108 results about "Ketone bodies" patented technology

A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises dehydrogenase enzyme that has specificity for the analyte, NAD, an NAD derivative, pyrrolo-quinoline quinone (PQQ), or a PQQ derivative, a tetrazolium dye precursor, a diaphorase enzyme or an analog thereof, and a nitrite salt. The reagent causes dye formation that is a measure of the analyte concentration. The nitrite salt suppresses interfering dye formation caused non-enzymatically by the hemoglobin. Preferably, the reagent is used in a dry strip for measuring ketone bodies, such as beta-hydroxybutyrate.

The present invention is directed to a single test system and method for determining the integrated glycemic condition of a subject by measuring the concentration of glucose and the level of protein-bound glucose in a subject's body fluid, such as whole blood. The glucose concentration is indicative of the subject's immediate glycemic condition, whereas the protein-bound glucose concentration is indicative of either intermediate or long-term glycemic condition. Optionally, other analytes indicative of glycemic condition, such as ketone bodies or fatty acid derivatives, can also be measured. The present invention also provides a method of diagnosing diabetes. The invention additionally provides a method for analyzing the concentration of fructosamine in less than or equal to five minutes without the use of a reaction accelerator.

This invention relates to the field of therapeutic agents for the treatment of Age-Associated Memory Impairment (AAMI). In particular, the present invention utilizes compositions comprising at least one compound capable of elevating ketone body concentrations in a mammal (e.g., ketogenic compounds), administered in an amount effective for treatment or prevention of loss of cognitive function caused by reduced neuronal metabolism in AAMI. In one embodiment, the composition includes medium chain triglycerides (MCT). In another embodiment, the compositions are administered in the presence of carbohydrate. The present invention also relates to oral dosage forms, in particular, a nutritional drink comprising at least one compound capable of elevating ketone body concentrations in a mammal.

Provided are alternative sources of ketone bodies for reducing or eliminating symptoms of Parkinson's disease, amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's disease), Alzheimer's disease, Huntington's disease, epilepsy and other diseases or disorders characterized by impaired glucose metabolism. The alternative sources of ketone bodies include mono-, di- and triglyceride esters of acetoacetate and mixtures thereof, and / or mono-, di- and triglyceride esters of 3-hydroxybutyrate and mixtures thereof. These glyceride esters can be administered orally as a dietary supplement or in a nutritional composition.

A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.

A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R)-hydroxybutyl (3R)-hydroxybutyrate of formula (I) is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of neurodegeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.

A compound which is 3-hydroxybutyl 3-hydroxybutyrate enantiomerically enriched with respect to (3R) hydroxybutyl (3R)-hydroxybutyrate of formula (I): is an effective and palatable precursor to the ketone body (3R)-hydroxybutyrate and may therefore be used to treat a condition which is caused by, exacerbated by or associated with elevated plasma levels of free fatty acids in a human or animal subject, for instance a condition where weight loss or weight gain is implicated, or to promote alertness or improve cognitive function, or to treat, prevent or reduce the effects of, neuro degeneration, free radical toxicity, hypoxic conditions or hyperglycaemia.

Provided are alternative sources of ketone bodies for reducing or eliminating symptoms of Parkinson's disease, amyotrophic lateral sclerosis (ALS, also called Lou Gehrig's disease), Alzheimer's disease, Huntington's disease, epilepsy and other diseases or disorders characterized by impaired glucose metabolism. The alternative sources of ketone bodies include mono-, di- and triglyceride esters of acetoacetate and mixtures thereof, and / or mono-, di- and triglyceride esters of 3-hydroxybutyrate and mixtures thereof. These glyceride esters can be administered orally as a dietary supplement or in a nutritional composition.

