Oral care composition

An oral care and composition technology, applied in the field of oral care compositions, can solve problems such as disorder

Active Publication Date: 2020-02-07
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various attempts to remineralize teeth have been extensively studied, but the HAP crystallites formed in the remineralized layer are less ordered and far less enamel-like than those in natural enamel. Structure

Method used

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  • Oral care composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0097] This example illustrates the effect of silicate sources on tooth enamel remineralization.

[0098] Preparation of remineralization solution

[0099] material

[0100] Unless specifically mentioned, all chemicals used in this study were purchased from Aladdin Reagent (Shanghai, China) and were of analytical grade. Use three times distilled water and filter all solutions through a 0.22μm Millipore membrane before use.

[0101] Remineralization solution

[0102] The remineralization solution is prepared by mixing equal volumes of calcium-containing solution (Ca solution) and phosphate-containing neutralized buffer solution (P solution). By dissolving the calculated amount of CaCl 2 And MgCl 2 ·6H 2 O, prepare calcium solution. By using Na 2 HPO 4 , KCl, NaCl, Na 2 SO 4 , NaHCO 3 , Glutamic acid (Glu), polyacrylic acid (PAA) and tris(hydroxymethyl)aminomethane (Tris, from Sigma-Aldrich, St. Louis, Missouri, USA) to prepare a phosphate-containing solution. Before mixing, the sodi...

Embodiment 2

[0114] This example demonstrates the effect of polyacrylic acid on the remineralization of tooth enamel.

[0115] Preparation of remineralization solution

[0116] As described in Example 1, the same protocol was used to prepare the remineralization solution. After mixing, the final concentration of each substance in the remineralization solution is listed in Table 1. The concentrations of Glu, silicate ion and PAA in different samples are listed in Table 3.

[0117] table 3

[0118]

[0119] method

[0120] As described in Example 1, the same protocol was used to evaluate the remineralization of enamel.

[0121] result

[0122] After 6 days of treatment with different remineralization solutions, SEM images showed that new layers were formed on all enamel plates. For sample 6, in the absence of PAA, no ordered structure was observed on the enamel surface. For samples 7 and 8 containing PAA, it was shown that orderly flaky crystallites were formed. Moreover, as the concentration of...

Embodiment 3

[0125] This example demonstrates the effect of glutamic acid, silicate source and polyacrylic acid on the remineralization of tooth enamel.

[0126] Preparation of remineralization solution

[0127] As described in Example 1, the same protocol was used to prepare the remineralization solution. After mixing, the final concentration of each substance in the remineralization solution is listed in Table 1. The concentrations of Glu, silicate ions and PAA in different samples are listed in Table 4.

[0128] Table 4

[0129]

[0130] method

[0131] As described in Example 1, the same protocol was used to evaluate the remineralization of enamel.

[0132] result

[0133] After 6 days of treatment with different remineralization solutions, SEM images showed that new layers were formed on all enamel plates. For sample 10 containing 10 mM Glu, no ordered structure was observed to be formed on the enamel surface. For samples 7 and 9 containing a higher concentration of Glu, it was shown that ...

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PUM

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Abstract

An oral care composition is disclosed comprising from 0.01 to 50% by weight of a calcium source, a water soluble phosphate source, a water soluble silicate source and from 0.01 5 to 10% by weight of an amino acid or its physiologically acceptable salt or a mixture thereof, wherein the calcium source is calcium hydroxide, calcium oxide, calcium glycerophosphate, calcium lactate, calcium sulfate, calcium salts of citric acid, calcium chloride, calcium nitrate, calcium acetate, calcium gluconate, calcium formate, calcium malate, calcium propionate, calcium butyrate, calcium bicarbonate, monocalcium phosphate anhydrous, dicalcium phosphate anhydrous, tricalcium phosphate, octacalcium phosphate, calcium silicate, calcium carboxymethyl cellulose, calcium alginate, calcium carbonate or mixtures thereof; wherein the phosphate source is trisodium phosphate, monosodium dihydrogen phosphate, disodium hydrogen phosphate, ammonium phosphate, diammonium hydrogen phosphate, ammonium dihydrogen phosphate, tripotassium phosphate, monopotassium dihydrogen phosphate, dipotassium hydrogen phosphate or a mixture thereof; wherein the silicate source is sodium silicate, potassium silicate, tetraethylorthosilicate, tetraethylsilicate or mixtures thereof; and wherein the amino acid is selected from acidic amino acid, neutral amino acid or a mixture thereof.

Description

Technical field [0001] The present invention relates to oral care compositions such as toothpaste, chewing gum, mouthwash and the like. Specifically, the present invention relates to an oral care composition comprising a calcium source, a water-soluble phosphate source, a water-soluble silicate source and an amino acid. The invention also relates to the use of this composition in the remineralization and / or whitening of personal teeth. Background technique [0002] Many products that people consume have a negative impact on our teeth and oral cavity. For example, acidic beverages and sweets can attack teeth by attacking tooth enamel, which is the outer coating that protects teeth. In addition, tobacco products and beverages such as coffee and tea can contaminate people's teeth or reduce their whiteness. These staining and discoloring substances are usually able to penetrate into the enamel layer. This problem occurs gradually over the years, but it makes the enamel of the tee...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/24A61K8/25A61K8/19A61Q11/00A61K31/198
CPCA61K8/24A61K8/25A61Q11/00A61K8/19A61K31/198
Inventor 李小科唐睿康王进防王亚楠徐旭荣张美丽
Owner UNILEVER IP HLDG BV
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