The invention discloses a medicine for treating ozostomia. The medicine comprises internal decoction and mouthwash, wherein the internal decoction is prepared from the following raw material medicines: radix bupleuri, astragalus, poria cocos, wolfberry fruit, semen cassiae, bighead atractylodes rhizome, jasmine, mangnolia officinalis, dried tangerine or orange peel, Chinese yam, elecampane, sea-buckthorn, glossy privet fruit, eclipta, oldenlandia diffusa, houttuynia cordata, dandelion, polygonum cuspidatum, oriental wormwood, folium eriobotryae, bulbus fritillariae cirrhosae, wax gourd seed, rhizoma phragmitis and liquorice; the mouthwash is prepared from the following raw material medicines: semen coicis, purslane, radices trichosanthis, caulis bambusae in taeniam, honeysuckle and mint. The medicine is used for treating ozostomia, and the total effective rate is 100 percent.