Traditional Chinese medicine composition for dogs and application

Abstract

The composition is prepared from the following raw materials in parts by weight: 20 to 40 parts of scorched hawthorn fruit, 5 to 15 parts of fried medicated leaven, 5 to 15 parts of rhizoma pinelliae, 3 to 7 parts of pericarpium citri reticulatae, 3 to 7 parts of fried semen raphani, 3 to 7 parts of endothelium corneum gigeriae galli, 5 to 15 parts of poria cocos, 3 to 7 parts of fructus forsythiae, 1 to 3 parts of fried malt, 0.5 to 1.5 parts of fructus foeniculi and 1 to 3 parts of chicken liver powder. The compound can be used for preparing drugs for treating canine digestive system diseases. According to the traditional Chinese medicine composition for dogs, the dietary structure and digestive physiological characteristics of dogs are optimized, rhizoma pinellinae praeparata is used, the use amount of malt is reduced, and the palatability of the prepared medicine is remarkably improved by matching with endothelium corneum gigeriae galli, fennel and chicken liver powder; meanwhile, compared with a traditional formula, the composition has the advantages that the apparent digestibility of the dogs is remarkably improved, the liver and kidney functions of the dogs are not remarkably influenced, and the composition is safe to take.

Description

Technical Field

[0001] The present invention relates to traditional Chinese veterinary medicine, and particularly to a traditional Chinese medicine composition for dogs and its application. Background Art

[0002] With the increase in the number of pet dogs raised, digestive system diseases caused by unreasonable diet structures and eating habits have become important health problems troubling pet owners. The digestive system of dogs is characterized by short gastrointestinal tracts and concentrated digestion times. When high-fat and high-protein foods are ingested or the eating speed is too fast, it is extremely easy to cause the phenomenon of food stagnation in the gastrointestinal tract. In old dogs, due to the slowdown of gastrointestinal peristalsis and the decrease in the secretion of digestive enzymes, the digestive and absorption functions further decline, and chronic indigestion and recurrent gastrointestinal dysfunction are more common. These diseases not only cause malnutrition and decreased immunity in pets, but if not improved for a long time, they may also lead to secondary diseases such as metabolic syndrome and pancreatitis, forming a double pressure of health hazards and economic burdens.

[0003] In the traditional Chinese medicine system, Baohe Pills, as a classic prescription for eliminating indigestion and stagnation, its formula fully reflects the therapeutic principle of "invigorating the spleen to promote digestion, regulating qi and harmonizing the stomach". This prescription uses Hawthorn Fruit as the monarch drug, taking advantage of its characteristic of being rich in organic acids to decompose meat stagnation; compatibility with Germinated Barley and Six-Flavored Medicinal Leaven as ministerial drugs, the former contains amylase to promote the digestion of carbohydrates, and the latter produces various digestive enzymes through the fermentation process; assisted with Tangerine Peel to regulate qi and relieve distension, Poria to strengthen the spleen and promote diuresis, and Forsythia Fruit to clear heat and dissipate nodules, forming a compatibility characteristic of both eliminating and tonifying. Compared with chemical digestive drugs, Baohe Pills can not only directly enhance the activity of digestive enzymes, but also improve the function of the spleen and stomach in transportation and transformation, having the advantage of overall regulation.

[0004] However, there may still be significant limitations in the clinical application of Baohe Pills in pets: on the one hand, existing research is mostly based on the derivation of traditional Chinese medicine theory, lacking optimization for the digestive physiological characteristics of dogs, and there is a certain controversy about whether it is applicable to dogs; on the other hand, there are still deficiencies in the palatability and convenience of taking of existing traditional Chinese veterinary medicine preparations for pets, and forced feeding is likely to cause stress reactions. Therefore, it is necessary to conduct targeted research on pet specialization on the basis of maintaining the advantages of the traditional formula. Summary of the Invention

[0005] Object of the Invention: The object of the present invention is to provide a traditional Chinese medicine composition for dogs and its application in the preparation of drugs for treating canine digestive system diseases.

