32 results about "Optical mapping" patented technology

Optical mapping apparatus for imaging an object, comprising an optical coherence tomography (OCT) system including an OCT source, an OCT reference path leading from the OCT source to an OCT receiver, an OCT object path leading from the object to the OCT coupler, an OCT depth scanner adapted to alter at least one of the OCT reference path and the OCT receiver path. A confocal system is provided including a confocal optical receiver a confocal path leading from the object to the confocal optical receiver via a confocal input aperture. An adaptive optics (AO) system is provided to correct optical aberrations in the OCT object path and the confocal path.

OCT apparatus includes an interferometer, having an input beam splitter and a 50/50 output splitter. The splitting ratio of the input splitter may be optimized depending on the source power of light source and on the mismatch of the balanced receiver. The input splitter is a plate beam-splitter to minimize the stray reflected light in the interferometer and allow sequential operation of the apparatus in the OCT or in the confocal regime. The switching between the two regimes may be at will, or synchronous with the en-face scanning which results in quasi-simultaneous OCT/confocal imaging or in alternatives frames, confocal and OCT. By using polarization sensitive elements, two channels are provided in each regime, OCT and confocal. The two confocal polarization sensitive channels may allow adjustments of compensators prior to OCT measurements or OCT imaging.

A soil mapping system for collecting and mapping soil reflectance data in a field includes an implement having a furrow opener for creating a furrow and an optical module. The optical module is arranged to collect soil reflectance data at a predetermined depth within the furrow as the implement traverses a field. The optical module includes two monochromatic light sources, a window arranged to press against the soil, and a photodiode for receiving light reflected back from the soil through the window. The two light sources have different wavelengths and are modulated at different frequencies. The photodiode provides a modulated voltage output signal that contains reflectance data from both of the light sources. Additional measurement devices are carried by the implement for collecting additional soil property data, such as electrical conductivity, pH, and elevation, which can be used together with the optical data to determine variations in soil organic matter.

The invention discloses a method for identifying whether fingerprints are true or false based on an optical mapping system. According to the method, the optical mapping system is integrated in a fingerprint detection window. The method includes the following steps that firstly, a finger is placed on the fingerprint detection window, a back-scattered spectrum is collected by the optical mapping system, and a fingerprint image is collected by an image collecting system at the same time; secondly, if the collected image meets the fingerprint integrity requirement, collected spectral data are compared with finger spectral data in a database; thirdly, if it is determined that an object to be detected is a true finger through spectrum comparison, the fingerprint image is analyzed so as to complete identity identification, and otherwise identification fails. By acquiring back-scattered spectrum information of the object to be detected through the spectrum technology in the process of collecting surface image information of the fingerprints, a finger of an organism can be distinguished from a finger mould.

The invention discloses an anti-skid tripod for an optical mapping instrument. The anti-skid tripod comprises an instrument containing table, a containing table connecting piece and a main support; the instrument containing table is connected with the main support through the containing table connecting piece; three lateral supports are connected to the upper portion of the main support through connecting rods, and foot pads are arranged at the bottoms of the lateral supports; each foot pad comprises a foot pad body and a foot pad connecting piece, and a spherical chamber is arranged in each foot pad body; and a spherical connecting part matched with each spherical chamber is arranged at one end of the corresponding foot pad connecting piece, and the other end of each foot pad connecting piece is connected with the end, far away from the main support, of each lateral support. The anti-skid tripod is stable in performance, simple in structure and convenient and rapid to use; the problem that an existing tripod is likely to skid so that the instrument can be damaged is solved; and the falling risk of the mapping instrument is reduced.

Methods and computer program products for super-resolution mapping of nanoprobes having spectrally distinguishable coherent scattering properties. A sample containing a plurality of nanoprobes is illuminated with broadband light, and coherent scattering by the nanoprobes is detected. Scattered light is spectrally associated with respective nanoprobes, allowing a position associated with each nanoprobe to be mapped.

A method for single-molecule optical DNA profiling using an exceptionally dense, yet sequence-specific coverage of DNA with a fluorescent probe, using a DNA methyltransferase enzyme to direct the DNA labeling, followed by molecular combing of the DNA onto a polymer-coated surface and subsequent sub-diffraction limit localization of the fluorophores. The result is a ‘DNA fluorocode’; a simple description of the DNA sequence, with a maximum achievable resolution of less than 20 bases, which can be read and analyzed like a barcode. The method generates a fluorocode for genomic DNA from the lambda bacteriophage using a DNA methyltransferase to direct fluorescent labels to four-base sequences reading 5′-GCGC-3′. A consensus fluorocode is constructed that allows the study of the DNA sequence at the level of an individual labeling site and is generated from a handful of molecules and entirely independently of any reference sequence.

A soil mapping system for collecting and mapping soil reflectance data in a field includes an implement having a furrow opener for creating a furrow and an optical module. The optical module is arranged to collect soil reflectance data at a predetermined depth within the furrow as the implement traverses a field. The optical module includes two monochromatic light sources, a window arranged to press against the soil, and a photodiode for receiving light reflected back from the soil through the window. The two light sources have different wavelengths and are modulated at different frequencies. The photodiode provides a modulated voltage output signal that contains reflectance data from both of the light sources. Additional measurement devices are carried by the implement for collecting additional soil property data, such as electrical conductivity, pH, and elevation, which can be used together with the optical data to determine variations in soil organic matter.

