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13 results about "Optical mapping" patented technology

Optical mapping is a technique for constructing ordered, genome-wide, high-resolution restriction maps from single, stained molecules of DNA, called "optical maps". By mapping the location of restriction enzyme sites along the unknown DNA of an organism, the spectrum of resulting DNA fragments collectively serves as a unique "fingerprint" or "barcode" for that sequence. Originally developed by Dr. David C. Schwartz and his lab at NYU in the 1990s this method has since been integral to the assembly process of many large-scale sequencing projects for both microbial and eukaryotic genomes. Later technologies use DNA melting, DNA competitive binding or enzymatic labelling in order to create the optical mappings.

Space intelligent non-planar reflection generation method based on surface normal guidance

The invention provides a space intelligent non-planar reflection generation method based on surface normal guidance. Extracting multi-layer visual representation from an original RGB image containing a non-planar reflection medium scene, and identifying a non-planar reflection area by combining brightness distribution of the original RGB image and a spatial symmetry relation; analyzing non-linear deformation features of textures in the non-planar reflection area, and predicting pixel-level three-dimensional surface normal vectors and confidence distribution in combination with multi-layer visual representation to construct a surface normal graph; determining a line-of-sight vector based on a camera imaging model, and executing geometrical optical mapping operation on the line-of-sight vector, the surface normal graph and the confidence distribution to construct a reflection offset field; extracting an intermediate semantic feature representation corresponding to the non-planar reflection region, and generating a pre-distortion reflection feature representation according to the reflection offset field and the intermediate semantic feature representation; and injecting the pre-distortion reflection feature representation, the multi-layer visual representation and the initial reflection area mask into a generative model for image reconstruction, and generating a non-planar reflection image.
Owner:BEIJING FEIDU TECH CO LTD

All-optical non-linear activation device, system and method

PendingUS20250068032A1Physical realisationNon-linear opticsOptical mappingNonlinear optical
Aspects of embodiments pertain to an optical mapping device having non-linear optical characteristics. The device may comprise an optical unit that is configured to direct an optical signal from an input interface to an output interface of the optical unit. The device includes a substance causing the optical unit to attain saturable absorber characteristics such that absorption of an optical input signal guided from the input interface to the output interface by the optical unit decreases with an increase in optical signal intensity received by the optical unit. In some examples, the saturable absorber characteristics of the mapping device are selectively adaptable.
Owner:BG NEGEV TECHNOLOGIES & APPLICATIONS LTD

Non-invasive analysis of electrophysiological processes using imaging and deep learning

PCT designated stage expiredWO2024233961A3SurgeryCatheterImaging heartRadiology
This invention provides new and useful methods for accurately imaging heart rhythm disorders. Novel panoramic optical mapping methods, and recent advances in machine learning techniques, are used to create a mechano-electrical model effective in predicting electrical activity of a tissue based on motion of the tissue. Deep learning techniques for constructing three-dimensional intramural electrical wave patterns from surface data, imaging chambers for performing panoramic optical mapping methods, and deep learning techniques for motion tracking tissue via optical and / or ultrasound data are also provided. The optical mapping and deep learning techniques of the disclosure may be applied in a plurality of different ways, individually or in combination, to improve the diagnosis and treatment of heart rhythm disorders. Also provided are systems for performing the methods described herein as well as non-transitory computer readable storage media and computer products.
Owner:RGT UNIV OF CALIFORNIA

High-precision optical surveying and mapping holder capable of preventing observation interference

PendingCN120333307ASurveying instrumentsUsing optical meansInterference phenomenonElectric machine
The invention discloses a high-precision optical surveying and mapping holder capable of preventing observation interference, which comprises a horizontally arranged connecting seat, the top of the connecting seat is rotatably connected with a base, and the base is provided with a double-shaft motor of which the center line is horizontally arranged along the left-right direction; the left end and the right end of a main shaft of the double-shaft motor are respectively connected with a prism installation support through an elastic coupler, and the rear side of the base is provided with an adjustable positioning frame used for positioning the prism installation supports. According to the invention, the principle is scientific, the structure is compact, the two elastic couplings, the prism mounting bracket and the total reflection prism assembly are simultaneously driven by the double-shaft motor to rotate, and the height of the prism in the total reflection prism assembly is further adjusted, so that the interference phenomenon is avoided when a plurality of measurement points on the same straight line are subjected to distance measurement, and the measurement accuracy is improved. And meanwhile, good stability is achieved at the high position and the low position.
Owner:HUANGHE S & T COLLEGE

