Fucoxanthin-containing composition and method for producing same

A technology of fucoxanthin and composition, which is applied in the direction of medical preparations containing active ingredients, drug combinations, non-active ingredients of polymer compounds, etc., and can solve problems such as disappearance, instability of carotenoids, and decomposition of carotenoids , to achieve the effect of high storage stability

Inactive Publication Date: 2015-09-23
KYOWA HAKKO BIO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, decomposition or disappearance of carotenoids sometimes occurs by high-temperature treatment used to form an amorphous state
In addition, it is known that since carotenoids are unstable as substances, they decompose or disappear over time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Manufacture and Evaluation of Compositions Containing Fucoxanthin (1)

[0086] As an emulsifier for emulsifying fucoxanthin, enzymatic lecithin (SLP-White Lyso, manufactured by Tsuji Oil Co., Ltd.), polyglycerol fatty acid ester (decaglyceryl monolaurate), sucrose fatty acid ester ( Ryoto Sugar Ester S-1670, manufactured by Mitsubishi Chemical Foods Co., Ltd.), and their combinations were evaluated. The formulations are shown in Table 1 and evaluated as follows.

[0087] An aqueous solution obtained by adding a total of 5.0 g of emulsifiers, 30.0 g of γ-cyclodextrin (cyclodextrin γ-100, Shimizu Port Seiko) and 54.0 g of sucrose to 150 g of distilled water at the ratio shown in Table 1 and dissolving them Add 10.0 g of fucoxanthin (oil containing 1.0% fucoxanthin, manufactured by BGG) and 1.0 g of tocopherol (tocopherol AT-160, manufactured by J-oil mills) and mix at 50-60°C The obtained oil-soluble components were mixed using an ace homogenizer (manufactured by Nippon...

Embodiment 2

[0100] Manufacture and Evaluation of Compositions Containing Fucoxanthin (2)

[0101] To 150 g of distilled water, 2.5 g of decaglyceryl monolaurate, 7.5 g of sucrose fatty acid ester, and 30.0 g of the excipients shown in Table 3 in the ratio shown in Table 4, and 49.0 g of sucrose were added and dissolved. To the obtained aqueous solution, an oil-soluble component obtained by mixing 10.0 g of fucoxanthin (1.0% oil, manufactured by BGG Corporation) and 1.0 g of tocopherol (tocopherol AT-160, J-oil mills) at 50 to 60°C was added , so as to obtain a mixture of water phase and oil phase. After that, it was mixed using a stirrer (TK homomixer MARII, special mechanism, 7000 rpm, 15 minutes), and emulsified using a high-pressure homogenizer (APV2000, SMT, 700 bar, 3 times) to obtain an emulsion. The obtained emulsion was spray-dried by a small spray dryer (B-290, BUCHI) to obtain a powder. The obtained powder was stored in an incubator at 60° C. for 0.5 month, and the content of ...

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Abstract

A fucoxanthin-containing composition containing: (A) fucoxanthin; (B) one or more emulsifiers selected from the group consisting of a glycerin fatty-acid ester, a polyglycerin fatty-acid ester, a sucrose fatty-acid ester, and lecithin; and (C) one or more excipients selected from the group consisting of cyclodextrin and a gum. A method for producing a fucoxanthin-containing composition, having: a step for mixing (A) fucoxanthin, (B) one or more emulsifiers selected from the group consisting of a glycerin fatty-acid ester, a polyglycerin fatty-acid ester, a sucrose fatty-acid ester, and lecithin, and (C) one or more excipients selected from the group consisting of cyclodextrin and a gum; and a step for drying the obtained composition.

Description

technical field [0001] The present invention relates to a method for producing a fucoxanthin-containing composition. In addition, in detail, it relates to a fucoxanthin-containing composition that can be incorporated into health foods and the like, which is stable even when stored for a long period of time, although it contains a high content of fucoxanthin. Background technique [0002] Fucoxanthin is one of carotenoids contained in trace amounts in seaweed such as kelp, wakame, mozuku, and hijiki. In recent years, as studies on fucoxanthin have progressed, various properties such as anti-obesity, anti-diabetes, anti-oxidation, and anti-inflammatory effects have been reported, and it has attracted attention as a functional raw material derived from seaweed. Especially in the anti-obesity effect, it is based on the molecular mechanism of inducing a special protein (UCP1) that dissipates fat as heat in white adipocytes, and no ingredient exhibiting such an effect has been co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/336A61K9/107A61K47/14A61K47/24A61K47/26A61K47/34A61K47/36A61K47/40A61P3/04A61P3/10A61P29/00A61P39/06A61P43/00A23L1/30
CPCA23V2002/00A23L1/293A23L1/3002A23L1/302A23L1/308A61K47/40A61K9/107A61K31/336A61K47/36A61K47/22A23L33/105A23L33/15A23L33/21A23L33/30A61P3/04A61P3/10A61P29/00A61P39/06A61P43/00A23V2200/30A23V2200/328A23V2200/332A23V2250/202A23V2250/502A23V2250/5028A23V2250/5112A23V2250/712
Inventor 根桥直大室町绫子中野裕一郎
Owner KYOWA HAKKO BIO CO LTD
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