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Optical mapping is a technique for constructing ordered, genome-wide, high-resolution restriction maps from single, stained molecules of DNA, called "optical maps". By mapping the location of restriction enzyme sites along the unknown DNA of an organism, the spectrum of resulting DNA fragments collectively serves as a unique "fingerprint" or "barcode" for that sequence. Originally developed by Dr. David C. Schwartz and his lab at NYU in the 1990s this method has since been integral to the assembly process of many large-scale sequencing projects for both microbial and eukaryotic genomes. Later technologies use DNA melting, DNA competitive binding or enzymatic labelling in order to create the optical mappings.
Artificial intelligence trained with optical mapping to improve detection of cardiac arrhythmia sources
Disclosed are various embodiments of methods, components and systems configured to determine a location of a source of cardiac arrhythmia in a patient's heart. In some embodiments, to determine a source location, electrogram signals are acquired from a region of the patients' heart using a first set of electrodes; and then a pre-trained artificial intelligence (AI) model is applied to predict the location of the cardiac arrhythmia source by using the signals. Importantly, pre-training of the AI model comprises acquiring electrogram signals from explanted human hearts, the signals are generated by a second set of electrodes assembled into an electrode array that covers at least a part of the explanted human heart, and acquiring co-registered functional and / or structural imaging data in the part of the explanted human heart covered with the electrode array, wherein the functional and / or structural imaging data provide location of at least one source of cardiac arrhythmia.
Owner:AVTONOMNAYA NEKOMMERCHESKAYA OBRAZOVATELNAYA ORGANIZATSIYA VYSSHEGO OBRAZOVANIYA SKOLKOVSKIJ INST NAUKI I TEKHNOLOGIJ +1