Tumor ablation planning using interstitial optical mapping

Devices, systems, and methods to generate a plan for an interstitial laser ablation procedure are disclosed. The systems may be configured as an interstitial optical mapping system including a catheter, an emitter optical fiber, an imaging optical fiber, a light source, and a processing unit. The emitter optical fiber and the imaging optical fiber are used to interstitially image a fluorescent dye associated with a tumor, including the tumor margin, at discrete imaging positions along a length of the catheter. The processor calculates a location of the fluorescent dye at each discrete position and creates an optical map representing the tumor. The optical map is used to generate an interstitial laser ablation plan that includes laser fiber pull-back positions.
Owner:MEDTRONIC NAVIGATION INC

Photon temperature measurement method and system based on single microcavity double optical comb reading

PendingCN122505425AOptical mappingRadio frequency signal
This invention provides a photonic temperature measurement method and system based on single-microcavity dual-optical-comb readout, relating to the field of photonic sensing technology. The method includes: acquiring a dual-path soliton optical comb propagating in reverse within a single microcavity; inputting the combined beam of the dual-path soliton optical comb into a temperature sensing unit to acquire radio frequency (RF) signal data and corresponding standard temperature data of the temperature sensing unit at different temperatures; determining the center wavelength data of the resonant mode of the temperature sensing unit based on the RF signal data; linearly fitting the average value of the standard temperature data and the center wavelength data of the resonant mode to obtain the thermo-optical mapping relationship of the temperature sensing unit; the thermo-optical mapping relationship is used to measure the temperature of the object under test via optical signals. The photonic temperature measurement method and system based on single-microcavity dual-optical-comb readout provided by this invention establishes a stable quantitative mapping relationship between optical signal wavelength and temperature, achieving both a wide measurement range and high measurement speed in scenarios with rapid temperature changes.
Owner:NATIONAL INSTITUTE OF METROLOGY CHINA

Artificial intelligence trained with optical mapping to improve detection of cardiac arrhythmia sources

ActiveUS12676235B2Optical mappingCardiac arrhythmia
Disclosed are various embodiments of methods, components and systems configured to determine a location of a source of cardiac arrhythmia in a patient's heart. In some embodiments, to determine a source location, electrogram signals are acquired from a region of the patients' heart using a first set of electrodes; and then a pre-trained artificial intelligence (AI) model is applied to predict the location of the cardiac arrhythmia source by using the signals. Importantly, pre-training of the AI model comprises acquiring electrogram signals from explanted human hearts, the signals are generated by a second set of electrodes assembled into an electrode array that covers at least a part of the explanted human heart, and acquiring co-registered functional and / or structural imaging data in the part of the explanted human heart covered with the electrode array, wherein the functional and / or structural imaging data provide location of at least one source of cardiac arrhythmia.
Owner:AVTONOMNAYA NEKOMMERCHESKAYA OBRAZOVATELNAYA ORGANIZATSIYA VYSSHEGO OBRAZOVANIYA SKOLKOVSKIJ INST NAUKI I TEKHNOLOGIJ +1

Loading type double-spectrum hundred-million-pixel array calculation camera

PendingCN121334475ACamera body detailsOptical axisOptical mapping
The invention relates to the technical field of camera shooting, and discloses a loading type double-spectrum hundred-million-pixel array calculation camera, which is characterized in that a visible light module and an infrared module are constructed into a double-spectrum array structure, and the double-spectrum array structure is subjected to partition thermal control and asynchronous sampling; geometric consistency and registration stability between the double-spectrum arrays can be maintained under the long-time high-power operation condition, so that the temperature gradient between imaging modules is balanced, the overall thermal noise of the arrays is remarkably reduced, and the transition smoothness of the splicing boundary is improved. Besides, through prediction compensation and online feedback correction of an optical mapping model, the camera can still keep optical axis consistency and imaging precision of high-resolution output under the conditions of maneuvering carrier vibration, external environment temperature change and power consumption fluctuation, and the application requirements of all-weather, full-vision-field and high-stability monitoring are met.
Owner:SHENZHEN ZHUOHE TECH CO LTD