[0006] Technical Solution: The traditional Chinese medicine composition for dogs described in the present invention contains the following raw materials in parts by weight: 20 - 40 parts of Stir-Fried Hawthorn Fruit, 5 - 15 parts of Stir-Fried Six-Flavored Medicinal Leaven, 5 - 15 parts of Pinellia Tuber, 3 - 7 parts of Tangerine Peel, 3 - 7 parts of Stir-Fried Radish Seed, 3 - 7 parts of Endothelium Corneum Gigeriae Galli, 5 - 15 parts of Poria, 3 - 7 parts of Forsythia Fruit, 1 - 3 parts of Stir-Fried Germinated Barley, 0.5 - 1.5 parts of Fructus Foeniculi, and 1 - 3 parts of chicken liver powder.

[0007] Preferably, the raw materials contained in the composition are in a weight ratio of 28-32 parts of stir-fried Hawthorn Fruit, 8-12 parts of stir-fried Six-Flavored Divine Comedy, 8-12 parts of Pinellia Tuber, 8-12 parts of Dried Tangerine Peel, 4-6 parts of stir-fried Radish Seed, 4-6 parts of Endothelium Corneum Gigeriae Galli, 8-12 parts of Poria, 4-6 parts of Forsythia Fruit, 1.8-2.2 parts of stir-fried Fructus Hordei Germinatus, 0.9-1.1 parts of Fennel Fruit, and 1.8-2.2 parts of chicken liver powder.

[0008] Preferably, the Pinellia Tuber is Prepared Pinellia Tuber.

[0009] Application of the traditional Chinese medicine composition for dogs in the preparation of drugs for treating canine digestive system diseases.

[0010] Preferably, the canine digestive system disease is food retention.

[0011] Preferably, the dosage form of the drug is decoction, powder or pill.

[0012] Preferably, the dosage form of the drug is honey pill.

[0013] Preferably, the drug contains the aforementioned traditional Chinese medicine composition for dogs and refined honey with a water content of 12-18% and a mass 1.25-1.55 times that of the traditional Chinese medicine composition for dogs.

[0014] Preferably, the traditional Chinese medicine composition for dogs in the drug is a powder obtained by separately pulverizing each raw material, sieving through a sieve, and mixing evenly.

[0015] Preferably, the honey pill weighs 3 g or 6 g.

[0016] Beneficial effects: Compared with the prior art, the present invention has the following remarkable advantages:

[0017] 1. The traditional Chinese medicine composition for dogs is optimized according to the dietary structure and digestive physiological characteristics of dogs. Prepared Pinellia Tuber is used, the dosage of Fructus Hordei Germinatus is reduced, and it is combined with Endothelium Corneum Gigeriae Galli, Fennel Fruit, and chicken liver powder, significantly improving the palatability of the prepared drug;

[0018] 2. Compared with the traditional formula, the traditional Chinese medicine composition for dogs significantly improves the apparent digestibility of dogs, and has no significant impact on the liver and kidney functions of dogs, and is safe to take. Description of the Drawings

[0019] Figure 1 It is a statistical result chart for the determination of apparent digestibility. Detailed Embodiments

[0020] The technical solutions of the present invention will be further described below.

[0021] Example 1 Preparation of honey pills for dogs

[0022] 1. Weigh 300 g of stir-fried hawthorn fruit, 100 g of stir-fried six-fermented medicinals, 100 g of prepared pinellia tuber, 50 g of dried tangerine peel, 50 g of stir-fried radish seed, 50 g of chicken's gizzard-membrane, 100 g of poria cocos, 50 g of forsythia fruit, 20 g of stir-fried malt, 10 g of fennel, and 20 g of chicken liver powder. Crush them separately, and after passing through an 80-mesh sieve, mix them evenly.

[0023] 2. Take honey and heat it to 116 - 118 °C for refining to obtain medium-density honey with a water content of 15%.