The invention provides a system for using optical mapping for producing a 3 dimensional mapping of the characteristics of a body; the system comprising measuring the movement of at least one registration mark on a capture sheet along a pre-determined axis and means for using this measurement of the movement of the at least one registration mark to provide an indicator of the characteristics of the body. The invention also provides an apparatus for measuring body characteristics and a method of measuring body characteristics.

The invention provides an optical mapping method. The method includes the following steps: providing a handheld device which comprises an input unit, a processor and a light source, receiving input information by the input unit, conducting image inversion on the input information through the algorithm to obtain an image inversion pattern, outputting promoting message through a processor to prompt a user to move the handheld device according to the image inversion pattern to enable light beams of a light source to form an optical track in a time interval.

A method for correctly machine - reading pattern and word in countermark on partially damaged valuable document includes using two - valued phase patter to present word and pattern then forming a frame of multigrey scale pattern by using optical mapping conversion device to diffuse each pixel element on original two - valued phase pattern to complete surface of countermark, using orientation angle size of two adjacent sets of speckle Young's interference fringe to present pixel element grey scale. The said method can be used to carry out correct machine - read on damaged document with residual area of 75 % original document.

A computer database system for storing, processing, displaying, and analyzing single molecule data is capable of managing and processing variously formatted, different kinds of single molecule data and displaying subsets thereof upon instructions by a user. A component-based architecture is implemented where the processing and the displaying are separately performed. The data is dynamically loaded for processing as needed. Embodiments of computer database systems can be utilized in managing single molecule data, particularly image data derived from single molecule images. Such single molecule images may be generated by a variety of technologies, e.g., optical mapping, atomic force microscopy (AFM), scanning tunneling microscopy (STM), and flow cytometry. Systems may be deployed over a computer network. One or more additional databases may be included which are interconnected through a network.

The invention discloses a method for optical imaging of a living myocardial sheet, and belongs to the technical field of optical imaging. The method for optical imaging of a living myocardial sheet comprises the following steps of step 1: perfusion of an isolated heart; step 2: loading of a calcium-sensitive fluorescent dye and a voltage-sensitive fluorescent dye; step 3: preparation of a living short-axis myocardial sheet; and step 4: optical mapping. The method combines optogenetic technique, optical mapping and living myocardial sheet technology, performs the short-axis sectioning of the heart of a photogenetical transgenic mouse, and adopts an ultra-high-rate camera for optical mapping for detecting and analyzing the conduction characteristics of myocardial membrane potential and calcium transients after blue light stimulation, thereby opening up a new research method for the physiology and pathology of the heart.

The present invention discloses a quantification method of radiation performance indexes of an optical mapping camera. The quantification method comprises the following steps of (1) based on least square image matching, deriving and obtaining camera radiation performance indexes influencing mapping precision; (2) based on the step (1), analyzing the influence rule of each index on the mapping matching precision; (3) for the purpose of achieving decorrelation decoupling of the camera radiation indexes and scene information, proposing scene information characterization parameters; (4) based on the step (2) and step (3), constructing an association model between the camera radiation indexes and the mapping precision; and (5) combined with the model constructed in the step (4), proposing a camera radiation index quantification method. According to the method, the association model between the camera radiation indexes and the mapping precision is established, and the model can be used for providing theoretical direction and technical support for quantification and optimal design of mapping camera radiation performance indexes and performance prediction.

A set of pathogenic genes of neuropsychiatric retardation and advanced cognitive disorder, detection primer and kit thereof are provided. By combining the whole-genome sequencing and the next-generation of optical mapping technology, one can determine the mutation sites of SLC16A2, KIF4A, MED15 and FAM83G and five structural variant genes (CT55, DTX2P1-UPK3BP1-PMS2P11, EBF2, FAM173B, FAM173B and TMTC1). The detection of a mutation in said genes can assist in the diagnosis of neuropsychiatric retardation and advanced cognitive disorder.

The invention provides a calculation method, an experiment method and an experiment device for a V-shaped cutting groove tip stress intensity factor under pure shear loading, and the calculation method is based on a caustic method and comprises the steps: 1, selecting a plane to-be-measured object with a V-shaped cutting groove, and building an optical mapping relation between the plane of the to-be-measured object and a reference plane; 2, establishing a V-shaped cutting groove tip stress field expression; 3, establishing a relational expression between the initial curve radius r0 of a caustic and a stress intensity factor KII; 4, determining a caustic mapping equation of the V-shaped cutting groove under pure shearing loading; 5, establishing a relational expression between the characteristic length Dmax and the initial curve radius r0 of the caustic; and 6, determining the V-shaped cutting groove tip stress intensity factor KII under pure shear loading. The calculation method of theV-shaped cutting groove tip stress intensity factor KII under pure shear loading is obtained through research, and a new way is provided for obtaining the V-shaped cutting groove tip stress intensityfactor. The method has good precision and numerical stability.

System, process and software arrangement produces high resolution, high accuracy, ordered, genome wide haplotyped maps from single molecule based approximate ordered maps and the location of genes responsible for genetic diseases are determined by performing an association study using a population of genome wide haplotyped maps. This can also be used with Optical Mapping data to assemble a genome wide haplotyped restriction map based on multiple distinguishable restriction enzymes. This invention can also be used with any other single molecule process that can produce approximate ordered physical map from randomly broken DNA pieces of a particular genome.

The system and method non-linear optical mapping of a detector array to expand the field of view. Outer edges of the sensor array having lower resolution spatial resolution in exchange for an expanded field of view. A lens is used to distort incoming signals to provide the expanded field of view and a processor is used to remove the distortion to provide the actual spatial angles for the incoming signals suing a look up table or an algorithm. The lens may create radial or linear distortion.