96 results about "Hydroxybutyrates" patented technology

Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and / or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

The application provides a preparation method of piezoelectric nanofiber aerogel, comprising the following steps: S1, zinc oxide is added into hexafluoroisopropanol, polyhydroxybutyrate is added after ultrasonic dispersion, and magnetic stirring is conducted to obtain a PHB@ZnO solution; S2, the PHB@ZnO solution is prepared into a nanofiber membrane through electrospinning, the nanofiber membrane is placed into a vacuum drying box for vacuum drying to obtain a PHB@ZnO nanofiber membrane; S3, the PHB@ZnO nanofiber membrane is added into deionized water, and a short PHB@ZnO nanofiber dispersion liquid is obtained after homogenization; S4, chitosan powder is added into deionized water, glacial acetic acid is added after stirring, and chitosan solution is obtained after continuous stirring; S5, the short PHB@ZnO nanofiber dispersion liquid, the chitosan solution and glutaraldehyde are uniformly mixed to obtain a mixture, the mixture is poured into a mold, the mold is placed into a freeze dryer for freeze drying to obtain piezoelectric nanofiber aerogel. The piezoelectric nanofiber aerogel prepared by the piezoelectric nanofiber aerogel has a porous structure and good piezoelectric performance, and can accelerate bone defect repair.

A poly(3-hydroxyalkanoate) resin composition comprising: a copolymer (A) of 3-hydroxybutyrate units and other hydroxyalkanoate units, and a copolymer (B) of 3-hydroxybutyrate units and other hydroxyalkanoate units, wherein the content of other hydroxyalkanoate units in copolymer (A) is 1 to 6 mol%, and the content of other hydroxyalkanoate units in copolymer (B) is 24 mol% or more. The resin composition further comprises layered clay mineral (C). The proportion of (A) is 72 to 93 wt%, and the proportion of (B) is 7 to 28 wt%. The content of (C) is 5 to 45 parts by weight relative to 100 parts by weight of the total poly(3-hydroxyalkanoate) resin composition.

Provided is a fiber containing a poly (3-hydroxyalkanoate)-based resin, the fiber containing a poly (3-hydroxyalkanoate)-based resin containing a 3-hydroxybutyrate unit, the fiber being suppressed in melt adhesion during the production of the fiber and being capable of being thermally fused under low-temperature conditions during thermal processing of the fiber. The present invention is a fiber having a core-sheath structure including a core part and a sheath part, the core part and the sheath part each containing a poly (3-hydroxyalkanoate)-based resin including a 3-hydroxybutyrate unit, the average molar content of 3-hydroxybutyrate units in the poly (3-hydroxyalkanoate)-based resin in the core part is greater than the average molar content of 3-hydroxybutyrate units in the poly (3-hydroxyalkanoate)-based resin in the sheath part.

Provided is an implant comprising a first biodegradable polymer and a second biodegradable polymer wherein the first biodegradable polymer comprises a copolymerized polyhydroxyalkanoate (PHA) and the copolymerized PHA comprises from 0.1 to 50 wt%, based on the total weight of the copolymerized PHA, of recurring units derived from 4-hydroxybutyrate (4-HB).

Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

A process for producing polyhydroxyalkanoates, comprising the steps of: fermenting production medium comprising pongamia oil using bacteria from the Cupriavidus, Burkholderia, or Alcaligenes genera capable of producing polyhydroxyalkanoates; wherein the pongamia oil is extracted from the seeds of Pongamia species and clarified by filtering before the crude, unprocessed pongamia oil is added to the production medium; and extracting the polyhydroxyalkanoates comprising a homopolymer comprising a 3-hydroxybutyrate (3HB) unit amongst other sole PHB polymers from within the bacteria.

A resin composition for injection molding contains a poly(3-hydroxyalkanoate) resin. The poly(3-hydroxyalkanoate) resin includes at least one copolymer of 3-hydroxybutyrate units and other hydroxyalkanoate units. The average content of the 3-hydroxybutyrate units in the poly(3-hydroxyalkanoate) resin is from 92 to 99 mol %. The polystyrene-equivalent weight-average molecular weight of the poly(3-hydroxyalkanoate) resin, as measured by gel permeation chromatography using a chloroform solvent, is from 21×104 to 38×104. In a weight molecular weight distribution of the poly(3-hydroxyalkanoate) resin, the proportion of a component having a weight molecular weight of 20×104 or less is from 35 to 60 wt %.