Method for optical DNA mapping based on scanning electron microscopy (SEM)

A method of optical DNA mapping based on scanning electron microscopy (SEM) is provided. The method of optical DNA mapping according to one aspect provides enhanced accessibility and user friendliness, excellent compatibility with chemically functionalized surfaces and microfluidic devices, and the ability to obtain high resolution DNA images without the use of metals, by utilizing SEM as a base platform, as well as to provide a high resolution DNA imaging system. Therefore, optical DNA mapping with improved resolution can be realized.
Owner:IND UNIV COOP FOUND SOGANG UNIV +1

Label-free optical mapping for large-area biomechanical dynamics of multicellular systems

PCT designated stage expiredWO2025038400A1Electrostatic separationPhase-affecting property measurementsBiomechanicsOptical mapping
A device for label-free optical mapping of biomechanical dynamics of cells is provided. The device includes an optically transparent elastic polymer membrane having a top surface and a bottom surface opposite the top surface wherein the elastic polymer membrane is disposed on an optically transparent rigid substrate. A plurality of diffractive elements are disposed on the elastic polymer membrane, each diffractive element having an opaque occluding element disposed on the top surface of the elastic polymer membrane and an opaque layer disposed on the bottom surface of the elastic polymer membrane, wherein the opaque layer has a hole the same shape as the occluding element. The occluding element is aligned with the hole so that light impinging on the diffractive element normal to the top surface of the elastic polymer membrane is substantially blocked by the occluding element from passing through the hole of the bottom opaque layer.
Owner:RGT UNIV OF CALIFORNIA

DNA-protein-polymer-metal cation complex, DNA imaging method using the same, and SEM-based DNA detection method

PendingUS20250290120A1Microbiological testing/measurementBiological material analysisDna imagingOptical mapping
Disclosed are a DNA-protein-polymer-metal cation complex, a DNA imaging method using the same, and a scanning electron microscopy (SEM)-based DNA detection method. The DNA-protein-polymer-metal cation complex disclosed herein enables real-time imaging of DNA molecules of various shapes and lengths with improved resolution by using SEM even at high magnifications, and improves DNA detection, thereby further enhancing DNA optical mapping.
Owner:SOGANG UNIV RES & BUSINESS DEV FOUND +1

Electro-optical mapping system and method for electronic intelligent model

The invention provides an electronic intelligent model-oriented electro-optical mapping system and method, and the system comprises a semantic feature extraction module which is used for carrying out the semantic feature coding of an input image, text or multi-modal data, and outputting a semantic feature representation representing the calculation capability of an electronic intelligent model; the optical parameter generation module is used for generating optical calculation parameters for driving the optical calculation module according to the semantic feature representation under the condition of introducing a physical constraint condition of the target optical calculation module; and the optical calculation module is used for executing optical calculation based on the optical calculation parameters so as to reproduce the corresponding calculation capability of the electronic intelligent model in a function or calculation behavior level and realize mapping of the electronic intelligent model to the optical calculation system. According to the application, the efficient mapping and reliable deployment of the electronic intelligent model to the optical computing system can be realized without directly mapping the complete digital weight of the electronic model.
Owner:SHANGHAI JIAOTONG UNIV

Optical surveying and mapping satellite constellation three-dimensional imaging simulation method

The invention relates to an optical surveying and mapping satellite constellation three-dimensional imaging simulation method. The method comprises the following steps: constructing a live-action three-dimensional model based on an aviation oblique photogrammetry technology and a three-dimensional illumination rendering mode; the method comprises the following steps: acquiring preset satellite imaging data, constructing an image space vector and an object space vector, converting the image space vector and the object space vector to a body coordinate system, and constructing an imaging geometric model considering a satellite platform error parameter, a satellite camera error parameter and an atmospheric error parameter; traversing all pixels of the imaging plane in the live-action three-dimensional model, substituting image space coordinates corresponding to the pixels into the imaging geometric model, and generating a simulation image; a simulation image is previewed and output in real time through an interface, and satellite auxiliary data is output according to the imaging geometric model during output. Compared with the prior art, the method has the advantages that simulation imaging of ground objects with vertical facades such as buildings and steep high mountains can be achieved, and application of three-dimensional modeling is met.
Owner:TONGJI UNIV