The invention discloses multi-item composite quality control liquor for urine analysis. The multi-item composite quality control liquor comprises a buffering solution, a surface active agent, 2-pyridinethiol 1-oxide sodium salt, MgC12, urea, sodium chloride, poloxamer, anhydrous dextrose, bovine serum albumin, esterase, a ketone body substitute, a bilirubin substitute, nitrite, creatinine, a urobilinogen substitute, anhydrous calcium chloride, red blood cell particles, white blood cell particles and crystals. Compared with existing quality control liquor, the multi-term composite quality control liquor can carry out quality control over urine dry chemistry and formal ingredients, and is good in real-time stability, small in toxicity, high in sensitiveness, accurate in detection result, low in production cost and capable of being applied to external quality assessment.

The invention discloses a feed additive capable of increasing the meat factor of pork pigs and improving the meat quality, belonging to the technical field of feed additives. The feed additive comprises pure Chinese herbal medicine powder, lentinan, compound probiotics, a complex enzyme preparation, L-carnitine, beta-carotene, gamma-linolenic oil, vitamin E, vitamin C, ferric sulfate, magnesium sulfate, sodium selenite and carriers, wherein the carriers include rice hull powder, a mixture of rice chaff and husk and kaolin. According to the feed additive, the problem that the meat quality is reduced due to pig feed additives is effectively solved, the anti-stress capacity of the pigs is improved, pig diseases are well prevented and treated, the physique of the pork pigs is improved, and the high-quality pork can be produced; furthermore, the distribution of ketone fat and protein is improved, so that the meat factor of the pork pigs is improved.

Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and / or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.

The invention provides a duck feed which comprises wheat, wheat bran, soybean cake, fish meal, alga fermentation material, organic manganese microelement additive, phytase, beta-mannase, sodium butyrate, vitamin D, calcium chloride, calcium hydrophosphate, table salt and traditional Chinese medicine composition additive. The feed provided by the invention can avoid the adverse side effects on the duck caused by adding toxic additives such as antibiotics and the like, improve the productivity of the duck, promote the healthy growth of the duck, enhance the virus resistance of the duck and improve the meat quality of the ketone body of the duck.

The invention provides ketogenic nutrient meal replacement powder. The ketogenic nutrient meal replacement powder is prepared from the following components: medium chain triglyceride microcapsule powder, gamma-linolenic acid oil microcapsule powder, high oleic sunflower oil microcapsule powder, rice bran fatty alkanol microcapsule powder, oat fiber, soy protein isolate, rice protein, yeast protein, psyllium seed husk powder, a potato extract, an agaricus bisporus extract, a white kidney bean extract, erythritol, grape fruit powder, compound vitamins, compound minerals and xanthan gum. The formula contains high-content fat, contains dietary fiber, various vitamins and minerals, can increase satiety, control the decomposition and absorption of carbohydrates, avoid fat accumulation, and can effectively improve the unwell symptoms of a user when glucose energy supply is converted into ketone body energy to achieve nutrient balance, and can be used as a ketogenic diet for weight loss peopleand epilepsy patients.

The invention relates to the technical field of livestock breeding and in particular relates to a green pork pig feed capable of increasing the lean meat percentage. The feed is prepared from the following raw materials in parts by weight: 10-12 parts of barley malt, 65-70 parts of corn, 12-15 parts of coarse rice powder, 10-12 parts of dried distillers' grains, 10-12 parts of cooked sweet potatoes, 8-12 parts of dried green bean shells, 5-8 parts of dried corn stigmas, 10-12 parts of tomato seed pulp, 12-15 parts of bean pulp, 8-12 parts of carrot residues, 2-3 parts of fresh small carps, 6-8 parts of wax gourd peels, 2-3 parts of meat and bone meal, 2-3 parts of stachyose, 6-8 parts of alligator alternanthera, 8 parts of silphium perfoliatum, a proper quantity of salt and 4-5 parts of a phagostimulant. According to the feed, the raw materials such as the dried corn stigmas, the carrot residues, the alligator alternanthera and the silphium perfoliatum are added, so that the palatability of the feed is improved, the body weight of pig groups is effectively controlled, the overweight of the pig groups is avoided, the lean meat percentage of the fed pig groups is increased, the ketone body fat rate is reduced, and the pork edible value is high; all the raw materials are pure natural green, and the drug residue problem is avoided.

