33 results about "Periodontal Disorder" patented technology

The present invention relates to oral care compositions which provide a means to deliver actives which are useful in the prevention, treatment and / or management of dental and related tissue conditions, including dental caries, dental cavities, microbial flora, tartar, periodontal and related gum disease. In addition, the present invention may be used in the healthy maintenance of teeth and gums. Further aspects of the present invention are related to the present compositions being useful to whiten teeth and otherwise favorably impact the cosmetic appeal of the teeth and gums of a subject or patient. A further aspect of the present invention is directed to the inclusion of effective amounts of colostrum in dental care compositions for the unexpectedly high efficacy such formulations provide in inhibiting, reducing or otherwise preventing microbial growth, dental caries, plaque, cavities and gum disease, including periodontal disease. The use of colustrum with other enzymes as otherwise described herein represents a particularly preferred embodiment for use in the present invention because of the unexpected antimicrobial activity exhibited by the enzyme combination.

Disclosed are a liquid type dentifrice composition primarily containing silver particles which is drawn out in foam state when used to brush teeth to prevent the liquid dentifrice from flowing down during tooth-brushing, resulting in effective and convenient tooth-brushing function and exhibit bactericidal action and protect mouth and teeth from periodontal disease and other mouth diseases because of original properties of silver ingredients in the dentifrice composition; and, in addition to, a mousse type dentifrice formulation using the same that improves aesthetic property and product quality thereof. The inventive dentifrice composition primarily containing silver particles useful for mouthwash comprises: at least one surfactant selected from a group consisting of 0.5 to 3% by weight of SQdium lauryl sulfate, 0.05 to 1% by weight of sodium sarcosine laurate, 0.5 to 5% by weight of alkyl polyglucoside and 0.5 to 3% by weight of sucrose fatty acid ester; at least one wetting agent selected from a group consisting of 30 to 80% by weight of sorbitol solution and 0.5 to 5% by weight of glycerine; at least one solubilizing agent selected from a group consisting of 0.1 to 1% by weight of hydrogenated polyoxyethylene caster oil and 0.1 to 1% by weight of polyoxyethylene sorbitan monolaurate effective to solubilize flavor and active ingredients; 0.01 to 10% by weight of silver particles with bactericidal action; and the balance of purified water relative to total weight of the composition. The inventive mousse type dentifrice formulation comprising the above liquid dentifrice composition is prepared by steps of: introducing the dentifrice composition comprising silver particles as essential ingredient into a foam generating receptacle with constant capacity; and drawing the composition in foam form through outlet of the receptacle in order to brush teeth.

The invention relates to sushuang (a brand) bioactivity mineral powder as well as a preparation method and application of the sushuang bioactivity mineral powder, and aims at solving the problems of unsatisfactory effect, tooth injury, high price and inconvenience for use in the conventional method for preventing decayed teeth and treating dentin hypersensitivity. The mineral powder is prepared by part or all of the following components: 35-55 parts of SiO2, 10-30 parts of CaO, 0.1-35 parts of K2O, 3-8 parts of P2O5, 0-20 parts of CaF2 and 0-30 parts of Na2O. The preparation method comprises the following steps of: melting the components at the temperature of 1350 DEG C, cooling, dewatering, and grinding. The mineral powder serves as an active constituent to be used for treating tooth and periodontal diseases to promote bone growth, and is convenient to use, good in treatment effect and moderate in price.

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-Ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and / or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and / or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).

This present invention discloses inhibitors of matrix metalloproteinases, and novel methods of their use. The inhibitors may be useful for treating conditions that involve enhanced activity of at least one of the matrix metalloproteinases neutrophil collagenase (MMP-8), aggrecanase, hADAMTS1, and gelatinase A (MMP-2). Such disorders may include, but are not limited to, degenerative joint disorders (e.g., osteoarthroses), spondyloses, chondrolysis associated with joint trauma or prolonged joint immobilization (often occurring after meniscus or patellar injuries or ligament tears), connective tissue disorders (e.g., collagenoses), wound healing disturbances, periodontal disorders, chronic disorders of the locomotor system (e.g., inflammatory, immunologically, or metabolism-related acute and chronic arthritides), arthropathies, myalgias, or disturbances of bone metabolism.

