155 results about "Protein polymer" patented technology

Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and / or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also described are conjugates directed against human vascular endothelial growth factor (VEGF), human p185 receptor-like tyrosine kinase (HER2), human CD20, human CD18, human CD11a, human IgE, human apoptosis receptor-2 (Apo-2), human tumor necrosis factor-α (TNF-α), human tissue factor (TF), human α4β7 integrin, human GPIIb-IIIa integrin, human epidermal growth factor receptor (EGFR), human CD3, and human interleukin-2 receptor α-chain (TAC) for diagnostic and therapeutic applications.

An apparatus for introducing a curable biomaterial into a spinal disc nucleus pulposus, comprises: an injection needle sized for introduction into the nucleus pulposus; a syringe operable to inject a curable biomaterial contained in the syringe under fluid pressure through the injection needle; and a valve coupled between the injection needle and the syringe. The valve is operable in an open position to permit passage of the biomaterial from the syringe into the needle under fluid pressure, and in a closed position to maintain the fluid pressure of the injected biomaterial within the nucleus. In certain embodiments, the needle has a relatively smooth outer surface and a substantially constant outer diameter over its length. An outer docking cannula may also be provided that is sized and configured for piercing through the disc annulus and for docking thereto. A kit of parts is provided that comprises: a cannula having a distal end and a proximal end, the distal end of the cannula adapted to be inserted through the disc annulus; an injection needle having a distal end and a proximal end, the distal end adapted to be inserted into the proximal end of the cannula and configured for relatively close sliding fit therewithin; and a syringe for containing a quantity of curable biomaterial, the syringe adapted to be coupled to the proximal end of the needle and to inject the biomaterial into the needle under pressure. The kit may further comprises a quantity of curable biomaterial that is selected to have upon curing strong adhesive properties such as a protein polymer.

The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.

The present invention provides a protein polymer material and a method for preparing the protein polymer material involving applying an energy such as electrical energy or gravitational energy to a protein to cause the protein to assemble in a controlled arrangement. The protein used in this method may be any suitable fibrillar protein capable of self-assembling.

The present invention provides personal care compositions, and more particularly, personal care compositions comprising a bioactively effective amount of a repeat sequence protein polymer. In some particularly preferred embodiments, the present invention provides personal care compositions comprising an effective amount of at least one fragment of a repeat sequence protein polymer having bioactivity.

Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.

The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing free fatty acids (FFA), glycerides, or combination thereof as well as polysaccharides, cellulose, hemicellulose, lignocellulose, protein polymers, or combination thereof in presences of an alcohol and an acid catalyst.

The present invention relates to a method for producing fatty acid alkyl esters as well as cellulosic simplified sugars, shortened protein polymers, amino acids, or combination thereof resulting from the simultaneous esterification and hydrolysis, alcoholysis, or both of algae and other oil containing materials containing phospholipids, free fatty acids (FFA), glycerides, or combination thereof as well as polysaccharides, cellulose, hemicellulose, lignocellulose, protein polymers, or combination thereof in the presence of an alcohol and an optional acid catalyst.

Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and / or clearance rate in circulation as compared to the underivatized parental antibody fragment.

In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the synthetic proteins are elastin-mimetic proteins having improved mechanical characteristics and related methods of making the proteins with the capability of providing precise control over the mechanical properties. Provided are proteins used in a number of medical devices such as artificial blood vessels, shunts, stents or as embolic agents in situations where it is desired to stop or reduce blood flow or pressure in a localized region.

The present invention relates to methods for producing an aerated polymeric composition or aerated polymeric pet chew and the resultant product. The aerated pet chew includes a dry blend, a leavening agent, and a plasticizing slurry. The dry blend includes an amount of protein polymer.

Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and / or clearance rate in circulation as compared to the underivatized parental antibody fragment. Also described are conjugates directed against human vascular endothelial growth factor (VEGF), human p185 receptor-like tyrosine kinase (HER2), human CD20, human CD18, human CD11a, human IgE, human apoptosis receptor-2 (Apo-2), human tumor necrosis factor-α (TNF-α), human tissue factor (TF), human α4β7 integrin, human GPIIb-IIIa integrin, human epidermal growth factor receptor (EGFR), human CD3, and human interleukin-2 receptor α-chain (TAC) for diagnostic and therapeutic applications.

Tissue adhesives formed by crosslinking albumin and / or gelatin with certain polyamines and / or polycarboxylates using a water-soluble carbodiimide are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.

A biodegradable scale and corrosion inhibiting composition includes between about 50 and about 90% by weight of a protein polymer that is derived from a natural source, and between about 10 and about 20% by weight of the alkali salts of gluconic acid.

The present invention relates to an aerated polymeric composition. The composition includes a protein polymer and an agent or method for causing porosity in the finished aerated polymeric composition, such as a leavening agent. Additionally, the present invention relates to methods for forming the aerated polymeric composition, in particular, methods for forming aerated pet treats or chews.

A method of synthesizing a protein-polymer conjugate includes the steps: covalently attaching at least one controlled radical polymerization initiator to a protein to form a protein-initiator composition; and mixing the protein-initiator composition with at least one monomer which undergoes controlled radical polymerization in the presence of the protein-initiator composition under conditions suitable to initiate the controlled radical polymerization.

A personal care composition is provided and includes an effective amount of a repeat sequence protein polymer. The personal care composition may be a hair care composition, a skin care composition, a nail care composition, a cosmetic composition, or an over-the-counter pharmaceutical composition.

A method of producing polymers of an isolated spider silk protein involves providing a solution of said spider silk protein in a liquid medium at pH 6.4 or higher and / or an ion composition that prevents polymerisation of the spider silk protein. The properties of the liquid medium are adjusted to a pH of 6.3 or lower and an ion composition that allows polymerisation of the spider silk protein. The spider silk protein is allowed to form polymers in the liquid medium, and the resulting spider silk protein polymers are isolated from the liquid medium. The resulting polymers are useful as fibers, films, foams, nets or meshes.

A rack for holding and organizing hair extensions comprises a vertical stand upon which a cylindrical member is attached at the upper end. A plurality of rack arms radiate outwardly from the cylindrical member. Each rack harm comprises a plurality of parallel and spaced apart teeth, the teeth having a groove between them. The width of the groove is sized such that the individual strands of hair of the extension fit through the groove, but the protein polymer at the end of the extension is too large to fit through the groove, such that the extensions may be suspended from the rack arms. The rack arms may be angled to facilitate placing extensions within the grooves, and removing the extensions from the grooves.

Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesives and sealants. Particularly, block copolymers of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents.

The invention discloses a plasma resonance microstructure fiber sensor which comprises a light source, two ordinary single mode fibers, a microstructure fiber and a photoelectric detector, wherein, the light source, the first ordinary single mode fiber, the microstructure fiber, the second ordinary single mode fiber and the photoelectric detector are connected sequentially; the microstructure fiber is formed by photonic crystal fiber taper which has paralleled hexagon cross section and two-dimensional periodic structure; a metal membrane and a protein polymer membrane are coated on the surface of the tapered section from inside to outside sequentially; and the periodic structure consists of a background medium and dielectric rods which are distributed and arranged in the background medium periodically. As the usage of a microstructure fiber cladding light guiding mechanism, the fiber sensor can not only educe a guided mode without peeling cladding, but also realize high coupling efficiency of optical power of incident wave entering surface plasma resonance wave without a buffer layer. The invention has the advantages of simple process, compact structure, high measuring accuracy, strong anti-interference ability, being capable of being operated in harsh environment, and the like.