Described herein is the surprising discovery that ketone bodies protect cell and tissues from ionizing radiation. Based on this finding, methods of protecting animal tissue and cells from damage caused by radiation exposure are disclosed which include, contacting the tissue with a therapeutically effective amount of an agent including at least one ketone ester, thereby protecting the tissue from radiation damage. Ketone esters can be used to minimize, reduce and / or prevent tissue damage following intentional and accidental radiation exposure, as well as increasing the therapeutic efficacy of radiation therapies by protecting non-target tissue from incidental radiation damage.

The invention relates to a feed and particularly relates to a green feed capable of increasing a lean meat percentage of fattened pigs. The feed is prepared from raw materials in parts by weight: 65-75 parts of corns, 12-15 parts of cottonseed meal, 3-4 parts of perilla frutescens seeds, 12-15 parts of bean pulp, 12-15 parts of corn straws, 10-12 parts of jumble bead dregs, 8-10 parts of dried apple dregs, 8-12 parts of medicago sativa dried grass, 3-4 parts of orange meal, 8-10 parts of wheat middling, 2-3 parts of dried chrysanthemums, 2-3 parts of fish meal, 2-3 parts of chicken visceral meal, 1-2 parts of medical stone fine powder, 2-3 parts of shrimp shell meal, 1-2 parts of semen cassiae, 8-10 parts of tartary buckwheat, a proper amount of table salt and 4-5 parts of a phagostimulant. The feed has comprehensive and balanced nutrition; nutrition needed by the rapid growth of the fattened pigs can be met; the raw materials including the dried chrysanthemums, the semen cassiae, the tartary buckwheat and the like have the effects of promoting the lipid metabolism capability of pork pigs and the lean meat percentage of a pig ketone body is increased; the palatability of the feed is also improved and the weight is obviously increased; all the raw materials are pure natural green raw materials so that pork is green and safe.

The invention relates to an oral suspension of a liposome-encapsulated insulin lyophilized preparation, named as O-SCULI. The O-SCULI contains lecithin, cholesterol, polyglycol aliphatic acid ester, vitamin E, insulin, water, sodium chloride and phosphate buffer. The invention also provides a two-step process of the O-SCULI, comprising (1) a dewatering / moistening control process: preparing a liposome-encapsulated insulin lyophilized preparation and SCLI so that the encapsulation rate of the insulin is increased to 80 percent by liposome amalgamation; and (2) a respective constant volume / stepped liquefaction process: preparing the SCLI into an O-SCULI oral suspension, preventing the SCLI liposome from leaking and keeping the constant encapsulation rate of the insulin. After a patient acutely takes the O-SCULI, the liposome insulin effectively enters the intestine-hepatic portal vein, the liver and the blood circulation to reduce blood sugar, blood fatty acids and blood ketone with high utilization degree. After a patient continuously orallly takes the oral suspension, the saccharification of hematoglobin, triglyceride and, aminotransferase and the oxidative stress are reduced, the structural damage of liver cells is recovered, and the comprehensive curative effects of diabetes treatment by using various liver functions are improved. The invention also opens up a new path for non-injection administration of active polypeptide protein, such as cytochrome C, albumin, interferon, and the like.

Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the S-enantiomer are formulated to control ketone body levels in a subject. The non-racemic mixture of BHB is enriched with the S-enantiomer to modulate the effect of ketone bodies in the subject and control the rate at which ketosis is achieved. In some aspects a composition for controlling ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of S-beta-hydroxybutyrate and R-beta-hydroxybutyrate, wherein the non-racemic mixture contains from about 52% to 99% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer and from about 48% to about 1% by enantiomeric equivalents of R-beta-hydroxybutyrate enantiomer.

The invention provides feed for improving ketone body quality of broilers. The feed comprises a main feed component, galactomannan, betaine, chromium nicotinate, soya bean lecithin, bee pollen, bone meal, sodium bicarbonate, lucerne meal, an amino acid additive, a vitamin additive, a traditional Chinese medicine feed additive for improving the ketone body quality and flavor of the broilers, and a microbe preparation. The traditional Chinese medicine feed additive and the feed for improving the ketone body quality and flavor of the broilers, which are provided by the invention, have the effects of low toxicity, no side effect and no residue, and can significantly improve the ketone body quality and flavor of the broilers.