[0024] 3. Add 1062.5 g of the medium-density honey obtained in step 2 to the medicinal powder obtained in step 1 to form a mass, and roll it into strips to prepare honey pills for dogs with a pill weight of 3 g or 6 g.

[0025] Preparation of Baohe Pills in Comparative Example 1

[0026] 1. Weigh 300 g of stir-fried hawthorn fruit, 100 g of stir-fried six-fermented medicinals, 100 g of processed pinellia tuber, 50 g of dried tangerine peel, 50 g of stir-fried radish seed, 100 g of poria cocos, 50 g of forsythia fruit, and 50 g of stir-fried malt. Crush them separately, and after passing through an 80-mesh sieve, mix them evenly.

[0027] 2. Take honey and heat it to 116 - 118 °C for refining to obtain medium-density honey with a water content of 15%.

[0028] 3. Add 1062.5 g of the medium-density honey obtained in step 2 to the medicinal powder obtained in step 1 to form a mass, and roll it into strips to prepare Baohe Pills with a pill weight of 3 g or 6 g.

[0029] Experimental Example 1 Palatability Test

[0030] Randomly select 30 healthy dogs, including 15 male dogs and 15 female dogs, with a body weight range of 2.5 - 40 kg. The specific situation of each dog is shown in Table 1 below.

[0031] Table 1 Situation of Dogs in Palatability Test

[0032]

[0033] The drug administration method of the present invention adopts a double-blind crossover design. The test personnel guide the dog owners to operate according to the standard process: use the dog honey pills prepared in Example 1 as the test group and the Baohe Pills prepared in Comparative Example 1 as the control group. After uniformly coding the two kinds of pills, randomly provide them. The dog owners hold the samples 20 cm in front of the dog's mouth and let them stand still for 2 minutes. Verbal encouragement is allowed, but physical contact is prohibited. If the dog does not eat independently, the dog owner gently holds the dog's lower jaw and puts it into the mouth, and keep the mouth closed for 30 s.

[0034] The administration sequence of the experimental group and the control group adopted an alternating design: in the first time, the dog honey pill of Example 1 was administered first, and then the Baohe Pills of Comparative Example 1 were administered; in the second time, the Baohe Pills of Comparative Example 1 were administered first, and then the dog honey pill of Example 1 was administered. The administration sequence alternated, and the interval between the two administrations was 4 hours. Other interference sources were isolated in the environment, and the administrator was blind throughout the process to avoid inducing behavior. The appearance, weight, and touch of the dosage forms were made consistent to eliminate recognition bias.

[0035] If the dog took the medicine actively or after being fed by the experimenter, it was determined that the administration was successful. If the dog vomited, refused to take the medicine, or partially ingested the medicine after taking it, it was determined that the administration was failed. The total acceptance rate was calculated according to the following formula:

[0036]

[0037] Result determination: If the total acceptance rate of the dog was at least 80% or more, it was determined that the palatability was good. One-way ANOVA was performed using Prism 8.0 statistical software, and the significance level was set at P < 0.05. As shown in Table 2, the acceptance rates of the experimental dogs for the dog honey pill of Example 1 were all above 80%, which was significantly higher than that of the Baohe Pills.

[0038] Table 2 Total acceptance rate of dogs for each administration

[0039]

[0040] Note: For each administration, n = 30, and the total number of administrations = n × 4 = 120

[0041] Test Example 2 Digestibility Test

[0042] The same 30 healthy dogs as in Test Example 1, including 15 male dogs and 15 female dogs, with a body weight range of 2.5 - 40 kg. They were randomly divided into the dog honey pill treatment group prepared in Example 1 (this product), the Baohe Pills control group prepared in Comparative Example 1 (Baohe Pills), and the blank control group (blank), with 5 male dogs and 5 female dogs in each group, a total of 10 dogs. They were continuously fed for 7 days, and the medicine was administered after meals, twice a day. Small dogs (body weight less than 10 kg) ate 1 - 2 pills of 3 g pills each time, medium dogs (10 kg < body weight < 30 kg) ate 1 - 2 pills of 6 g pills each time, and large dogs (body weight greater than 30 kg) ate 2 - 4 pills of 6 g pills each time. If the dog refused to eat, it was force-fed artificially.

