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Skin care cosmetic composition with whitening effect

A technology for skin care cosmetics, whitening effect, applied in the field of skin care cosmetic composition, to achieve remarkable effect of whitening effect

Inactive Publication Date: 2011-10-12
JIANGSU LONGLIQI BIOSCIENCE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But none of these patents mentioned how to solve the problem that resveratrol is insoluble in water and insoluble in oil.

Method used

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  • Skin care cosmetic composition with whitening effect
  • Skin care cosmetic composition with whitening effect
  • Skin care cosmetic composition with whitening effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Determination of free radical scavenging

[0024] DPPH· is a stable free radical in organic solvents, and its lone pair of electrons has a strong absorption near 517nm (shows deep purple). When the organic scavenger exists, the lone pair of electrons is paired, and the absorption disappears or weakens. By measuring the degree of absorption weakening, the activity of the free radical scavenger can be evaluated.

[0025] Take 2mL of the sample solution and 2mL of the DPPH solution with a concentration of 100μmoL / L and add it to the same stoppered test tube successively, shake well; let stand at room temperature for 30min, and measure the absorbance of the sample at a wavelength of 517nm.

[0026] Inhibition rate: K%=[1-(Ai-Aj) / Ac]×100%

[0027] Ai: absorbance of 2mL DPPH solution + 2mL resveratrol solution

[0028] Aj: Absorbance of 2mL resveratrol solution + 2mL solvent

[0029] Ac: absorbance of 2mL DPPH solution + 2mL solvent

[0030] The samples of each...

Embodiment 2

[0033] Embodiment 2: Determination of anti-ultraviolet performance

[0034] Table 2 resveratrol to the absorption rate of ultraviolet rays

[0035]

[0036] In the wavelength range of 280-400nm, scan every 10nm, determine the light transmittance of the resveratrol solution at each wavelength, and calculate the average absorbance in the wavelength range. The concentration of the sample solution was 10 μg / mL.

[0037] The experimental results are shown in Table 2.

Embodiment 3

[0038] Embodiment 3: Inhibition of tyrosinase activity test

[0039] The principle of the test is that under the action of tyrosinase, L-DOPA is oxidized to brown dopachrome, and the reaction will be inhibited in the presence of inhibitors.

[0040] Table 3 The inhibitory effect of resveratrol, arbutin and ethyl Vc on tyrosinase

[0041]

[0042]

[0043] The test reaction was carried out in a test tube. 0.1mL of DMSO solution containing different mass concentrations of resveratrol and 2.8mL of the substrate solution previously incubated in a constant temperature water bath at 30°C were first added to the test tube, mixed evenly, and then 0.1mL of 600 Unit / mL tyrosinase solution, mix well, place in a 30°C water bath for 10 minutes, and immediately use a spectrophotometer to measure the absorption peak of dopachrome at 475nm. According to the measured absorbance (OD value), the inhibition rate (%) of the sample to the tyrosinase activity was calculated.

[0044] Inhibit...

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PUM

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Abstract

The invention provides a skin care cosmetic composition with a whitening effect. The skin care cosmetic composition comprises: (a) at least more than 0.5% of whitening agent which is resveratrol nanoemulsion; and (b) a carrier of the resveratrol nanoemulsion, which can be accepted by skin. According to the skin care cosmetic composition provided by the invention, the resveratrol is used as a main effect additive ingredient, and specifically, and the resveratrol nanoemulsion is used as a main effect additive; since the resveratrol nanoemulsion has excellent water solubility and oil solubility, excellent stability and high bioavailability, the use difficulty that unwrapped resveratrol is water-insoluble and oil-insoluble is avoided effectively, so that the resveratrol can be applied to various types of cosmetics conveniently. The resveratrol nanoemulsion is applied to cosmetics and capable of removing free radicals, resisting oxidation and inhibiting activity of tyrosinase, thus achieving the effect of whitening.

Description

technical field [0001] The invention relates to a skin care cosmetic composition, in particular to a skin care cosmetic composition with good whitening effect. Background technique [0002] As the saying goes: white skin covers all ugliness, and fair skin is the most attractive. For Asian women with naturally yellow skin, having fair skin has always been an important issue in beauty. [0003] The color of the skin mainly depends on the amount of melanin contained in the skin. Melanin is produced by melanocytes in the epidermis, and its synthesis is affected by a variety of enzymes in the cell, among which tyrosinase is the main rate-limiting enzyme, and the activity of this enzyme determines the amount of melanin formed. In addition, the synthesis of melanin is also affected by factors such as ultraviolet rays and free radicals. [0004] Resveratrol (RES) widely exists in natural plants and fruits such as grapes, pine trees, knotweed, cassia and peanuts. The molecular str...

Claims

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Application Information

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IPC IPC(8): A61K8/33A61K8/92A61K8/86A61Q19/02
Inventor 史先敏徐之伟严泽民刘冬周华峰段明星
Owner JIANGSU LONGLIQI BIOSCIENCE CO LTD
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