23 results about "Gelatin matrix" patented technology

The invention relates to the field of gel matrices and scaffold development; in particular for use in the field of tissue engineering and regenerative medicine (TERM) and provides for a water insoluble, thermo- stable, crosslinked gelatin matrix. The fabricated matrices of the invention can be applied directly into or onto the defect and the regenerative processes are allowed to take place according to the natural healing steps.

The invention aims to disclose a preparation method of sprayable phase change hydrogel and application of the sprayable phase change hydrogel in the field of robot bionic skin. In order to solve the problems that existing hydrogel is insufficient in mechanical property, low in transformation temperature, high in interface impedance, limited in industrial large-scale spraying and the like, a non-covalent cross-linking enhancement strategy is provided by introducing two-dimensional Ti3C2Tx MXene nanosheets into a gelatin matrix. MXene and gelatin synergistically stabilize a triple helix biological molecular structure through hydrogen bonds, ionic bonds and electrostatic interaction, so that the phase transition temperature of the composite hydrogel (GM hydrogel) is increased from 35 DEG C to 44 DEG C, and the mechanical strength of the composite hydrogel is remarkably improved. The hydrogel has solution sprayability and in-situ gelation characteristics, can form a super-conformal seamless interface with the skin / robot surface, can be widely applied to electronic skin, human-computer interaction interfaces and medical monitoring equipment, and provides a new way for industrial scale manufacturing of flexible bionic sensors.

The invention provides a taste-improved donkey-hide gelatin, walnut and sesame soft cake and a preparation method thereof. The taste-improved donkey-hide gelatin, walnut and sesame soft cake is mainly prepared from the following raw materials in parts by weight: 1-10 parts of donkey-hide gelatin, 1-10 parts of cowhide-derived edible gelatin, 10-30 parts of black sesame, 10-20 parts of walnut, 5-20 parts of yellow wine, 5-20 parts of rock candy and 1-10 parts of maltodextrin. The core process of the invention is as follows: cowhide-derived edible gelatin and yellow wine are subjected to hydrolysis treatment at a specific temperature, so that molecular weight distribution and gel characteristics of the cowhide-derived edible gelatin are optimized; the modified gelatin can effectively cooperate with the donkey-hide gelatin matrix and other raw materials to jointly construct an ideal gel network. The prepared soft cake product is soft and moderate in texture and fresh and cool in chewing, the texture and the taste are fundamentally improved, the defects that a traditional donkey-hide gelatin walnut sesame cake is hard in texture and prone to sticking to teeth are effectively overcome, and the eating experience and the product acceptability are remarkably improved.

A pharmaceutical composition comprising: an active pharmaceutical ingredient (API); 1-45 wt% non-gelatin matrix former comprising hydroxypropyl methylcellulose (hypromellose, HPMC), methyl cellulose,

The invention discloses a multifunctional efficient hemostatic sponge and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The hemostatic sponge is prepared by compounding magnesium aluminum silicate loaded with a polyphenol compound with a gelatin matrix, crosslinking and freeze-drying. The polyphenol compound is selected from one or more of tannic acid, gallic acid, EGCG (epigallocatechin gallate) and quercetin. The preparation method comprises the following steps: dispersing magnesium aluminum silicate into colloid; loading a polyphenol compound on the magnesium aluminum silicate to obtain a composite material; uniformly dispersing the composite material in a gelatin solution, and adding a cross-linking agent for cross-linking; and finally, freeze-drying and forming. Synergistic interaction is achieved through the rapid water absorption and coagulation promoting characteristics of the magnesium aluminum silicate, the physical support effect of the gelatin and the long-acting antibacterial and anti-inflammatory functions of the polyphenol compound, and the obtained sponge has a porous structure, excellent hemostatic performance, lasting antibacterial activity, good biocompatibility and degradability, and can be used for preparing the medical hemostatic sponge. The device is suitable for surgical operation, wound first aid and infected wound surface treatment.

A nutritional composition for administering to a human includes an amount of bioavailable protein that is safe for human consumption and that is effective for supporting the synthesis of proteins, and the repair and maintenance of cells and tissues throughout the body. An amount of a medium-chain triglyceride that is safe for human consumption and that is effective for maintaining gut health, an amount of an emulsifier that is safe for human consumption and that is effective for maintaining cellular health, and an amount of soluble fiber that is safe for human consumption and that is effective for maintaining or enhancing a health of the gut or cardiovascular system are also included. An amount of one or more vitamins and minerals that are effective for blood cell production are also included. The nutritional composition is formed as a chewable dosage form comprising a gelatin matrix.