To provide a biomass-derived plasticizer for polyester resins with excellent plasticization efficiency. [Solution] A plasticizer containing 3-hydroxybutyrate ester is prepared as a plasticizer for plasticizing polyester resins. The 3-hydroxybutyrate ester may also contain R-3-hydroxybutyrate ester. The 3-hydroxybutyrate ester may also contain 3-hydroxybutyrate alkyl ester. The 3-hydroxybutyrate alkyl ester may contain 3-hydroxybutyrate C 1-24 Alkyl esters (especially 3-hydroxybutyrate C) 1-6 It may also contain alkyl esters. A polyester resin composition comprising a polyester resin and the plasticizer may be prepared. The polyester resin may include a biodegradable polyester resin such as polylactic acid. The mass ratio of the polyester resin to the plasticizer may be 99 / 1 to 80 / 20. A molded article containing the polyester resin composition may be prepared.

The invention provides a polyhydroxyalkanoate composition, a preparation method of the polyhydroxyalkanoate composition, a biodegradable plastic product and application of the biodegradable plastic product. The biodegradable plastic product is prepared by the following method which comprises the following steps: mixing at least two copolymers of 3-hydroxybutyrate and 4-hydroxybutyrate, melting, extruding and granulating to obtain polyhydroxyalkanoate particles; the at least two copolymers of 3-hydroxybutyrate and 4-hydroxybutyrate at least comprise a block copolymer of which the mass percentage content of a 4-hydroxybutyrate structural unit is 0-20%, and at least comprise a random copolymer of 3-hydroxybutyrate and 4-hydroxybutyrate; forming the polyhydroxyalkanoate particles to obtain a preformed part; and carrying out post-treatment on the preformed part to obtain the biodegradable plastic product. The biodegradable plastic product has the advantages of excellent toughness, low migration volume, good processing molding performance and low odor.

An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

Provided are: a fabric that has strength sufficient for practical use as clothing or industrial materials and also has excellent color fastness while containing PHA fibers having marine biodegradability; and a dyeing method for obtaining said fabric. The present invention pertains to a dyed fabric which includes polyhydroxyalkanoate fibers including 3-hydroxybutyrate as a monomer unit and having a degree of crystallinity of 50% or more and which exhibits a K / S value of 2 or more. The present invention also pertains to a dyeing method for a fabric which includes polyhydroxyalkanoate fibers including 3-hydroxybutyrate as a monomer unit and having a degree of crystallinity of 50% or more. In the dyeing method, the temperature of a dyeing solution during dyeing is 86-120°C.

The objective of the present invention is to provide a novel production method allowing a molded body containing a P3HB-based resin to be obtained using an injection blow molding method, and a technique for using the same. The above problem is solved by providing a method for producing a molded body containing a P3HB-based resin, the method comprising the steps (A) to (C): (A) the step of plasticizing a resin composition containing a P3HB-based resin; (B) the step of injection molding the plasticized resin composition obtained in the previous step (A), to obtain a preform; and (C) the step of blow-forming the preform obtained in the previous step (B), to obtain a molded body.

A resin composition contains: a copolymer (A) that is a copolymer of 3-hydroxybutyrate units and other hydroxyalkanoate units and in which the proportion of the other hydroxyalkanoate units is 24 mol % or more; a copolymer (B) that is a copolymer of 3-hydroxybutyrate units and other hydroxyalkanoate units and in which the proportion of the other hydroxyalkanoate units is from 1 to less than 5 mol %; and a copolymer (C) that is a copolymer of 3-hydroxybutyrate units and other hydroxyalkanoate units and in which the proportion of the other hydroxyalkanoate units is from 5 to less than 24 mol %. The copolymer (A) has a weight-average molecular weight of 10×104 to 50×104. At least one or all of the copolymers (A), (B), and (C) are reaction products resulting from a reaction with an organic peroxide.

The present invention provides pharmaceutical compositions and methods for treating fatigue or excessive daytime sleepiness associated with narcolepsy. [Solution] A pharmaceutical composition comprising an immediate-release component containing 4-((L-valyl)oxy)butanoic acid and a controlled-release component containing 4-((L-valyl)oxy)butanoic acid, as well as the pharmacokinetics of 4-((L-valyl)oxy)butanoic acid and γ-hydroxybutyrate after oral administration of the pharmaceutical composition are disclosed.

The application relates to the technical field of slow-release hydrogels, and discloses a periodontal local drug slow-release hydrogel based on chitosan and application thereof, which is prepared from the following components: triple modified chitosan, functional filler, therapeutic drug, crosslinking agent and deionized water; the triple modified chitosan is carboxymethylization-mussel biomimetic polyphenol-poly-beta-hydroxybutyrate triple modified chitosan, and the functional filler is a composite powder of hydroxyapatite and carboxylated graphene oxide loaded with nano-silver; the technical scheme of the application solves the technical problems of poor water solubility, insufficient wet adhesion, short slow-release period and single function of the existing chitosan hydrogel, the prepared hydrogel is suitable for the physiological environment of periodontal local, has excellent biocompatibility, structural stability, long-acting slow-release property and multifunctional synergy, provides a brand-new effective carrier for long-acting local treatment of periodontitis, and has extremely high practical value and popularization prospect in the field of oral clinical treatment.

