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Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof

A nano-composition, a technology of whitening ingredients, applied in the directions of medical preparations containing active ingredients, organic active ingredients, preparations for skin care, etc., can solve the problems such as the difficulty of obvious whitening effect, the inability to enter the skin, and the difficulty of percutaneous absorption. , to achieve the effect of enhancing bioavailability, increasing moisture content and good stability

Inactive Publication Date: 2017-04-26
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it has an unsaturated lactone ring, it is easy to oxidize and decompose to lose its efficacy, and it is difficult to absorb through the skin and cannot enter the skin, so it is difficult to clearly reflect the whitening effect.

Method used

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  • Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof
  • Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof
  • Nanometer composition containing skin-moistening and whitening components, and preparation method and application thereof

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preparation example Construction

[0037] The present invention provides a preparation method for the above-mentioned nano composition containing moisturizing and whitening ingredients, comprising the following steps:

[0038] (1) mixing the liquid lipid, the resorcinol derivative, the vitamin and its derivative, the surfactant, the co-emulsifier and the polyol to obtain a mixed oil phase;

[0039] (2) Under the condition of stirring, add water dropwise into the mixed oil phase and mix to obtain the nano composition.

[0040] The present invention uniformly mixes surface liquid lipids, resorcinol derivatives, vitamins and derivatives thereof, surfactants, co-emulsifiers, polyhydric alcohols, etc. to obtain a mixed oil phase. The mixing method is stirring and mixing, and the stirring speed is preferably 10-1000 rpm, more preferably 30-600 rpm. In the present invention, in order to shorten the mixing time and increase the mixing effect, heating can be used. In the present invention, there is no specific limitat...

Embodiment 1

[0045] Weigh respectively 0.1% isopropyl myristate, 0.01% hexylresorcinol, 0.01% vitamin E, 0.1% sorbitol laurate, 0.1% ethoxydiethylene glycol Alcohol oleate and 0.1% glycerin were uniformly mixed at a temperature of 10° C. and a stirring rate of 1000 rpm to obtain a mixed oil phase 1 . Add 99.58% water into the mixed oil phase 1 at a temperature of 10°C and a stirring rate of 1000 rpm until the mixed solution is clear and translucent to obtain the nano composition 1 containing moisturizing and whitening ingredients.

Embodiment 2

[0047] Weigh respectively 7% isopropyl myristate, 3% caprylic capric triglyceride, 2% dimethoxycresyl-4-propyl resorcinol, 4% scurvy Dipalmitate, 5% Polyoxyethylene Hydrogenated Castor Oil, 10% Ethoxylated Diethylene Glycol Oleate, 5% Polyglyceryl-6 Isostearate, 10% Propylene Glycol, 5% Polyethylene glycol was uniformly mixed at a temperature of 70° C. and a stirring rate of 10 rpm to obtain a mixed oil phase 2 . 47% of water was added to the mixed oil phase 2 at a temperature of 70°C and a stirring rate of 10 rpm until the mixed solution was clear and translucent, and the nano composition 2 containing moisturizing and whitening ingredients was obtained.

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Abstract

The invention provides a nanometer composition containing skin-moistening and whitening components. The nanometer composition comprises, by mass, 0.1 to 10% of liquid lipid, 0.01 to 2% of a resorcinol derivative, 0.01 to 10% of vitamins and derivatives thereof, 0.1 to 15% of a surfactant, 0.1 to 10% of a co-emulsifier and 0.1 to 15% of polyol, with the balance being water. The nanometer composition containing skin-moistening and whitening components in the invention has good biocompatibility, is free of irritation to the skin, can rapidly increase the surface moisture content of the skin and exerts obvious moisture-retaining and skin-moistening effect; after long-term usage, the nanometer composition can improve the whiteness of the skin and exerts obvious whitening effect; and the preparation method for the nanometer composition is simple, fast and suitable for industrial production.

Description

technical field [0001] The invention relates to a nano composition, in particular to a nano composition containing moisturizing and whitening ingredients. Background technique [0002] The surface of the skin is covered with a film composed of skin oil and glial cells, which has the effect of moisturizing the skin. When the surface layer of the skin is sufficiently hydrated, the skin will not only be soft and smooth without fine lines, but also full of elasticity to the touch, which is the basis for follow-up maintenance. However, with age and unhealthy lifestyles, the water in the stratum corneum will gradually lose. When the content is less than 10%, the skin will appear dry, fine lines, tight, rough and desquamated. The formulations of moisturizing skin care products on the market include creams, lotions, essences, toners, masks, etc. However, there are defects such as single function, inconspicuous moisturizing effect, and unsustainable effect. [0003] Whitening and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/37A61K8/86A61K8/34A61K8/67A61Q19/02A61Q19/00A61K31/375A61P17/00A61P17/16A61K31/355A61K31/05
CPCA61K8/375A61K8/345A61K8/347A61K8/37A61K8/676A61K8/678A61K8/86A61K8/922A61K31/05A61K31/355A61K31/375A61K2800/413A61Q19/00A61Q19/02A61K2300/00
Inventor 许琦吕萌刘卫闻庆郭凤凤石丛姣陈家铃杨达峰
Owner WUHAN BEST CARRIER NANO TECH
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