Cryoablation probe shell covered by expandable hydrogel and preparation method thereof

A hydrogel and probe technology, used in cooling surgical instruments, heating surgical instruments, coatings, etc., can solve problems such as inability to effectively prevent needle tract metastasis, incomplete ablation of the target area, and tumor cell shedding, etc. Wound healing, freezing injury prevention, excellent biological activity

Active Publication Date: 2011-04-06
ACCUTARGET MEDIPHARMA (SHANGHAI) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the immature ablation treatment technology and the influence of various factors such as human error, it may lead to incomplete ablation of the target area, and a small amount of remaining tumor cells fall off from the primary tum

Method used

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  • Cryoablation probe shell covered by expandable hydrogel and preparation method thereof
  • Cryoablation probe shell covered by expandable hydrogel and preparation method thereof
  • Cryoablation probe shell covered by expandable hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Thermothermal ablation probe housing covered with expandable sodium alginate hydrogel coating

[0038] (1) Preparation of sodium alginate hydrogel solution

[0039] Dissolve 10 grams of sodium alginate with a viscosity range of 200mpa.s in water to form a 3% aqueous solution;

[0040] (2) Pore formation of sodium alginate hydrogel solution

[0041]Add 20 grams of plant peanut oil as a pore-forming agent and 5 grams of Tween80 as an emulsifier to the sodium alginate hydrogel solution obtained in step (1), stir vigorously until the emulsification is uniform, and place it at a temperature of 37°C and a rotation speed of 120 rpm The constant temperature shaker was used for 24 hours to completely dissolve the sodium alginate in water. At the same time, in order to attract cell growth, the surface of the hydrogel coating must be positively charged, and the pH value of the sodium alginate solution was adjusted to 3.8 with 0.1M hydrochloric acid;

[0042] (3) shell coating, c...

Embodiment 2

[0049] Hot and cold ablation probe housing covered with expandable chitosan hydrogel coating

[0050] (1) Preparation of chitosan hydrogel solution

[0051] Dissolve 0.3 g of chitosan with a deacetylation degree greater than 90% of 100 mesh in 9.7 g of 1% acetic acid aqueous solution;

[0052] (2) Chitosan hydrogel pore making

[0053] Add 2 grams of polyethylene glycol, a pore-forming agent with a molecular weight of 5000, to the solution obtained in step (1). After the polyethylene glycol is evenly dispersed in the chitosan solution, place the temperature at 37°C and rotate at 120 rpm. min constant temperature shaker for 1 hour to completely dissolve chitosan;

[0054] (3) shell coating, curing

[0055] Add 0.2 ml of cross-linking agent, namely 20% formaldehyde solution, to the chitosan hydrogel solution obtained in step (2) after pore making;

[0056] The concentric hollow stainless steel tube is a mould, and the chitosan hydrogel solution adding a crosslinking agent is...

Embodiment 3

[0062] Hot and cold ablation probe housing covered with expandable pectin hydrogel coating

[0063] (1) Preparation of pectin hydrogel solution

[0064] Dissolving 5 grams of pectin with an esterification degree of less than 10% and a galacturonic acid greater than 80% in water to form a 5% aqueous solution;

[0065] (2) Pore making of pectin hydrogel solution

[0066] Add 10 grams of pore-forming agent vegetable peanut oil and 3 grams of emulsifier Tween80 to the pectin hydrogel solution obtained in step (1), stir vigorously until the emulsification is uniform, and place it on a constant temperature shaker at 95°C with a speed of 120 rpm 0.5 hours, the pectin is completely dissolved in water;

[0067] (3) shell coating, curing

[0068] Apply the hole-made pectin gel solution obtained in step (2) evenly on the non-working section of the hot and cold ablation probe shell, with a thickness of about 15mm, and cover the coating with a concentric hollow stainless steel tube as ...

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Abstract

The invention discloses a cryoablation probe shell covered by expandable hydrogel and a preparation method thereof. The cryoablation probe shell is characterized by comprising a cryoablation probe shell made of metal and a hydrogel coating covering the probe shell, wherein the cryoablation probe shell comprises integrated working section and non-working section; the hydrogel coating is uniformly coated on the non-working section of the cryoablation probe shell, and the thickness of the hydrogel coating is 50 mu m to 500 mu m. The hydrogel coating comprises degradable porous hydrophilic hydrogel and absorbs water to rapidly expand to form a hydrogel isolating membrane to isolate the cryoablation probe from normal tissue, and plays the function of protecting the normal tissue of a non-target area.

Description

technical field [0001] The invention relates to a cryo- or thermal ablation therapy tumor probe shell, in particular to a cold-heat ablation probe shell covered with expandable hydrogel that can protect normal tissues in non-target areas and a preparation method thereof, which belongs to medical equipment technology field. Background technique [0002] Under the premise of not affecting the treatment effect, surgical operations are gradually developing towards reducing damage, retaining functions as much as possible and maintaining a perfect appearance. Traditional surgical resection is no longer the only option for tumor treatment. Minimally invasive ablation therapy has become a new force in tumor treatment, and has been widely used in the treatment of malignant tumors in liver, lung, prostate and other parts. The basis of non-surgical ablation therapy for primary tumors is to kill tumor cells by transforming cold and heat energy. With the development of cell biology, m...

Claims

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Application Information

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IPC IPC(8): A61B18/02A61B18/04A61L31/10
Inventor 叶萍常兆华
Owner ACCUTARGET MEDIPHARMA (SHANGHAI) CO LTD
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