The present application relates to an organic selenium nutrient solution for crops and a preparation method thereof. The nutrient solution comprises, by mass percentage, selenomethionine 0.1-0.5%, complex amino acids 2.0-5.0%, potassium humate 1.0-3.0%, plant extracts 0.5-1.0%, EDTA chelated calcium, magnesium and zinc 0.05-0.5%, potassium sorbate 0.05-0.2%, and purified water as the remainder. Preferably, the selenomethionine is L-type selenomethionine with a three-layer coating, the inner layer of which is formed by cross-linking chitosan and citric acid, the middle layer is hydroxypropyl methyl cellulose, and the outer layer is a sodium alginate-gelatin matrix cross-linked by Ca 2+ / Zn 2+ complex ions. The preparation method comprises adding and chelating each component under specific pH conditions, and stabilizing to form a stable multi-component synergistic system. The nutrient solution has the advantages of high bioavailability, good controlled release performance, high plant absorption efficiency, and strong component stability.

Disclosed is a confectionery product containing sugar and a gelatin base, able to withstand high temperatures and improper sale conditions, such as exposure to particularly high temperatures without adequate protection.

The present disclosure is directed to pharmaceutical compositions using non-animal-based matrix formers and method of making such pharmaceutical compositions. The pharmaceutical compositions can include an active pharmaceutical ingredient, a non-gelatin matrix former, and a structure former. Such a composition offers comparable and / or improved characteristics compared to gelatin pharmaceutical compositions.

A hydrogel for cell-laden bioprinting, bioink, and a preparation method and an application thereof, relates to the technical field of biomedical polymer hydrogels. The hydrogel for cell-laden bioprinting is polymer gel formed by adding a cell-specific material into a matrix of alginate and gelatin and crosslinking and curing, wherein the cell-specific material is polypeptide selected according to different laden cells. The structures printed using the hydrogel may have the advantages such as adjustable mechanical properties, adjustable porosity, high biocompatibility, high printing accuracy, and high customizability, which may widely support the printing of human tissues and organs such as spinal cord, cartilage, and heart, and has good prospects for applications in tissue repair, organ transplantation and so on.

The invention discloses a nano iron oxide and colla corii asini synergistic blood replenishing nutrition formula and a preparation method thereof. The formula comprises the following components: 0.5-3% of surface functionalized nano iron oxide, 0.5-3% of colla corii asini and the balance of water. 30-50% of a donkey-hide gelatin matrix; 0.5 to 2.5% of vitamin C or a vitamin C derivative; 2-7% of plant polysaccharide; 0.5-3% of a licorice extract; 40-55% of ice syrup; the preparation method comprises the following steps: dissolving the donkey-hide gelatin matrix, adding the premixed nano iron oxide and vitamin C derivative, carrying out ultrasonic dispersion, sequentially adding other components, and carrying out homogenization treatment. According to the invention, sodium citrate or gelatin-coated nano iron oxide is used as a high-efficiency iron source and is matched with the blood replenishing effect of donkey-hide gelatin to realize function synergy; the bioavailability of iron is remarkably improved through the compatibility of vitamin C and polysaccharide; the nutritional powder has the advantages of traditional nourishing and modern nutritional supplement, and can be prepared into various dosage forms such as paste and soft sweets. In addition, the in-vitro absorption rate is 1.8-2.5 times of that of a traditional iron agent, the gastrointestinal irritation is remarkably reduced, and the iron-containing compound preparation is particularly suitable for nutrition intervention of people suffering from iron-deficiency anemia.

This invention relates to the field of food packaging materials technology, and discloses an edible antibacterial packaging film containing tilapia skin gelatin hydrolysate peptides, comprising the following components: tilapia skin gelatin: 55-65%; antibacterial peptides: 18-22%, wherein the molecular weight of the antibacterial peptides is less than 5 kDa, prepared by microwave-ultrasound synergistic directional enzymatic hydrolysis of gelatin; tea polyphenols: 0.8-1.2%; nanocellulose: 0.8-1.2%; citric acid: 0.8-1.2%; the balance being deionized water; in the preparation of the antibacterial peptides: the microwave parameters are 2.45 GHz, 300-500 W, pulse mode on for 25-35 seconds / off for 8-12 seconds; the ultrasonic parameters are 18-22 kHz, 180-220 W, and are synchronously turned on with the microwave pulse; the tea polyphenols and nanocellulose form a composite reinforcing agent through pre-adsorption and covalent cross-linking. By modifying the interface between tea polyphenols and nanocellulose, a uniformly dispersed composite reinforcing network is formed, which effectively enhances the mechanical strength and deformation resistance of the gelatin matrix, while reducing water vapor permeability, making the material more suitable for food packaging needs in high humidity environments.

