11 results about "Hydrodynamic radius" patented technology

A centrifugal microfluidic technique for heat treating emulsion-divided independent reaction volumes (IRVs) within a centrifugal microfluidic chip, and displacing the emulsion into a monolayer presentation chamber (pc) for imaging. A deep treatment chamber (tc) is provided for the heat treatment, a nozzle having a hydrodynamic radius for forming the IRVs is provided for injecting a sample for the IRVs into the tc filled with a dense immiscible medium. The tc is adjacent a heat controlled element for collectively heat treating the IRVs within the tc, where the IRVs form a 3d packing arrangement. The tc is coupled to a presentation chamber (pc) by an opening through which the IRVs can be selectively displaced without collapsing. The pc is adjacent a window transparent to a wavelength for inspecting the pc.

The present application relates to a kind of three types of oil layer classification well concentration design method based on system hydrodynamics radius. Mainly solve the existing method when the concentration design of single well only gives the lower limit value of concentration without reasonable upper limit value, for the injection concentration of three types of oil layer with smaller pore throat radius is too high, which can lead to injection difficulty even plugging oil layer problem. Including the following steps: 1, obtain classification well K80;2, calculate the pore throat radius corresponding to K80;3, through the ratio of pore throat radius / hydrodynamics radius and flow state, the different hydrodynamics radius limit value corresponding to classification well K80 is determined;4, test the water dynamic radius of injection system under different concentration conditions;5, determine the concentration range suitable for classification well;6, determine the average concentration design standard of classification well according to the formation coefficient of classification well;7, determine the injection concentration of single well. The method can ensure the stable injection of polymer at the initial stage of injection, and ensure that the concentration design of different types of well group is more reasonable.

A method for determining binding parameters between a first particle (L) and a second particle (A) capable of non-covalently interacting with the first particle. The method includes acquiring N sets of raw data, each set of raw data acquired by performing a Taylor dispersion determination, and processing each of at least one set of raw data. Each Taylor dispersion determination for acquiring the corresponding set of raw data includes i) supplying a liquid portion comprising a sample portion containing the second particle (A) and at least one supplementary portion into a microfluidic channel, such that the sample portion and at least one supplementary portion form an interfacial contact in the microfluidic channel, wherein at least one of the liquid portions comprises a certain concentration of the first particle (L); ii) supplying the liquid portion to a flow in the microfluidic channel; and iii) acquiring the set of raw data, which includes reading a marked signal intensity s(t) as a function of time. Each set of raw data includes at least one imbalance readout, and processing each of the N sets of raw data includes determining the apparent diffusivity D and the hydrodynamic radius R. h At least one of them, and thus determine and will be the fitting equation for each of the N sets of original data.

The application relates to the field of material analysis, and discloses a test method for analyzing the properties of lotus plumule extract, which comprises the following steps: introducing the lotus plumule extract to be detected into a flow detection pool to establish a transient electrically induced birefringence monitoring field; applying a high-frequency bipolar symmetric square wave electric field to an excitation electrode pair; using the polarity high-frequency switching characteristic to limit the displacement of free ions within a local perturbation range, and simultaneously inducing the electric dipole orientation arrangement of alkaloid molecules; removing the electric field; monitoring and recording the transient birefringence decay trajectory data; and processing the data to separate the spin relaxation time constants belonging to different components, and determining the contents of nuciferine, isonor-lausplumuline and methylnuciferine according to the mapping rule between the constants and the effective hydrodynamic radius of molecules. The application realizes the physical decoupling of overlapping signals in the time domain through the spin relaxation characteristic, effectively suppresses the ionization interference of a complex matrix, and ensures the stability of a detection baseline.

The application discloses an anti-tumor immunotherapy nanoparticle and a preparation method and application thereof, relates to the technical field of nano-preparations, and has the technical scheme as follows: a core-shell structure includes two parts of a core and a shell; the core is a manganese oxide nanoparticle; the shell is a high-molecular polymer carrying a sound-sensitive agent; the hydrodynamic radius of the manganese oxide nanoparticle is 179.0+ / -10.8 nm, and the surface potential is 9.45+ / -1.73 mV; and the manganese oxide adjuvant is further included, wherein the manganese oxide adjuvant is a manganese dioxide nanoparticle, the sound-sensitive agent is one of porphyrin and derivatives thereof; the high-molecular polymer is a polylactic acid-glycolic acid copolymer; the particle size of the manganese dioxide nanoparticle is 20.7+ / -2.5 nm, and the surface potential is 17.34+ / -0.66 mV; and the effect is to provide a simple and effective strategy for the individualized immunotherapy of tumors.