The present invention relates to a nutritional composition comprising 3-hydroxybutyric acid for use in improving the gastrointestinal barrier. In particular, the present invention relates to improving the gastrointestinal barrier in an individual, preferably an infant or a child.

The present disclosure relates to highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate and biomedical uses thereof. In particular highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate, is provided for enhancing bodily function and treating various disease states. The methods described herein provide for production of a highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate via processes external to the human body and administering effective amounts of highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate to human subjects to achieve a range of therapeutic benefits, including but not limited to, one or more of: inhibiting inflammasome activation, reducing pro-inflammatory cytokines, improving insulin sensitivity, enhancing mitochondrial biogenesis, and promoting muscle protein synthesis. Additionally, highly purified (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate is administered in an amount and frequency conducive to one or more of: improving cognitive function, reducing oxidative stress, enhancing cardiovascular health, and supporting neuroprotection. Methods for manufacturing and purifying (R)-3'-hydroxybutyl (R)-3'-hydroxybutyrate compositions to ensure high specificity and efficacy in therapeutic applications are also provided.

The application provides a preparation and application method of an amino hybrid SiO2 aerogel for purifying propylene in poly-3-hydroxybutyrate pyrolysis gas. In view of the problems that the existing amino adsorption material has poor selectivity in a complex biomass pyrolysis gas environment, the adsorption capacity is not optimized for specific components, and there is a lack of special technical scheme for carbon capture in the resourceization process of PHB waste, the amino hybrid SiO2 aerogel with a specific hierarchical porous structure is prepared by an in-situ polymerization method, and is specially used for treating specific component flue gas generated by high-temperature pyrolysis of PHB. The method fully utilizes the strong structural stability of the amino hybrid aerogel, the high selectivity of the amino active site, and the promotion effect of water vapor in the flue gas on the amino adsorption of CO2, and realizes high-capacity and high-selectivity capture of CO2 in the presence of propylene and other interfering gases. The application provides an efficient carbon capture solution for the resourceization treatment of biobased plastic waste.

A foodstuff can include a free acid β-hydroxybutyrate, and a base. The β-hydroxybutyrate, and base, are present at a less than 1:1 molar equivalence. Ketone Ester may also be incorporated as a component of the foodstuff.

The invention relates to an adaptive evolution culture method of Halomonas and application of the Halomonas in preparation of PHB, and belongs to the technical field of biology. According to the method, the red algae are pretreated with the acid with the specific concentration, the hydrolysis rate of the red algae can be increased, and more raw materials are provided for PHB preparation. According to the invention, the halomonas is subjected to 35 times of adaptive evolution culture in the red algae pre-hydrolysate, so that the tolerance and transformation capability of the strain to an inhibitor are improved, the prepared culture solution containing the halomonas evolved strain is used for preparing PHB (poly-3-hydroxybutyrate), and the yield of the PHB can be obviously improved. According to the method, the PHB is prepared by fermentation of the Halomonas evolved strain, the red algae are taken as the raw material, the hydrolysate obtained by pre-hydrolysis does not need solid-liquid separation, and fermentation is performed after enzymolysis of cellulase, so that more raw materials can be released, the content of the PHB is further increased, the utilization rate of the red algae is increased, and meanwhile, the preparation process steps are simplified.

Compositions for improving metabolic function in a subject include optically pure S-beta-hydroxybutyrate or non-racemic mixtures enriched with the S-enantiomer. S-beta-hydroxybutyrate in pure or enriched form provides energy to the heart, dilates the arteries, decreases blood pressure and systemic vascular resistance, and increases cardiac output. S-Beta-hydroxybutyric acid is more rapidly absorbed and utilized by the body than salts or esters, enhances taste, and reduces the need to include citric acid or other edible acids. S-Beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and provide one or more electrolytes. S-Beta-hydroxybutyrate esters provide more controlled release without adding electrolytes. Compositions for improving heart function in a subject may contain a dietetically or pharmaceutically acceptable carrier and optically pure S-beta-hydroxybutyrate or non-racemic mixture enriched with S-beta-hydroxybutyrate, wherein the compositions contain from about 50.5% to 100% by enantiomeric equivalents of S-beta-hydroxybutyrate and from about 49.5% to 0% by enantiomeric equivalents of R-beta-hydroxybutyrate.