The present disclosure is directed to pharmaceutical compositions using non-animal-based matrix formers and method of making such pharmaceutical compositions. The pharmaceutical compositions can include an active pharmaceutical ingredient, a non-gelatin matrix former, and a structure former. Such a composition can offer comparable and / or improved characteristics compared to other gelatin pharmaceutical compositions.

The application discloses a gelatin matrix radionuclide carrier, a gelatin matrix radionuclide product, a composition, a preparation method and application. The gelatin matrix radionuclide carrier is prepared from raw materials including modified gelatin and modified chelate; wherein the modified gelatin is selected from one or both of methacrylated gelatin and acrylated gelatin; the modified chelate is obtained by modifying a chelating agent through N-hydroxysuccinimide; the chelating agent is selected from one or more of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-triazacyclododecane-1,4,7-triacetic acid, ethylenediaminetetraacetic acid and diethylenetriaminepentaacetic acid; and the mass ratio of the modified gelatin to the modified chelate is 1g:(10-200)mg. The gelatin matrix radionuclide carrier can load metal radionuclides and non-metal radionuclides, and the obtained gelatin matrix radionuclide product after loading radionuclides can be injected. The application belongs to the field of biological medicine.

The invention relates to the technical field of aerogel, in particular to aerogel modified based on polyphenol modified HA nanorods as well as a preparation method and application of the aerogel. The aerogel modified based on the polyphenol modified HA nanorod is prepared from the following raw materials: a hydroxyapatite nanorod, polyphenol, gelatin, metal salt and an auxiliary agent, the mass ratio of the polyphenol to the HA nanorod is (0.2-0.8): 1; the mass ratio of the polyphenol modified HA nanorod to the metal salt to the gelatin is (0.5-2): (0.1-0.3): 1. The aerogel modified based on the polyphenol-modified HA nanorod provided by the invention exerts double flame-retardant effects in a combustion process: on one hand, phenolic hydroxyl groups of polyphenol catalyze a gelatin matrix to quickly form carbon at high temperature, a continuous and compact carbon layer is formed, and heat radiation and oxygen transfer are effectively blocked; on the other hand, thermal decomposition of the organic matrix material is further inhibited through the high thermal stability effect of the HA nanorod, and after the aerogel is combusted, the volume is kept stable, and no molten drops are generated.

The invention discloses a magnesium-loaded decellularized amnion microneedle and a preparation method thereof.The magnesium-loaded decellularized amnion microneedle comprises a needle tip part and a needle bottom part, and the needle tip part and the needle bottom part each comprise a photo-crosslinking gelatin matrix; the needle tip part further comprises magnesium ions; the needle bottom part further comprises decellularized amnion particles; the substitution degree of the methacrylated gelatin of the needle tip part is higher than that of the methacrylated gelatin of the needle bottom part. Through the puncture effect of the microneedle, magnesium ions for promoting angiogenesis are accurately delivered to the deep part of a wound surface, and meanwhile, decellularized amnion particles are slowly released by the needle bottom part so as to provide a long-acting regeneration microenvironment, so that functional synergy of vascularization promotion and tissue regeneration is realized. The microneedle can significantly enhance the vascularization level of the wound surface, effectively accelerate the healing process of the chronic refractory wound surface, and improve the repair quality.

The invention relates to an organic selenium nutrient solution for crops and a preparation method thereof. The nutrient solution is prepared from the following components in percentage by mass: 0.1 to 0.5 percent of selenomethionine, 2.0 to 5.0 percent of compound amino acid, 1.0 to 3.0 percent of potassium humate, 0.5 to 1.0 percent of plant extract, 0.05 to 0.5 percent of EDTA (Ethylene Diamine Tetraacetic Acid) chelated calcium, magnesium and zinc, 0.05 to 0.2 percent of potassium sorbate and the balance of purified water. Preferably, the selenomethionine is three-layer coated L-type selenomethionine, the inner layer of the selenomethionine is formed by crosslinking chitosan and citric acid, the middle layer of the selenomethionine is hydroxypropyl methyl cellulose, and the outer layer of the selenomethionine is formed by crosslinking a sodium alginate-gelatin matrix through Ca < 2 + > / Zn < 2 + > composite ions. The preparation method comprises the following steps: sequentially adding the components under a specific pH condition, chelating and stabilizing to form a multi-component synergistic stable system. The nutrient solution has the advantages of high bioavailability, good controlled release performance, high plant absorption efficiency and strong component stability.

