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Soluble and stable tilmicosin composition

A technology of tilmicosin and composition, which is applied in the field of tilmicosin preparations and achieves the effect of stable properties

Active Publication Date: 2009-08-05
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention solves the water solubility problem of tilmicosin, and the properties of tilmicosin are stable after being dissolved in water

Method used

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  • Soluble and stable tilmicosin composition
  • Soluble and stable tilmicosin composition
  • Soluble and stable tilmicosin composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment one: the preparation of soluble and stable tilmicosin soluble powder

[0022] The drug preparation is calculated on the basis of 500g per serving. The tilmicosin soluble powder composition is: 10 parts of tilmicosin, 5 parts of potassium dihydrogen phosphate, and 1.5 parts of tartaric acid. The preparation method is as follows: take 10 parts of tilmicosin, 5 parts of potassium dihydrogen phosphate, and 1.5 parts of tartaric acid according to weight; adopt the equal volume dilution method, use anhydrous glucose as a carrier, and make a mixture of raw materials and auxiliary materials after fully stirring evenly. A soluble and stable tilmicosin soluble powder.

Embodiment 2

[0023] Embodiment two: the preparation of soluble and stable compound tilmicosin soluble powder

[0024] The drug preparation is calculated on the basis of 1500g per serving. The composition of compound tilmicosin soluble powder is: 10 parts of tilmicosin, 10 parts of sulfamethazine sodium, 7 parts of potassium dihydrogen phosphate, 3 parts of tartaric acid, using anhydrous glucose as a carrier, stirring evenly into a compound tilmicosin soluble powder.

Embodiment 3

[0025] Embodiment three: the preparation of soluble and stable tilmicosin effervescent tablet

[0026] The drug preparation is calculated on the basis of 1kg per serving. The composition of tilmicosin effervescent tablet is: 10 parts of tilmicosin, 5 parts of sodium dihydrogen phosphate, 3 parts of malic acid, 4 parts of citric acid, 40002 parts of polyethylene glycol, 10 parts of sodium bicarbonate, sodium saccharin 0.1 part, 65 parts starch, 0.9 part essence. Carry out the preparation of effervescent tablet according to following process:

[0027] (1) 10 parts of tilmicosin were coated with 1 part of polyethylene glycol 4000 to obtain mixture A;

[0028] (2) Mix 5 parts of sodium dihydrogen phosphate, 3 parts of malic acid and 4 parts of citric acid evenly, and add 0.1 part of sodium saccharin to obtain mixture B;

[0029] (3) After coating 10 parts of sodium bicarbonate with 1 part of polyethylene glycol 4000, fully mix it with mixtures A, B, and 65 parts of starch, spra...

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Abstract

The invention relates to a soluble and stable Tilmicosin composition. The soluble preparation consists of the following components: Tilmicosin, a latent solvent, a pH value stabilizing agent and proper auxiliary materials. The Tilmicosin obtained by the invention can be quickly dissolved into water and the effective components cannot be degraded with the prolonging of the placing time of an aqueous solution. The preparation composition can be combined with other substances for use so as to strengthen the drug effect. The composition is mainly used for treating respiratory tract infection, mixed infection of mycoplasma and Escherichia coli, other various pneumonia and pulmonary infectious diseases of livestock and poultry caused by Pasteurella, the mycoplasma, and the like.

Description

technical field [0001] The invention belongs to veterinary preparations, in particular a soluble and stable tilmicosin preparation is invented, and the tilmicosin in the composition can be dissolved in water and is stable. The preparation is mainly used for preventing and treating bacterial diseases of livestock and poultry. Background technique [0002] Tilmicosin is a semi-synthetic macrolide antibiotic for livestock and poultry developed by Elanco, a subsidiary of Eli Lilly and Company in the 1980s. In veterinary clinical use, the overall antibacterial effect of tilmicosin on common pathogenic bacteria is stronger than that of tylosin, especially on some pathogenic bacteria such as Salmonella pullorum, Salmonella typhimurium, Klebsiella pneumoniae and other strains Stronger antibacterial effect than tylosin tartrate [1] . [0003] Tilmicosin is insoluble in water, so the "Guidelines for the Use of Veterinary Drugs" and "Quality Standards for Veterinary Drugs" record th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P31/04
Inventor 刘桂兰刘爱玲李旭东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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