The application discloses a production method of high-performance recyclable BOPP film, and the high-performance recyclable BOPP film comprises an outer layer, a middle layer and an inner layer; the outer layer is composed of homopolymer polypropylene, polylactic acid, polyhydroxybutyrate, polypropylene carbonate, polystyrene-acrylonitrile copolymer, an antioxidant, an ultraviolet absorber and a slip agent; the middle layer is composed of homopolymer polypropylene, thermoplastic starch, polycaprolactone, polyethylene terephthalate, maleic anhydride grafted polypropylene, a fiber reinforcing agent and methyl methacrylate-butadiene-styrene copolymer; and the inner layer is composed of random copolymer polypropylene, polybutylene succinate, polyvinyl alcohol, PA6, an antistatic agent and an antibacterial agent. The BOPP film prepared by the method has good performance, is environment-friendly and recyclable.

The present invention relates to a biodegradable coating composition, a method for preparing the same, and a biodegradable article using the same. In particular, according to an embodiment of the present invention, the biodegradable coating composition is a copolymer polyhydroxyalkanoate (PHA) resin including a PHA resin, a surfactant, inorganic particles, and a rheology modifier, and includes 4-hydroxybutyrate (4-HB) repeating units. By using a PHA resin having a weight average molecular weight of 10,000 g / mol to 12,000,000 g / mol, the biodegradable coating composition is environmentally friendly due to excellent biodegradability and biocompatibility, and can have improved dispersibility, coating properties, oil resistance, and processability.

The present invention addresses the problem of providing: a continuous long fiber comprising an aliphatic copolyester, which has excellent storage stability and is capable of solving the problem of poor unwinding; and a method for producing the continuous long fiber. This continuous long fiber is composed of an aliphatic copolyester, and the aliphatic copolyester contains 3-hydroxybutyrate as a first monomer unit and 4-hydroxybutyrate or 3-hydroxyvalerate as a second monomer unit, and when the second monomer unit is a 4-hydroxybutyrate unit, the aliphatic copolyester contains 3-hydroxybutyrate or 3-hydroxyvalerate as a second monomer unit, and when the second monomer unit is a 3-hydroxybutyrate unit, the aliphatic copolyester contains 3-hydroxybutyrate or 3-hydroxyvalerate or 3-hydroxyvalerate as a third monomer unit. When the second monomer unit is 3-hydroxyvalerate, the proportion of the second monomer unit relative to all the monomer units is 1-9 mol%, and when the second monomer unit is 3-hydroxyvalerate, the proportion of the second monomer unit relative to all the monomer units is 1-7.6 mol%.

The present disclosure relates to biomedical and nutritional uses of highly purified (R)-3′-hydroxybutyl (R)-3′-hydroxybutyrate and (R)-3-hydroxybutyrate. In some embodiments, these compounds are employed for enhancing bodily functions and treating various disease states, including cognitive function, muscle power output, inflammation reduction, metabolic disorders, and mitochondrial function. The methods involve combining these ketone esters with natural supplements or medications to improve health outcomes. The disclosure further includes processes for manufacturing and purifying these compounds to ensure high specificity and efficacy in therapeutic applications, providing a comprehensive and enhanced strategy for advancing health and treating diseases.

The present invention provides a compound for use in reducing liver fat in a subject, wherein the compound is selected from:(i) (R)-3-hydroxybutyrate;(ii) an ester of (R)-3-hydroxybutyrate; and(iii) an oligomer obtainable by polymerising (R)-3-hydroxybutyrate moieties;or a pharmaceutically acceptable salt or solvate thereof. The compound is particularly useful in subjects suffering from a fatty liver. The compound can be used to treat non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH) or non-alcoholic fatty liver (NAFL).

The present invention aims to provide a novel production method capable of obtaining a molded body containing a P3HB-based resin using an injection blow molding method and a technology using the same. The present invention solves the above problem by providing a production method of a molded body containing a P3HB-based resin, the method comprising the following steps (A) to (C): (A) a step of plasticizing a resin composition containing a P3HB-based resin, (B) a step of injection molding the plasticized resin composition obtained by the above step (A) to obtain a preform, and (C) a step of blow molding the preform obtained by the above step (B) to obtain a molded body.

In various implementations, a composition comprising R-beta-hydroxybutyrate, related compounds, and / or one or more other compounds may be administered to an individual to cause weight loss, weight maintenance, elevate blood ketone levels, maintain blood ketone levels, reduce blood glucose levels, maintain blood glucose levels, improve energy, focus, mood, cognitive function, or aide with neurological or inflammatory disorders and / or combinations thereof. The composition may include sodium R-beta-hydroxybutyrate salts; potassium R-beta-hydroxybutyrate; and one or more other salts of R-beta-hydroxybutyrate.