The invention belongs to the technical field of deep eutectic gel materials, and particularly relates to a preparation method and application of sodium caseinate-carboxylated carbon nanotube-gallium-indium alloy compounded tough gelatin-based deep eutectic gel. Sodium caseinate, carboxylated carbon nanotubes and gallium-indium alloy are used as raw materials, a sea urchin-shaped coating structure is formed through self-assembly, and the sea urchin-shaped coating structure and a gelatin matrix are compounded to construct three-dimensional network hydrogel; and further dipping the gelatin-based eutectic gel in a choline chloride-based deep eutectic solvent system, and carrying out solvent replacement and microstructure regulation and control to prepare the high-toughness gelatin-based eutectic gel. According to the gel, through the stress dispersion effect of a sea urchin-shaped structure and the synergistic effect of DES, the characteristics of softness and weakness of traditional gelatin-based hydrogel are abandoned, and excellent mechanical properties are obtained. Benefited from the conductive network and ion transmission characteristics, the obtained gel can be applied to a flexible strain sensor, and a new thought is provided for the design of a high-toughness bio-based gel material.

Provided are fluorescent nanoparticle and related methods of using the fluorescent nanoparticles for imaging tumors. The fluorescent nanoparticle comprises a gelatin matrix; and a fluorophore encapsulated within the gelatin matrix and ionically-bound to the gelatin matrix. The encapsulated fluorophore has an encapsulation concentration selected to provide: quenching of fluorophore encapsulated within the gelatin matrix and a substantial fluorescence for the fluorophore released from the gelatin matrix.

The invention discloses a gelatin matrix nuclide carrier, a gelatin matrix loaded nuclide product, a composition, a preparation method and application. The gelatin matrix nuclide carrier is prepared from raw materials including modified gelatin and a modified chelate, wherein the modified gelatin is selected from one or two of methacrylated gelatin and acrylated gelatin; the modified chelate is obtained by modifying a chelating agent with N-hydroxysuccinimide; the chelating agent is selected from one or more of 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid, 1, 4, 7-triazacyclododecane-1, 4, 7, 10-tetraacetic acid, 1, 4, 7-triazacyclododecane-1, 4, 7-triacetic acid, ethylenediamine tetraacetic acid and diethylenetriamine pentaacetic acid; the mass ratio of the modified gelatin to the modified chelate is 1g: (10-200) mg. The gelatin matrix nuclide carrier can load both metal nuclide and non-metal nuclide, and a gelatin matrix nuclide-loaded product obtained after nuclide loading can be injected. The invention belongs to the field of biological medicine.

A biodegradable gelatin-based antioxidant film composition comprising: a) Gelatin as polymer matrix, b) a β-AKBA analogue incorporated into the matrix to improve the antioxidant properties, c) a plasticizer to improve the flexibility of the film and d) optional excipients to modulate the optical, mechanical and hydrophobic properties, wherein the β-AKBA analogue is dispersed in the gelatin matrix to achieve improved antioxidant activity and modified physical properties.

The invention belongs to the technical field of biodegradable materials, and particularly relates to a bridged ring type monoterpene essential oil modified gelatin matrix and a preparation method and application thereof.The bridged ring type monoterpene essential oil modified gelatin matrix is prepared from, by mass, 30%-40% of gelatin, 5%-15% of glutinous rice starch, 1%-3% of nano calcium carbonate, 1.5%-3.0% of bridged ring type monoterpene essential oil, 1%-10% of palm oil, 1%-20% of glycerin, 0.1%-1.0% of surfactant, 1%-10% of sorbitol and the balance water. And the balance of water. The bridged ring monoterpene essential oil modified gelatin matrix has bacteriostatic, antioxidant and hydrophobic functions, can be formed by punching, is suitable for contact with high-oil and high-fat products and easily-deteriorated products, and provides a multifunctional gelatin-based material solution for replacing traditional plastics.

The invention discloses carbon nano-based edible fruit fresh-keeping hydrogel and a preparation method and application thereof.The method comprises the following steps that S1, 5-fluorouracil and D-arginine are dissolved in deionized water, and carbon dots are prepared through a hydrothermal reaction; and S2, adding the carbon dots into the gelatin solution, and uniformly stirring to obtain the carbon nano-based edible fruit fresh-keeping hydrogel. The invention provides an edible fruit fresh-keeping hydrogel (CDs / Gel) based on carbon dots, and the carbon dots are synthesized by using gallic acid (GA), 5-fluorouracil (5-FU) and D-arginine (D-Arg) as precursors through a hydrothermal method; wherein the GA provides antioxidant activity, the 5-FU enhances the penetrating power of a bacterial membrane, and the D-Arg promotes an antibacterial effect; in combination with the excellent performance of the gelatin matrix, the shelf life of the fruits can be effectively prolonged by the CDs / Gel hydrogel; according to the invention, a safe and efficient solution can be provided for fresh-keeping of fruits and vegetables.