High-strength absorbable suture and preparation method thereof

A high-strength suture technology, applied in the field of medical sutures, can solve the problems of affecting use, low tensile strength and elongation of sutures, and inconvenience of clinical treatment, and achieve the effect of complete absorption and high elongation

Active Publication Date: 2015-09-30
温州嘉钮知识产权代理服务有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the existing absorbable sutures use chitosan as the main component, but due to the low tensile strength and elongation of the sutures made of it, it brings inconvenience to clinical treatment and affects the use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A high-strength absorbable suture, consisting of the following components by mass: 39 parts of chitosan, 7 parts of zinc acetate, 2 parts of glutaraldehyde, 11 parts of polyhydroxybutyrate, 2 parts of calcium hydroxyphosphate, Sulfonated castor oil 13 parts, polyglycolide 9 parts, itaconic anhydride 1 part.

[0018] Preparation:

[0019] (1) According to the above mass parts, put chitosan in a reaction kettle and melt it at 150°C, then add zinc acetate, glutaraldehyde, polyhydroxybutyrate, calcium hydroxyphosphate, sulfonated castor oil, polyethylene glycol Lactide and itaconic anhydride were stirred evenly at 100°C to obtain a mixture, wherein the stirring rate was 800r / min;

[0020] (2) Send the mixture obtained in step (1) into a twin-screw extruder for granulation, cool, dry, and cut to obtain masterbatches. The temperature of the twin-screw extruder is 200°C, and the screw speed is 900r / min ;

[0021] (3) Heat the master batch obtained in step (2) to 140°C, pass...

Embodiment 2

[0023] A high-strength absorbable suture, consisting of the following components by mass: 51 parts of chitosan, 16 parts of zinc acetate, 11 parts of glutaraldehyde, 26 parts of polyhydroxybutyrate, 8 parts of calcium hydroxyphosphate, 24 parts of sulfonated castor oil, 17 parts of polyglycolide, 8 parts of itaconic anhydride.

[0024] Preparation:

[0025] (1) Put chitosan in a reaction kettle according to the above mass parts, and melt it at 180°C, then add zinc acetate, glutaraldehyde, polyhydroxybutyrate, calcium hydroxyphosphate, sulfonated castor oil, polyethylene glycol Lactide and itaconic anhydride were stirred evenly at 130°C to obtain a mixture, wherein the stirring rate was 1200r / min;

[0026] (2) Send the mixture obtained in step (1) into a twin-screw extruder for granulation, cool, dry, and cut to obtain masterbatches. The temperature of the twin-screw extruder is 240°C, and the screw speed is 1200r / min ;

[0027] (3) Heat the masterbatch obtained in step (2) ...

Embodiment 3

[0029] A high-strength absorbable suture, consisting of the following components by mass: 42 parts of chitosan, 9 parts of zinc acetate, 4 parts of glutaraldehyde, 15 parts of polyhydroxybutyrate, 3 parts of calcium hydroxyphosphate, 15 parts of sulfonated castor oil, 11 parts of polyglycolide, 2 parts of itaconic anhydride.

[0030] Preparation:

[0031] (1) Put chitosan in a reaction kettle according to the above mass parts, and melt it at 160°C, then add zinc acetate, glutaraldehyde, polyhydroxybutyrate, calcium hydroxyphosphate, sulfonated castor oil, polyethylene glycol Lactide and itaconic anhydride were stirred evenly at 110°C to obtain a mixture, wherein the stirring rate was 900r / min;

[0032] (2) Send the mixture obtained in step (1) into a twin-screw extruder for granulation, cool, dry, and cut to obtain masterbatches. The temperature of the twin-screw extruder is 210°C, and the screw speed is 950r / min ;

[0033] (3) Heat the masterbatch obtained in step (2) to 1...

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Abstract

The invention discloses a high-strength absorbable suture and a preparation method thereof. The suture is composed of the following components in parts by mass: 39-51 parts of chitosan, 7-16 parts of zinc acetate, 2-11 parts of glutaraldehyde, 11-26 parts of polyhydroxybutyrate, 2-8 parts of Ca5(OH)(PO4)3, 13-24 parts of sulfonated castor oil, 9-17 parts of polyglycolide acid, and 1-8 parts of itaconic anhydride. According to the prepared suture disclosed by the invention, tensile strength can be improved, elongation is increased, moreover, complete absorption is realized and the suture can be widely applied to clinical treatment.

Description

technical field [0001] The invention belongs to the field of medical sutures, in particular to a high-strength absorbable suture and a preparation method thereof. Background technique [0002] Surgical suture refers to the special thread used for ligation hemostasis, suture hemostasis and tissue suture in surgical operation or trauma treatment. It can generally be divided into two categories: absorbable thread and non-absorbable thread. According to the material and the degree of absorption, it is divided into: catgut, chemical synthetic thread (PGA), and pure natural collagen suture. [0003] Chitosan is an alkaline polysaccharide containing strong amino groups. The molecule contains hydroxyl groups and amino groups, so it has good hygroscopicity, moisture retention and thickening properties. Chitosan has good biodegradability and can be biodegraded by chitosanase, lysozyme, etc., and the final product of enzymolysis is glucosamine, which has no side effects on the human b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L17/10A61L17/00
Inventor 吕少波李卓才李苏杨
Owner 温州嘉钮知识产权代理服务有限公司
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