Methods for identifying and characterizing inhibitors of protein filament formation are provided. These methods are particularly useful for identifying those agents which inhibit or prevent protein filament formation within neurons of mammalian subjects, particularly human subjects, such as the formation of tau filaments in Alzheimer's patients, and α-synuclein filaments in Parkinson's patients. According to the methods, protein monomers which are associated with formation of intra- or extra-cellular aggregates are combined under physiological conditions with a fibrillization inducer and the formation of protein aggregates is assessed in the absence and the presence of a test agent. The absence or a reduction in the size or stability of proteinaceous polymeric filaments as compared to a control indicates that the test agent is an inhibitor of proteinaceous polymeric filament formation.

A rack for holding and organizing hair extensions comprises a vertical stand upon which a cylindrical member is attached at the upper end. A plurality of rack arms radiate outwardly from the cylindrical member. Each rack harm comprises a plurality of parallel and spaced apart teeth, the teeth having a groove between them. The width of the groove is sized such that the individual strands of hair of the extension fit through the groove, but the protein polymer at the end of the extension is too large to fit through the groove, such that the extensions may be suspended from the rack arms. The rack arms may be angled to facilitate placing extensions within the grooves, and removing the extensions from the grooves.

Systems are provided for the controlled release delivery of active agents through the use of repeat sequence protein polymers. The systems may exist as matrices, gels, hydrogels, films, emulsions or microparticles and are particularly useful for incorporating active agents into personal care product compositions.

The invention belongs to the detection field of biotechnology and particularly relates to a mycoplasma hyopneumoniae antibody detection kit and a manufacture method thereof. A solid carrier is wrapped by a link-coupled mycoplasma hyopneumoniae peculiar polypeptide antigen, and the manufactured mycoplasma hyopneumoniae peculiar polypeptide antigen enzyme-linked immuno sorbent assay (ELISA) detection kit is used for clinical detection of mycoplasma hyopneumoniae infection, epidemiological investigation and immunologic surveillance. The non-protein polymer directional link-coupled mycoplasma hyopneumoniae peculiar polypeptide antigen serves as the wrapping solution, the combination efficiency of polypeptide and a target antibody is effectively improved, accordingly, detection sensitivity is remarkably improved, non-singular background value reading is remarkably reduced simultaneously, the specificity is high, and the detection kit has the advantages of being easy to operate, fast in diagnosis, economic and convenient in large-scale detection and the like. The manufacture method is convenient to popularize and has wide application prospect. When the kit is used for detecting samples, the using amount of the wrapping antigen can be reduced to 10ng / ml, so that cost is reduced, and popularization and using are facilitated.

The invention discloses a protein-polymer composite nano-carrier and a preparation method thereof and relates to the field of nano preparations of antitumor medicines. The protein-polymer composite nano-carrier is designed and developed on the basis of the characteristics of a lipoprotein structure of a human body and comprises a polymer core and a hydrophilic protein shell; a targeting ligand can be flexibly modified according to the treatment requirement, so as to construct the protein-polymer composite nano-carrier with active targeting property; the in vivo stability of the medicine is improved; the tumor targeting property is increased. In order to increase the load rate of the protein on the polymer kernel, a cationic additive is added to the formula to prepare a cationic polymer nanoparticle; nano suspension is milk white liquid; spherical particles with relatively uniform distribution can be seen by scanning through a transmission electron microscope. A freeze-drying protective additive is added for freeze-drying the nano suspension to form powder, so that the protein-polymer composite nano-carrier is relatively easy to store and the stability is improved. The protein-polymer composite nano-carrier prepared by the method is uniform in particle size and good in stability; and a fat-soluble antitumor medicine can be effectively encapsulated.

Protein-polymer compositions and processes for their production are provided where the compositions have improved resistance to ultraviolet light induced weathering and associated loss of enzyme activity. The incorporation of both a sterically hindered amine and an ultraviolet light absorber at a concentration of at least 5% by weight produces a curable or cured composition with UV stabilized enzyme activity that can be used as a bioactive coating with improved stain removal properties.