The invention relates to a production method and application of a nutgall effective part used for preventing and treating periodontal disease and inflammatory bowel disease. The production method is characterized by carrying out the following steps: taking a nutgall medicinal material; smashing the nutgall medicinal material; refluxing and extracting the smashed nutgall for 1-5 times in the presence of solvents (ethanol water and ethyl acetate), wherein extraction is carried out for 1-5 hours every time; mixing extract; carrying out column chromatography on the obtained mixed extract with polyamide resin or macroporous adsorption resin on exchange equipment; carrying out liquid chromatography-mass spectrometry determination and collecting fraction with the mass-to-charge ratio of 321 + / - 1and 635 + / - 1, and drying to thus obtain the nutgall effective part. The obtained nutgall effective part can strengthen teeth and gingival and is used for alleviating sore and weak teeth, chewing disability, looseness and displacement, gingival bleeding, mouth and tongue sores as well as swelling and pain in throat which are caused by the periodontal disease; and the nutgall effective part also can alleviate diarrhea and abdominal pain, mucus and bloody purulent stool as well as intestinal mucosal injury which are caused by the inflammatory bowel disease.

The invention relates to a functional toothpaste. The toothpaste contains natural plant active ingredients including bamboo leaf flavone, a thamnolia vermicularia extract, a snow lotus herb extract, arhodiola rosea extract and a lucid ganoderma extract, and natural mineral active ingredients including alabaster, edible salt, limonitum powder, turtleback gypsllill powder and limonite powder. According to the invention, due to addition of various active ingredients of natural medicinal plants / minerals, various oral and periodontal diseases can be prevented; meanwhile, the toothpaste enables teeth to be whiter under the condition that the tooth axis is not damaged, so bacteria on the surfaces of the teeth are effectively cleaned, and the situation that the bacteria and products of the bacteria endanger the health of surrounding organs is reduced; and experiment results prove that the functional toothpaste provided by the invention can well prevent and treat decayed teeth compared with common toothpaste.

The invention discloses manuka honey toothpaste for pregnant women. The toothpaste consists of the following components in parts by mass: 20-30 parts of water, 2-4 parts of coco-glucoside, 1-3 parts of manuka honey, 0.1-0.5 parts of borneol, 0.1-0.3 parts of an echinacea purpurea extract, 0.01-0.03 parts of tea tree oil and 30-60 parts of glycine. The invention further discloses a preparation method of the manuka honey toothpaste. The toothpaste disclosed by the invention contains New Zealand manuka honey, and with UMF in the manuka honey, the toothpaste has effects of resisting bacteria, resisting inflammation and preventing decayed teeth; the natural manuka honey, as a unique biological substance, is capable of preventing and repairing periodontal diseases; and the toothpaste disclosed by the invention, with the echinacea purpurea extract, fresh ginger oil and the tea tree oil which have an effect of sterilizing, can also improve immunity.

An in vitro method for assessing or predicting the response of a human patient to periodontal disease treatment is disclosed. The method is based on determining insights to biomarker proteins. Accordingly, the concentration of a specific protein combination is measured in a saliva sample of a patient. One such combination is at least one of interleukin 1 [beta] (IL1 [beta]) and matrix metalloproteinase 8 (MMP8), and [alpha] 1 acid glycoprotein (A1AGP). At least one value reflecting the combined concentration of the protein is determined based on the measured concentration. The at least one value may indicate a likelihood that the human patient has or will successfully treat periodontitis. The at least one value may be compared to at least one threshold that in the same manner reflects a combined concentration associated with successful treatment of periodontitis. The comparison allows evaluation of whether the test value is an indication of the patient's periodontal treatment status.

