Anticancer Chinese traditional extracts and preparation process and application thereof

Abstract

The invention discloses a prepared traditional Chinese medicinal preparation having anticancer reactivity, which is an extraction containing saponin prepared from Marsdenia tenacissima, a traditional Chinese medicinal Asclepiadaceae plant through refining. The invention also discloses the process for preparing the traditional Chinese medicinal preparation having anticancer reactivity and its use.

Description

Technical field [0001] The present invention relates to a traditional Chinese medicine extract, more specifically, the present invention relates to an effective part extracted from the traditional Chinese medicine Wu Guteng. The invention also relates to a preparation method and application of the traditional Chinese medicine extract. Background technique [0002] With the advancement of medicine, general infectious diseases are gradually controlled, and malignant tumors, cancer, have become one of the main diseases that are common and seriously threaten human life and quality of life. Since 1996, there have been more than 10 million newly diagnosed cancer patients worldwide each year, and more than 7 million deaths. By the end of 1999, the total number of cancer patients worldwide had exceeded 40 million. The incidence of tumors in my country is also alarming, and it has become the second leading cause of death in our country. According to statistics from the Ministry of Health,...

AI Technical Summary

Problems solved by technology

[0003] There are many anti-tumor chemical drugs, such as cyclophosphamide, 5-fluorouracil, cytarabine, bleomycin, vinblastine, harringtonine, cisplatin, carboplatin, etc., but they not only It only kills local cancer cells, but also kills white blood cells in the bone marrow, causing leukopenia, which makes patients susceptible to infectious diseases. Chemotherapy drugs can also affect the ability of bone marrow hematopoietic cells and platelet production, causing patients to encounter very slight damage , can also cause bleeding or internal bleeding. In addition, secondary tumors caused by chemotherapy may appear many years later; existing chemotherapy drugs still have the following side effects, such as: nausea, vomiting, anorexia, hair loss, stomatitis, allergies Sexual rash, liver function damage and decreased body resistance, prone to secondary infections, etc. Some chemotherapy drugs can also damage the cells of the heart, kidney, bladder, lung and nervous system, etc., all of which will increase the pain of the patient. Affect the quality of life of patients, so its application has great limitations

[0004] Existing traditional Chinese medicines are divided into two categories when they are used for tumor treatment. One category is therapeutic drugs, such as some compound prescriptions, but there are disadvantages such as unclear active ingredients, unclear mechanism, and low potency, and some compound prescriptions even contain huge toxic ingredients. , such as arsenic, angelica, mylabris, improper application, easy to produce serious side effects, and even life-threatening; and traditional Chinese medicine anti-tumor polysaccharides such as lentinan, ginseng polysaccharides, etc. Although the toxicity is low, but because they are macromolecular foreign substances , entering the blood is prone to hypersensitivity reactions, resulting in serious consequences, ginsenoside Rg3 and other anti-angiogenic preparations can also inhibit the neovascularization of normal blood vessels

Another type of tumor treatment drug is tumor adjuvant drug, which is used to reduce the side effects of radiotherapy and chemotherapy, but it does not have the effect of directly treating tumors.

So far, there has been no report that the saponin-containing extract of the romoaceae plant Agnaceae has anticancer effects