Composite solution with combined application of recombinant III-type humanized collagen and hyaluronic acid and preparation process of composite solution

Abstract

The invention discloses a composite solution with combined application of recombinant III-type humanized collagen and hyaluronic acid and a preparation process of the composite solution, and relates to the technical field of medical cosmetology. A physiological buffer solution is used as a solvent, and comprises the following components by concentration: 0.1-10g / L of recombinant III-type humanized collagen; 1 to 20 g / L of sodium hyaluronate; 1-5 g / L of glutathione; the concentration of tranexamic acid is 0.05 to 0.3 g / L; 8-10g / L of sodium chloride; sodium dihydrogen phosphate is 0.05 to 0.1 g / L; and 0.15 to 0.25 g / L of disodium hydrogen phosphate. According to the composite solution combining the recombinant III-type humanized collagen and the hyaluronic acid, the sodium hyaluronate is used as a filling support, the water absorption and moisturizing performance is excellent, the moisturizing and anti-wrinkle effects are achieved immediately after injection, and the preparation method is simple and easy to operate. Then the occupation effect of the recombinant III-type humanized collagen, glutathione and other substances stimulates the body to synthesize collagen, and tranexamic acid has the effects of resisting allergic reaction and diminishing inflammation, so that the problems of moisturizing and wrinkle resistance of the skin are fundamentally solved.

Description

technical field [0001] The invention belongs to the technical field of medical cosmetology, and particularly relates to a composite solution for combined application of recombinant type III humanized collagen and hyaluronic acid and a preparation process thereof. Background technique [0002] Hyaluronic acid, also known as hyaluronic acid, is the most representative type of mucopolysaccharide. It is widely distributed in various parts of the human body. With its unique molecular structure and physical and chemical properties, it shows a variety of important physiological functions in the body, such as lubricating joints. , regulate the permeability of the blood vessel wall, regulate protein, water and electrolyte diffusion and operation, and promote wound healing. In addition, hyaluronic acid has a special water-locking effect and is the best moisturizing substance found in nature. It is called an ideal natural moisturizing factor. For example, a 2% pure hyaluronic acid aque...

AI Technical Summary

Problems solved by technology

However, the collagen obtained through the bacterial expression system has biological safety problems such as endotoxin and pyrogen, which make the production and testing costs of the product high, and there are hidden dangers. The expressed protein exists in the bacterial cells in the form of inclusion bodies, and the purification of the product is difficult. Recycling The rate is limited, and the prokaryotic expression system is relatively low-level, and the post-translational processing and modification of the expression product cannot be completed, so that the product does not have biological activity

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