The preparation process comprises the following steps: S1, adding amino-terminated hyperbranched polyamide-amine (the branching degree is 0.5-0.68, the hydrodynamic radius is less than 3 nm, and the number of amino-terminated groups is 3-8) and a catalyst into a polyamide acid solution, stirring and reacting under the protection of an inert atmosphere, filtering, washing, and drying to obtain the colorless transparent high-performance polyimide film. A pre-crosslinked polyamide acid solution is obtained; and S2, uniformly coating the pre-crosslinked polyamide acid solution on a substrate, carrying out thermal imidization reaction under the protection of inert atmosphere, and stripping the film from the substrate to obtain the colorless transparent high-performance polyimide film. The method is simple in process, mild in condition, good in compatibility with an existing production line, free of complex pretreatment, suitable for large-scale continuous production and remarkable in comprehensive cost advantage, provides an effective way for solving the problem that optical performance, heat resistance and mechanical performance of an existing polyimide film are difficult to consider into account, and has a wide application prospect in the field of flexible photoelectricity.

The invention relates to a branched water-soluble polymer with high critical solution temperature and a preparation method and application thereof, and the method takes electrostatic interaction between zwitterions as a theoretical basis, and is supplemented with a hydrophobic third monomer with a rigid structure; a plurality of free radicals are generated during initiation polymerization by utilizing dynamic balance of hydrogen bonds between hydrophilic and hydrophobic monomers and electrostatic interaction between zwitterionic monomers and simultaneously adopting a reducing agent, so that a polymer with a branched structure is obtained, and the polymer is converted into a three-dimensional network structure from a linear molecule; according to the present invention, the partial rigidity and the steric hindrance effect of the molecular chain are significantly enhanced, the chain segment movement under the high temperature condition is effectively inhibited, the compression effect of the salt ions on the polymer fluid mechanics radius is relieved, the resistance of the polymer to the high temperature and the salt is enhanced to a certain degree, and the good solubilizing effect on the aqueous solution is provided; the solubilizing agent is used for solubilizing salt aqueous solution and improving the density of saline water.

The invention discloses a rapid polymer injection performance evaluation method based on molecular linearity, which comprises the following steps: determining a molecular gyration radius Rg0 and a hydrodynamic radius Rh0 of a polymer molecular chain at an angle of 0, and quantitatively characterizing the linear degree of the polymer molecular chain by a ratio of Rg0 / Rh0; according to the method, the injection performance of polymers with similar molecular weights and the same concentration is quickly evaluated by utilizing a rule that the higher the Rg0 / Rh0 ratio is, the higher the linear degree of molecular chains is and the better the injection performance of the polymers in polymer solutions with similar molecular weights and the same concentration under a certain mineralization degree condition; by adopting the technical scheme provided by the invention to evaluate the injection performance of the polymer, the evaluation result is accurate and reliable, the experiment time consumption is greatly reduced, and the working efficiency is greatly improved.

The invention relates to a composition for preparing a confining liquid, the confining liquid and an application of the confining liquid in immunodetection. Comprising the following components in parts by mass: 1-1.5 parts of a buffering agent, 1-4 parts of a protein protective agent, 0.5-1 part of a metalloproteinase activity inhibitor, 0.1-2 parts of a polypeptide sealing agent, 0.5-2 parts of a first surfactant, 0.01-0.12 part of a second surfactant and 0.005-0.3 part of a bacteriostatic agent. When the first surfactant and the second surfactant are dissolved in the same solution, the hydrodynamic radius of the first surfactant is larger than that of the second surfactant. The sealing device has the beneficial effects that the sealing effect is good, the incubation time of sealing liquid in immunodetection can be shortened, and the detection efficiency is effectively improved.

A microfluidic cartridge and associated apparatus for performing exchange of buffers or concentrating biologics in liquid are disclosed. The cartridge may include a liquid transport mechanism, a sample container, a series of concentration measurement chambers, and air pressure driven valves for flow control. The cartridge may have a port through which the sample is transported to viscosity, static light scattering, and / or dynamic light scattering measuring devices in sequence for measurement of interaction parameter, molecular weight, hydrodynamic radius, opalescence, viscosity, and / or osmolality.

The invention discloses a special high-temperature-resistant antistatic oil agent for polyphenylene sulfide spinning as well as a preparation method and application thereof, and belongs to the technical field of chemical fiber oil agents. The oiling agent comprises a cluster dispersion formed in situ; the dispersoid is prepared by shearing and dispersing nano metal conductive particles and high-molecular polymer microspheres in high-temperature-resistant base oil consisting of tetrameric ricinoleate and nonylphenol polyoxyethylene ether at the rotating speed of 200-400rpm for 30 minutes under the conditions that the temperature is 70-80 DEG C and the absolute pressure is less than or equal to 0.05 MPa. The average hydrodynamic radius of the cluster dispersoid is 80-120nm, and the particle size increase amplitude is less than or equal to 15% after the cluster dispersoid is kept at the constant temperature of 260 DEG C for 30 minutes, so that the cluster dispersoid shows excellent high-temperature stability. The preparation method disclosed by the invention comprises three steps of oil phase construction, cluster in-situ formation and emulsifying and sizing. The oiling agent is particularly suitable for a high-temperature and high-speed spinning process of polyphenylene sulfide fibers at the spinning temperature of more than 300 DEG C and the channel temperature of 220-260 DEG C, and can effectively solve the problems of antistatic failure and oiling agent decomposition at high temperature.