[0043] Fresh feces were collected on the 4th - 7th day of the experiment and stored in a -20 refrigerator for later use. Pretreatment of fecal samples: Take the naturally thawed fecal samples, dry them at 65°C for 24 h, pulverize them, and then use the indicator method to measure the apparent digestibility. The calculation formula is as follows:

[0044]

[0045] The results are as Figure 1As shown, the apparent digestibility of organic matter, crude protein, and crude fat in the experimental group of dog food with honey pills is better than that in the Baohe Pills control group.

[0046] Analysis of Serum Biochemical Indexes in Test Example 3

[0047] One week after administration in Test Example 2, serum was collected to analyze the indexes of alkaline phosphatase (ALP), glutamate aminotransferase (ALT), blood urea nitrogen (BUN), creatinine (CRE), total protein (TPRO), albumin (ALB), and blood glucose (GLU).

[0048] The blood biochemical indexes of dogs are shown in Table 3. The dog honey pills prepared in Example 1 have no significant effect on the liver and kidney functions, protein metabolism, and sugar metabolism of dogs, and are safe to take.

[0049] Table 3 Detection Results of Blood Biochemical Indexes of Dogs

[0050]

Claims

1. A traditional Chinese medicine composition for dogs, characterized in that, In the composition, the raw materials are in the following weight ratios: 20 - 40 parts of stir-fried Hawthorn Fruit, 5 - 15 parts of stir-fried Six-Flavored Medicinal Leaven, 5 - 15 parts of Pinellia Tuber, 3 - 7 parts of Dried Tangerine Peel, 3 - 7 parts of stir-fried Radish Seed, 3 - 7 parts of Endothelium Corneum Gigeriae Galli, 5 - 15 parts of Poria, 3 - 7 parts of Forsythia Fruit, 1 - 3 parts of stir-fried Germinated Barley, 0.5 - 1.5 parts of Fennel Fruit, and 1 - 3 parts of chicken liver powder.

2. The canine traditional Chinese medicine composition according to claim 1, wherein In the composition, the raw materials are in the following weight ratios: 28 - 32 parts of stir-fried Hawthorn Fruit, 8 - 12 parts of stir-fried Six-Flavored Medicinal Leaven, 8 - 12 parts of Pinellia Tuber, 8 - 12 parts of Dried Tangerine Peel, 4 - 6 parts of stir-fried Radish Seed, 4 - 6 parts of Endothelium Corneum Gigeriae Galli, 8 - 12 parts of Poria, 4 - 6 parts of Forsythia Fruit, 1.8 - 2.2 parts of stir-fried Germinated Barley, 0.9 - 1.1 parts of Fennel Fruit, and 1.8 - 2.2 parts of chicken liver powder.

3. The canine traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The Pinellia Tuber is Prepared Pinellia Tuber.

4. Use of the traditional Chinese medicine composition for dogs according to claim 1 or 2 in the preparation of a medicament for treating digestive system diseases in dogs.

5. The application according to claim 4, characterized in that, The digestive system diseases in dogs are food retention and stagnation.

6. The application according to claim 4, wherein The dosage form of the medicament is decoction, powder or pill.

7. The application according to claim 6, wherein The dosage form of the medicament is honey pill.

8. The application according to claim 7, characterized in that, The medicament contains the traditional Chinese medicine composition for dogs according to claim 1 or 2, and refined honey with a water content of 12 - 18% and a mass 1.25 - 1.55 times that of the traditional Chinese medicine composition for dogs.

9. The application according to claim 8, wherein In the medicament, the traditional Chinese medicine composition for dogs is a powder obtained by separately pulverizing each raw material, sieving through a sieve, and mixing evenly.

10. The application according to claim 7, wherein The weight of each honey pill is 3 g or 6 g.

Images