The invention provides a method for establishing a rat periodontitis model, and belongs to the technical field of periodontology. The rat periodontitis model is established by injecting drugs into a plurality of rats to be modeled; the rats suffering from periodontitis are divided into a hard food feeding group and a soft food feeding group, hard food is fed to the rats suffering from periodontitis in the hard food feeding group, and soft food is fed to the rats suffering from periodontitis in the soft food feeding group; and maxilla specimens in molar regions at the two sides of the rats suffering from periodontitis are separated, and local tissues are scanned to confirm the establishment of a mechanical load composite model of the rats suffering from periodontitis . Through iconographicanalysis on to-be-modeled tissues of the rats, it is proved that the pathological change of the local periodontal tissues of the rats suffering from periodontitis is detected by changing the hardnessof the food, and the pathological process of clinical dentition defects accompanied by periodontitis affected teeth is fully simulated; and an innovative method is provided for designing and researching dentures of patients with periodontal diseases and dentition defects accompanied by the periodontal diseases.

The invention relates to an oral mucosa medicament slow release preparation for treating oral periodontal disease, which comprises an oral mucosa contact layer and an unbonded close layer, wherein the oral mucosa contact layer comprises the components of anti-biotic medicines and accessories in weight proportion of 2-20:80-98; and the unbonded close layer comprises an unbonded low water-solubility high molecular polymer. The preparation comprises the following steps: preparing a corresponding contact layer paster and water solution through uniformly mixing the anti-biotic medicine and the accessories; coating water solution of the unbonded low water-solubility high molecular polymer on a single surface of the contact layer paster; and drying to obtain the oral mucosa medicament slow release preparation. The oral mucosa medicament slow release preparation has convenient administration, long medicament release, uniform release speed, strong target property, strong bonding property with membrane, and the like; meanwhile, the preparation method has simple operation, low cost and environment protection, and is suitable to industrialized production.

The invention relates to a periodontal disease detection kit and a use method thereof, which can detect interleukin-1beta and interleukin-18 in saliva through an immunological method to judge periodontal related diseases and distinguish the morbidity progress and the treatment effect of periodontal surface soft tissue and hard tissue inflammation (namely gingivitis and periodontitis). According tothe kit and the detection method which are simple to operate and easy to distinguish, the progress degree of periodontal tissue related inflammation can be recognized by using a scientific method ina breakthrough manner, accurate objective evidences are provided for clinic, and the application benefit of self-inspection prevention of periodontal diseases is expanded.

A three-in-one tooth-cleaning device structured as a toothpick, an interdental brush, and a floss pick includes a main body and an interdental elastic-bristle portion. The main body is integrally formed of a first plasticized material by injection molding and is structured as a floss pick at one end and as a toothpick at the opposite second end. The interdental elastic-bristle portion is integrally formed by injection molding a second plasticized material over the periphery of the main body in a section adjacent to the second end of the main body and forms a plurality of bristles. The second plasticized material has a lower hardness than the first plasticized material. The three-in-one tooth-cleaning device can be carried around to perform diversified, thorough, and effective removing operations on the dental plaque or food debris on and / or between teeth anytime and anywhere to prevent dental caries (especially interdental caries) and periodontal disease.

The invention provides application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis, and magnesium hydride toothpaste. The weight percentage of magnesium hydride in the composition or the magnesium hydride toothpaste is 1-3%. The toothpaste has the effects of sterilizing, resisting inflammation, resisting oxidation, removing tooth stains, improving breath or halitosis, relieving redness, swelling and bleeding of gingiva and gingival recession, and improving periodontitis symptoms. The invention also discloses application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis. According to the invention, a proper amount of magnesium hydride fine particles are added into the toothpaste body;and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with an anti-inflammatory effect, and also can inhibit alveolar bone absorption. The composition containing magnesium hydride is safe to use, and can effectively prevent the occurrence and development of periodontal diseases after long-term use.

