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Absorbable suture containing PHBHHx/PLA (poly-3-hydroxybutyrate-co-3-hydroxyhexanoate/polylactic acid)

A suture thread and monofilament fiber technology, applied in filament/thread forming, conjugated synthetic polymer artificial filament, single-component copolyester artificial filament, etc., can solve problems such as insufficiency and achieve complementary material properties , High mechanical strength, simple spinning process

Inactive Publication Date: 2015-11-18
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PHBV and PHBHHx, that is, medium-chain PHA, have high mechanical strength, but are slightly insufficient in flexibility and degradability. Especially, PHBHHx contains more 3-HHx and has a longer carbon chain, and the degradation time is longer than PHBV. Therefore, blending PHBV and PHBHHx with other materials to obtain complementary properties can expand their application fields

Method used

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  • Absorbable suture containing PHBHHx/PLA (poly-3-hydroxybutyrate-co-3-hydroxyhexanoate/polylactic acid)
  • Absorbable suture containing PHBHHx/PLA (poly-3-hydroxybutyrate-co-3-hydroxyhexanoate/polylactic acid)
  • Absorbable suture containing PHBHHx/PLA (poly-3-hydroxybutyrate-co-3-hydroxyhexanoate/polylactic acid)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1, PHBHHx monofilament fiber

[0053] PHBHHx (the weight-average molecular weight is 230000, the number-average molecular weight is 125000, the polydispersity coefficient is 1.8, the mass percentage composition of 3-hydroxycaproic acid is 12%) joins the extruder of laboratory model (Ruojiang Chemical Fiber Company, Beijing, China) Press, extrude at 130°C in a spinneret hole with an inner diameter of 1 mm, wind up at a speed of 100 cm / min and quench in ice water at 0°C to obtain non-crystalline primary spinning. The extrusion speed is 60cm / min. Isothermal crystallization in ice bath for 3h and post-stretching. Under tension-maintaining conditions, anneal at room temperature for one day. The stretching speed is 10 m / min, and the diameter of the stretched monofilament fiber is 60 μm to 500 μm.

[0054] The performance of the monofilament fiber prepared in this embodiment is tested below.

[0055] (1) The scanning electron micrographs of the monofilament diam...

Embodiment 2

[0065] Embodiment 2, PHBHHx / PLA monofilament fiber

[0066] 10wt% PHBHHx (the weight-average molecular weight is 230000, the number-average molecular weight is 125000, the polydispersity coefficient is 1.8, the mass percent content of 3-hydroxyhexanoic acid is 12%) and 90wt% PLA (the molecular weight is 120000, wherein L- The mass percent content of isomer is 48%) after melting, granulate, add extruder at 130°C, extrude in the spinneret hole of 1mm inner diameter, wind with 40~50cm / min speed and quench in 0°C water Cold, to obtain non-crystalline primary spinning. The extrusion speed is 60cm / min. Isothermal crystallization in ice bath for 5h and post-stretching. Under tension-maintaining conditions, anneal at room temperature for one day. The stretching speed is 12 m / min, and the fiber diameter after stretching is 50 μm to 300 μm.

[0067] The performance of the monofilament fiber prepared in this embodiment is tested below.

[0068] (1) The scanning electron micrographs ...

Embodiment 3

[0074] Embodiment 3, PHBV / PLA bundle fiber

[0075] Get 10~30wt% PHBV (molecular weight 500000, wherein the mass percent content of 3-hydroxyvaleric acid ester is 12%) and 70~90wt% PLA (molecular weight is 120000, wherein the mass percent content of L-optical isomer is 48%) mixed in a high-speed mixer, injected into a twin-rod extruder to melt, extruded through 24-hole or 72-hole spinneret holes, the extrusion speed is 1000m / min, and then drawn twice under the condition of 65°C After heat setting, the obtained fiber diameter is 12-16 μm.

[0076] The properties of the bundled fibers prepared in this example are tested below.

[0077] (1) The scanning electron micrographs of PHBV / PLA bundled fibers (2 / 8, m / m) with a single fiber diameter of 12 to 16 μm prepared in this example are as follows Figure 5 shown.

[0078] (2) The mechanical properties of the PHBV / PLA bundled fibers prepared in this example are shown in Table 3.

[0079] The mechanical properties of each fiber bu...

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Abstract

The invention discloses an absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate) (PHBV (Polyhydroxylbutyrate Valerate) or PHBHHx (poly (3-hydroxybutyrate-co-3-hydroxyhexanoate))). The invention specifically discloses a PHBHHx monofilament fiber, a PHBHHx / PLA (Poly Lactic Acid) monofilament fiber and a PHBV / PLA bunched fiber and preparation methods thereof. Blending with the PLA is performed, so that a spinning process is simple, complementary material performance is achieved, and the PHBHHx and the PHBV fibers are good in handfeel. Compared with the conventional material, the absorbable suture has the advantage of higher biocompatibility in the field of nerve and vascular repair due to the use of the PHA material. Moreover, the PHA is high in mechanical strength and slow in degradation speed, so that the PHA is excellent in application effect on the suture repair of cartilages and bone tissues. On the aspect of novel minimally invasive surgical repair, the PHBHHx and the PHBV contain nontoxic and non-irritant degradation products with high compatibility, so that surgical scars can be effectively reduced, and the absorbable suture has an application prospect in esthetic restoration.

Description

[0001] This application is a divisional application with the application number 201310526584.1, the application date is October 30, 2013, and the invention name is "A kind of absorbable suture containing medium-chain PHA". technical field [0002] The invention relates to a bioabsorbable material, in particular to an absorbable suture thread containing medium-chain PHA. Background technique [0003] Surgical sutures are divided into absorbable sutures and non-absorbable sutures according to absorbability. Non-absorbable sutures offer good tensile strength, but are limited by the need for reoperation to remove surgical sutures after surgery. Absorbable sutures can be selected according to the surgical site, suturing requirements, healing speed, etc., and the sutures that match the degradation speed and strength will be degraded and absorbed after the operation is completed. [0004] The biggest limitation in the development of absorbable sutures lies in the following aspects...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D01F6/84D01F8/14D01D5/08D01D5/28A61L17/12A61L17/10
Inventor 何钰吴琼任梦达丁长坤
Owner TSINGHUA UNIV
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