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Protamine compounded preparation, preparation method and application thereof

A protamine and preparation technology, applied to the application of the protamine compound preparation, the field of preparing the protamine compound preparation, can solve the problems of low efficiency, high cost, large toxic and side effects on human body and the like

Active Publication Date: 2012-04-11
广东康乃欣生物医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 3. It is not easy to degrade, has corrosion, and the discharge will pollute the environment
[0007] 4. High cost, low efficiency, and time-consuming
The indiscriminate use of antibiotics not only makes the strains resistant, but also has great toxic and side effects on the human body.

Method used

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  • Protamine compounded preparation, preparation method and application thereof
  • Protamine compounded preparation, preparation method and application thereof
  • Protamine compounded preparation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Protamine compound preparation of the present invention is made up of the content of following percentage by weight:

[0154] Proportion:

[0155]

[0156] Method: In a sterile room or ultra-clean workbench, accurately weigh the above reagents, protamine 0.3g, water-soluble chitosan 1.9g, glycine 1.1g, monoglyceride 0.5g, sodium acetate 0.1g, acetic acid 0.1g, 96ml (96g) of sterilized distilled water, put it into a clean glass or stainless steel container, stir gently, mix well, and then pack it into a sterile container.

[0157] Application: This formula can be used to make skin and mucous membrane bactericidal disinfectant, which can kill Staphylococcus aureus, Candida albicans, and Escherichia coli on the surface of skin and mucous membranes within 2-10 minutes, with a killing rate of 99.8%. It can treat abscesses, psoriasis, ulcers, bedsores, scalds, burns, boils, oral ulcers, cuts, vaginitis, oral diseases caused by various bacterial infections, and prevent sex...

Embodiment 2

[0159] Protamine compound preparation of the present invention is made up of the content of following percentage by weight:

[0160] Proportion:

[0161]

[0162] Method: Put 10g of acetic acid into a clean glass or stainless steel container in a sterile room or ultra-clean workbench, add 67ml of sterilized distilled water, stir gently, mix well, and then add 10g of water-soluble chitosan After homogenization, add 0.01g of protamine, 10g of glycine, 0.1g of monoglyceride, and 2.89g of sodium acetate, mix thoroughly and evenly, and pack it into a sterile container.

Embodiment 3

[0164] Protamine compound preparation of the present invention is made up of the content of following percentage by weight:

[0165] Proportion:

[0166]

[0167] Method: Mix it evenly in the same way as 1 and 2 above, put it into a sterile liquid-carrying container and seal it.

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Abstract

The invention discloses protamine compounded preparation, a preparation method and application thereof. The protamine compounded preparation of the invention can be singly prepared with the protamine and chitosan, or prepared by compounding one or mixture of over two of glycine, sodium acetate, undecynol monoglyceride, acetic acid, absolute alcohol, lysostaphin, lysozyme, anti-bacterial peptide and sterilized distilled water. The method for preparing the protamine compounded preparation comprises the following steps: accurately weighting each component according to rate in aseptic or clean workshops; putting in clean glass or stainless steel, and uniformly stirring; and sealing in sterile containers. The product not only effectively kills the gram-positive cocci, such as staphyloccocus aureus rosenbach, monilia albican, neisseria gonorrhoeae, streptococcus, anaerobic bacteria, pseudomonas aeruginosa, escherichia coli, pneumococcus, D enterococcus, staphylococcus tetragenus, listeria monocytogenes, stenotrophomonas maltophilia and stomach helicobacter pylori, but also kills the gram-negative bacteria.

Description

technical field [0001] The invention relates to a protamine compound preparation, a method for preparing the protamine compound preparation, and an application of the protamine compound preparation. Background technique [0002] Most of the traditional disinfectants currently on the market contain chemical reagents such as chlorine, alcohols, classics, aldehydes, and phenols. Such as phenols, acids, and alcohols that coagulate proteins to denature them for disinfection; sodium hydroxide, lime, etc. that dissolve proteins; strong oxidation bleaching powder, peracetic acid, etc.; formalin and protein amino binding, glutaraldehyde and microorganisms Protein reaction and other disinfection reagents. [0003] There are one or more of the following shortcomings in the vast majority of the above disinfection reagents: [0004] 1. There are residues and toxic side effects for disinfection patients. [0005] 2. Strong irritation to skin mucous membranes, wounds and wounds. [000...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N63/02A01N43/16A01N61/00A01P1/00A61K38/17A61K38/03A61K38/47A61K8/73A61K8/66A61K8/64A61Q11/00A61P1/02A61P1/04A61P11/00A61P11/02A61P15/02A61P17/00A61P17/02A61P17/10A61P27/02A61P27/16A61P31/02A61P31/04A61P31/10A23L1/09
CPCY02A50/30
Inventor 吴红军张祝妹
Owner 广东康乃欣生物医疗科技有限公司
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