The invention relates to the technical field of feeds and particularly relates to a compound feed for improving ketone body quality of meat ducks. The feed is prepared from the following raw materials in parts by weight: 50-60 parts of corns, 12-18 parts of wheat meal, 12-15 parts of black wheat bran, 8-10 parts of corn mushroom residue meal, 20-25 parts of soya bean meal, 8-10 parts of sorghum straws, 6-8 parts of mung bean legumes, 1-2 parts of attapulgite, 1-2 parts of meat and bone meal, 1-2 parts of loach meal, 1-2 parts of freshwater shrimp meal, 1-2 parts of clamshell powder, 2-3 parts of eriocaulon buergerianum, 2-3 parts of sweet potato leaves, 3-4 parts of taro stems and leaves, 1-2 parts of malt, 0.5-1 part of boxthorn leaves, 0.5-1 part of pepper leaves, 1-2 parts of citrus peels, a suitable amount of table salt and 0.2-0.5 part of a phagostimulant. According to the compound feed for improving the ketone body quality of the meat ducks provided by the invention, all the raw materials are pure natural components, and any chemical synthesized medicine is not added; the proportion of a protein raw material is reduced appropriately on the basis of balanced nutrition and the ketone body quality of the meat ducks is improved effectively.

The invention relates to diagnosis test paper for diabetic ketosis and other symptoms of relatively high ketone body. The diagnosis test paper comprises the following reagents: (1) first-phase immersion liquid which comprises a stabilizer and a protective agent, bovine serum albumin, oxalic acid, NAD<+>, NADP<+>, diaphorase, 3-hydroxybutyrate dehydrogenase and buffer solution; and (2) second-phase immersion liquid which comprises NBT, PMS and an organic solvent. The diagnosis test paper is prepared by the following steps of: soaking filter paper in the first-phase immersion liquid, sucking redundant immersion liquid and quickly and warmly drying the soaked filter paper at the temperature of between 20 and 50 DEG C; soaking the dried filter paper in the second-phase immersion liquid and drying at the temperature of between 20 and 50 DEG C again to obtain base paper of the diagnosis test paper; and sticking the base paper on a plastic base and cutting into pieces to obtain the diagnosisreagent strips. The diagnosis test paper can be assembled into various detection devices, has the advantages of convenient operation, fast detection, good sensitivity, high accuracy and the like, cansemiquantitatively detect the 3-hydroxybutyric acid content of milk, urine and blood, and has good application prospect.

The invention provides application of protocatechuic acid as a feed additive in livestock breeding, the protocatechuic acid is used for promoting the growth and development of animals, improving the feed conversion rate, improving ketone body quality and meat quality, comprehensively enhancing animal immunization function and capacity of preventing disease; the toxic and side effect of chemically synthesized organic acid and food potential risk are overcome, the disadvantages that the Chinese herbal medicine additives are complex in component, the use is inconvenient, and the quality standard is hard to control are avoided, the research and development prospect is positive, and the clinical application is wide.

Ketoacidosis is an extreme and uncontrolled form of ketosis, which is a normal response to prolonged fasting. Embodiments of this invention test the ketone level of a patient by measuring the ketone bodies in breath condensation. Some embodiments include a device for medical testing comprising a hollow container, comprising powder mixture of sodium nitroferricyanide, ammonium sulfate and silica and a liquid including an ammonium hydroxide solution.