The invention belongs to the field of oral care products and concretely relates to toothpaste and a preparation technology thereof. According to the preparation technology, an oral care product is prepared by mixing a plurality of anti-inflammatory components, antibacterial ingredients and base ingredients, and by adding hydrogen peroxide and lysozyme, the bacterial microorganisms in the oral cavity can be fully killed. The oral care product has effects of preventing oral bacterium breeding and preventing and treating periodontal diseases. The anti-inflammatory components can solve oral problems of a user suffering from oral diseases to a certain extent.

A novel peptide and a composition including the peptide are disclosed. The composition may be a pharmaceutical composition, a quasi-drug composition, a dietary supplement, or a food composition. A polynucleotide encoding the peptide and an expression vector including the polynucleotide are also disclosed. The peptide promotes regeneration of hard tissue and is useful for treating dentin-dental pulp diseases or periodontal diseases.

Provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in alleviating or preventing periodontal disease, wherein the peptide comprises an amino acid sequence present in an alpha-S2 casein precursor, said sequence comprising 3 or more amino acids, and not comprising at its N-terminus the N-terminal amino acids of the full alpha-S2 casein precursor. The peptide may alternatively be any peptide having an alpha-S2 casein fragment activity. Further provided is use of a peptide, or a derivative of a peptide, in the manufacture of a medicament effective in alleviating or preventing an effect of aging in skin, wherein the peptide comprises an amino acid sequence present in a n alpha-S2 casein precursor, said sequence comprising 3 or more amino acids, and not comprising at its N-terminus the N-terminal amino acid of the full alpha-S2 casein precursor. The peptide may alternatively be any peptide having an alpha-S2 casein fragment activity.

The objects of the present invention are: to provide a therapeutic agent and a therapeutic method for periodontal diseases and pulpal diseases, a transplant for periodontal tissue regeneration, and a method for regenerating the periodontal tissue.According to the present invention, there are provided therapeutic agents for periodontal diseases and pulpal diseases which comprise neurotrophic factors as an active ingredient.

A novel peptide and a composition including the peptide are disclosed. The composition may be a pharmaceutical composition, a quasi-drug composition, a dietary supplement, or a food composition. A polynucleotide encoding the peptide and an expression vector including the polynucleotide are also disclosed. The peptide promotes regeneration of hard tissue and is useful for treating dentin-dental pulp diseases or periodontal diseases.

The invention relates to a preparation method of an extract for treating periodontal diseases. The invention aims to solve the problems of the prior slow release drugs for treating periodontal diseases, including drug tolerance after long-term administration, and no antihemorrhagic, analgesic and tissue regeneration effects. The inventive extract is prepared from panax notoginseng, salvia miltiorrhiza, drynaria fortunei, angelica sinensis, flos Lonicerae, radix glycyrrhizae, colla cornus cervi, Chinese insect wax, solid paraffin, liquid paraffin and water. The preparation method comprises the following steps of: (1) preparing panax notoginseng extract; (2) preparing the extract of salvia miltiorrhiza, drynaria fortunei, angelica sinensis, flos lonicerae and radix glycyrrhizae; and (3) mixing the extracts, adding the rest raw materials to obtain the extract for treating periodontal diseases. The extract for treating periodontal diseases has the advantages of no antibiotics or drug tolerance; and has tissue regeneration promoting effect.

A bone bioactive composition and kits comprising the composition, means for applying it and / or a metal implant are provided. The bone bioactive composition comprises a water-based salt solution comprising sodium dihydrogen phosphate and sodium chloride, and may also comprise additional elements. The composition and the kits are useful for promoting osteogenesis, particularly when a metal implant is used but also in case of periodontal diseases.

