Absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate)

A technology of mass percentage content and monofilament fiber, which is applied in the direction of filament/thread forming, conjugated synthetic polymer artificial filament, single-component copolyester artificial filament, etc., which can solve problems such as shortage and achieve material Complementary properties, high mechanical strength, and slow degradation time

Inactive Publication Date: 2014-03-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

PHBV and PHBHHx, that is, medium-chain PHA, have high mechanical strength, but are slightly insufficient in flexibility and degradability. Especially, PHBHHx contains more 3-HHx and has a ...

Method used

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  • Absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate)
  • Absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate)
  • Absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1, PHBHHx monofilament fiber

[0052] PHBHHx (weight-average molecular weight 230000, number-average molecular weight 125000, polydispersity coefficient 1.8, 3-hydroxycaproic acid content 12%) was added to the extruder of laboratory model (Ruojiang Chemical Fiber Company, Beijing, China) Press, extrude at 130°C in a spinneret hole with an inner diameter of 1 mm, wind up at a speed of 100 cm / min and quench in ice water at 0°C to obtain non-crystalline primary spinning. The extrusion speed is 60cm / min. Isothermal crystallization in ice bath for 3h and post-stretching. Under tension-maintaining conditions, anneal at room temperature for one day. The stretching speed is 10 m / min, and the diameter of the stretched monofilament fiber is 60 μm to 500 μm.

[0053] The performance of the monofilament fiber prepared in this embodiment is tested below.

[0054] (1) The scanning electron micrographs of the monofilaments with a diameter of 200-300 μm prepared in this ...

Embodiment 2

[0063] Embodiment 2, PHBHHx / PLA monofilament fiber

[0064] 10wt% PHBHHx (weight average molecular weight 230000, number average molecular weight 125000, polydispersity coefficient 1.8, 3-hydroxyhexanoic acid mass percentage content 12%) and 90wt% PLA (molecular weight 120000, where L- The mass percentage of isomers is 48%), melted and granulated, put into the extruder at 130°C, extruded in the spinneret hole with an inner diameter of 1mm, wound at a speed of 40-50cm / min and quenched in water at 0°C Cold, to obtain non-crystalline primary spinning. The extrusion speed is 60cm / min. Isothermal crystallization in ice bath for 5h and post-stretching. Under tension-maintaining conditions, anneal at room temperature for one day. The stretching speed is 12 m / min, and the fiber diameter after stretching is 50 μm to 300 μm.

[0065] The performance of the monofilament fiber prepared in this embodiment is tested below.

[0066] (1) The scanning electron micrographs of the PHBHHx / PL...

Embodiment 3

[0072] Embodiment 3, PHBV / PLA bundle fiber

[0073] Take 10-30wt% PHBV (molecular weight 500000, wherein the mass percentage of 3-hydroxyvaleric acid ester is 12%) and 70-90wt% PLA (molecular weight is 120000, wherein the mass percentage content of L-optical isomer is 48%) mixed in a high-speed mixer, poured into a twin-rod extruder to melt, extruded through 24-hole or 72-hole spinneret holes, the extrusion speed is 1000m / min, and then drawn twice under the condition of 65°C After heat setting, the obtained fiber diameter is 12-16 μm.

[0074] The properties of the bundled fibers prepared in this example are tested below.

[0075] (1) The scanning electron microscope photos of PHBV / PLA bundled fibers (2 / 8, m / m) with a single fiber diameter of 12-16 μm prepared in this example are as follows Figure 5 shown.

[0076] (2) The mechanical properties of the PHBV / PLA bundled fibers prepared in this example are shown in Table 3.

[0077] Table 3 Mechanical properties of each fibe...

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Abstract

The invention discloses an absorbable suture containing medium-chain PHA (Polyhydroxyalkanoate) (PHBV (Polyhydroxylbutyrate Valerate) or PHBHHx (poly (3-hydroxybutyrate-co-3-hydroxyhexanoate))). The invention specifically discloses a PHBHHx monofilament fiber, a PHBHHx/PLA (Poly Lactic Acid) monofilament fiber and a PHBV/PLA bunched fiber and preparation methods thereof. Blending with the PLA is performed, so that a spinning process is simple, complementary material performance is achieved, and the PHBHHx and the PHBV fibers are good in handfeel. Compared with the conventional material, the absorbable suture has the advantage of higher biocompatibility in the field of nerve and vascular repair due to the use of the PHA material. Moreover, the PHA is high in mechanical strength and slow in degradation speed, so that the PHA is excellent in application effect on the suture repair of cartilages and bone tissues. On the aspect of novel minimally invasive surgical repair, the PHBHHx and the PHBV contain nontoxic and non-irritant degradation products with high compatibility, so that surgical scars can be effectively reduced, and the absorbable suture has an application prospect in esthetic restoration.

Description

technical field [0001] The invention relates to a bioabsorbable material, in particular to an absorbable suture thread containing medium-chain PHA. Background technique [0002] Surgical sutures are divided into absorbable sutures and non-absorbable sutures according to absorbability. Non-absorbable sutures offer good tensile strength, but are limited by the need for reoperation to remove surgical sutures after surgery. Absorbable sutures can be selected according to the surgical site, suturing requirements, healing speed, etc., and the sutures that match the degradation speed and strength will be degraded and absorbed after the operation is completed. [0003] The biggest limitation in the development of absorbable sutures lies in the following aspects: 1. It needs to ensure good biocompatibility and be non-toxic and harmless after degradation. 2. While providing good degradability, ensure sufficient mechanical strength. [0004] Polyhydroxyalkanoates (PHAs) are a class ...

Claims

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Application Information

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IPC IPC(8): D01F6/84D01F8/14D01D5/08D01D5/28A61L17/12A61L17/10
Inventor 何钰吴琼任梦达丁长坤
Owner TSINGHUA UNIV
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