Garlicin injection preparation

A technology of allicin and injections, which is applied in the field of medicine, can solve problems such as non-conformity, toxicity, and hemolysis, and achieve the effects of reducing irritation, high water solubility, and improving content and stability

Inactive Publication Date: 2003-11-19
王景成
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Allicin is almost colorless or light yellow clear liquid, almost insoluble in water, in order to make injections, Tween-80 must be added in the prescription, its concentration is as high as 1%, not only easy to produce hemolysis, but also has certain toxicity, does not meet the requirements Modern Pharmaceutical Preparation Requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1: Take 3.0 g of hydroxypropyl-β-cyclodextrin, add 8 ml of water, heat to dissolve, add 150 mg of allicin, stir, grind or ultrasonically dissolve to obtain allicin inclusion compound solution, add water for injection to 10ml, made into small needles of allicin.

Embodiment 2

[0010] Example 2: Take 1.8g of hydroxypropyl-β-cyclodextrin, add 50ml of water to dissolve, add 30mg of allicin, stir, grind or ultrasonically dissolve to obtain allicin inclusion complex solution, add 25g of glucose, dissolve , add water for injection to 500ml.

Embodiment 3

[0011] Example 3: Take 5.4g of hydroxypropyl-β-cyclodextrin, add 50ml of water to dissolve, add 60mg of allicin, stir, grind or ultrasonically dissolve to obtain allicin inclusion compound solution, add 4.5g of sodium chloride After dissolving, add water for injection to 500ml.

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PUM

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Abstract

A garlicin injection with greatly improved water solubility is prepared through adding hydroxypropyl beta-cyclodextrin in the water for injection, stirring, adding garlicin, stirring, grinding or ultrasonic pulverizing to obtain the garlicin inclusion compound solution, preparing injection or drying and preparing injection. Its advantages are high safety and stability and less irritation.

Description

Technical field: [0001] The invention relates to the technical field of medicine, more precisely, it relates to a preparation method of allicin injection. technical background: [0002] Garlic is not only a food, but also a traditional Chinese medicine with a wide range of uses. It is very rich in resources in my country and has a long history of medicinal use. [0003] Allicin (diallyl trisulfide, alltride), also known as allicin, chemically called diallyl trisulfide, is a compound isolated from garlic bulbs, with the highest content in garlic volatile oil, and is the main active ingredient of garlic. Element. [0004] my country began to study the pharmacology, clinical and chemical components of garlic in the 1950s. In recent years, with the deepening of research on the pharmacological activity of garlic, it was found that allicin has anti-bacterial, anti-fungal, anti-tumor, and insecticidal effects. It also has the effects of anti-virus, improving the body's immune func...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/10A61P9/06A61P9/10A61P9/12A61P31/04A61P31/10A61P31/12A61P35/00
Inventor 王景成王文彬
Owner 王景成
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