigue, fatigue and anorexia, pinpricks or ants crawling on the feet, distributed in a sock-like distribution, followed by muscle soreness, muscle weakness, skin dullness, muscle relaxation, contracture, and foot edema. In severe cases, palpitations, shortness of breath, tachycardia, enlarged heart, swelling and pain in the lower limbs, when the swelling and pain extend from the knee to the thigh, confusion, wheezing a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K9/127A61K31/4164A61K31/4196A61K31/496A61P31/10
Inventor 陈涛惠民权王九成
Owner XIAN LIBANG PHARMA TECH
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