The invention discloses an anti-diarrhea piglet feed. The feed is prepared from the following components in parts by weight: 670 to 680 parts of soybean meal, 65 to 75 parts of corn germ meal, 20 to 28 parts of stone powder, 18 to 24 parts of soybean oil, 75 to 85 parts of expanded soybean, 28 to 32 parts of fishmeal, 27 to 33 parts of 70% lysine, 0.55 to 0.65 of methionine, 3.2 to 3.6 parts of threonine, 18 to 20 parts of calcium hydrogen phosphate, 15 to 17 parts of salt, 3.15 to 3.25 parts of choline chloride, 18 to 22 parts of premix compound, 1.15 to 1.25 parts of feed additive, 0.55 to 0.65 parts of phytase, 4.5 to 5.5 parts of enzyme preparation, 0.35 to 0 .45 parts of antioxidant, and 1.1 to 1.3 parts of sweetener. The anti-diarrhea piglet feed has the advantages that by using theanti-diarrhea piglet feed disclosed by the invention to feed piglets, the bacterial and viral diarrhea of the piglets can be effectively controlled, and at the same time, the occurrence of yellow-white dysentery and red dysentery of the piglets is reduced, and the disease resistance of the piglets is improved; food intake and appetite of the piglets are improved, piglet growth is promoted, energyand nutrient conversion to muscle tissues is promoted, protein synthesis and deposition are promoted, the ketone body lean rate is increased, the piglet body shape is improved, feed conversion is improved, free radicals are scavenged, meat color is improved, various stress responses of the piglets are relieved, and non-specific immunity of the piglets is increased.

The invention discloses a green and safe pork type pig feed, and relates to the technical field of animal feeds. The green and safe pork type pig feed consists of the following raw materials in parts by weight and compounding ratio: 350-600 parts of corn, 250-400 parts of puffing soybeans, 80-160 parts of wheat bran, 30-80 parts of chaff, 80-160 parts of bean cakes, 22-45 parts of grass meal, 10-26 parts of fish meal, 8-13 parts of choline chloride, 6-10 parts of calcium dihydrogen phosphate, 8-15 parts of stone powder, 3-5 parts of table salt, 5-15 parts of Chinese herbal medicine powder, 8-12 parts of amino acid, 4-6 parts of composite vitamins, 4-6 parts of organic mines, and 0.5-0.8 part of an enzyme preparation. The pig feed disclosed by the invention has the advantages of being comprehensive in nutrient value, high in the efficiency of feed utilization and the like. Chinese herbal medicine powder is added, so that on the basis of improving growing performance, the lean meat percentage of bodies of pigs can be notably improved, and the distribution of body fat and protein is effectively improved; therefore, the flavor of meat quality is improved.

The present invention provides a composition comprising a mixture of an exogenous ketone body, an exogenous NAD modulator and a methyl donor. Typically, exogenous NAD modulator is an exogenous nicotinamide adenine dinucleotide (NAD) precursor. The present invention also provides a method of using such a composition for treating various clinical conditions, including metabolic disorders and neurocognitive impairments. The compositions of the invention can also be used to improve human performance in various competitive or environmental conditions.

The invention relates to a secondary leg-supporting device for livestock, belonging to slaughtering facilities technique, comprising one framework fixed on the chain and lower guide rail on marching type conveyor, one acting vat, the vat body of said vat is connected with chain on the framework, the vat column is hinged with swinging arm, swinging arm is hinged on framework, the other end of swinging arm is equipped with transfer guide rail, said transfer guide rail is corresponding to the break on one-time leg-supporting hook rail of marching type conveyor. It is characterized in that it adds framework, acting vat, swinging arm equipped with transfer rail and break forming one-time leg-supporting hook rail on original marching type conveyor, then it can meet demand of secondary leg supporting, and avoids saw pinching during splitting saw, it needs no additional secondary leg-supporting device, which not only saves operating workers, but also plays effect of original conveyor.

Disclosed herein are “ketonnabidiol” compositions including a combination of: (1) cannabidiol (CBD) and / or cannabidiolic acid (CBDA); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and / or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketonnabidiol compositions for producing desired physiological effects, such as fat loss, in a mammal. The ketonnabidiol compositions beneficially enhance fat loss through ketosis while also reducing the duration and / or severity of unpleasant “keto flu” symptoms typically associated with ketosis.

This invention relates to methods of using genotyping to select patients for treatment with compounds capable of elevating ketone body concentrations in amounts effective to treat reduced neuronal metabolism associated with reduced neuronal metabolism, for example Alzheimer's disease.