The invention discloses a traditional Chinese medicine for preventing and treating periodontal diseases and a preparation process thereof. Through the direct action of the medicine and the combinationwith the medicine channel tropism and body meridian theory, pathological products which are accumulated around the periodontium and caused by pathogenic factors and other factors such as blood stasis, pathogenic fire and pathogenic cold can be completely discharged out of the body, thereby overcoming the defect that the existing symptomatic treatment method can realize temporary relief but can not achieve a prevention effect, and avoiding the dental discomfort caused by irritation of hot feeling, cold feeling, sour taste, sweet taste and the like. The traditional Chinese medicine disclosed bythe invention has the characteristics of simple preparation, convenient use, sufficient medicine source, low cost, high effect taking speed and no toxic and side effects, and is suitable for industrialized production.

The present invention provides a tooth desensitizer product containing regenerative medicine material and a preparation method thereof; the tooth desensitizer product of regenerative medicine material is mainly made of the following raw materials: regenerative medicine material, matrix material, dispersant, gelling agent and Others; prepared by anhydrous vacuum high-speed shearing dispersion process. The present invention provides a tooth desensitizer product containing regenerative medical materials. The main functional components of the product are regenerative medicine materials, which can prevent and treat tooth hypersensitivity, and can also improve the oral environment. Caries has certain therapeutic and preventive effects.

The invention discloses an oral preparation for external use. The preparation is a composite film composed of a backing layer, a sustained-release layer, and an immediate-release layer; the backing layer is a film prepared from cellulose ether; and the sustained-release layer is A film prepared from a mixed glue composed of Chinese medicine extract, porous starch, chitosan, sodium alginate, polyvinyl alcohol, borneol, honey and purified water in a certain mass ratio; the immediate-release layer is extracted from Chinese medicine The film is prepared from a mixed glue composed of substance, porous starch, borax, carbomer, peppermint oil and purified water in a mass ratio. At the same time, the invention also discloses a preparation method of the preparation. Through the unique formula of traditional Chinese medicine extracts and the scientific design of the dosage form film layer, the present invention effectively solves the problems existing in existing oral preparations, and achieves quick effect, good sustained-release performance, and can reduce swelling and pain, remove blood stasis, and unblock meridians. It has a unique curative effect on periodontal disease, treating both the symptoms and the root causes.

The invention provides an application of magnesium hydride in preparation of a composition for preventing and treating chronic periodontitis and magnesium hydride toothpaste. The weight percentage of magnesium hydride in the composition or the magnesium hydride toothpaste is 1-3%. The toothpaste has the effects of sterilizing, resisting inflammation, resisting oxidation, removing tooth stains, improving breath or ozostomia, relieving red and swollen gums, bleeding and gingival recession, and improving periodontitis symptoms. The invention also discloses the application of magnesium hydride in preparation of the composition for preventing and treating chronic periodontitis. According to the invention, a proper amount of magnesium hydride fine particles are added into the toothpaste body, and the magnesium hydride particles can be hydrolyzed into hydrogen and magnesium ions with anti-inflammatory effects and can inhibit alveolar bone absorption. The composition containing magnesium hydride is safe to use, and can effectively prevent occurrence and development of periodontal diseases after long-term use.

The invention relates to a traditional Chinese medicine composition for treating canine periodontal disease, which comprises the following components according to parts by weight: 1-50 parts of Chloranthus glaber, 1-50 parts of ophiopogon root, 1-50 parts of dandelion, 1-50 parts of umbellate pore furgus, 1-50 parts of dried orange peel, and 1-50 parts of Herba Oldenlandiae. The traditional Chinese medicine composition for treating canine periodontal disease has the beneficial effects that Chloranthus glaber has the effects of being anti-inflammatory, expelling wind and removing dampness, promoting blood circulation and stopping pain; ophiopogon root has the effects of nourishing yin and promoting production of body fluid; dandelion has the effects of clearing away heat and toxic material and removing swelling and stasis; and Herba Oldenlandiae has the effects of clearing away heat and toxic material, eliminating carbuncle and removing stasis and inducing diuresis to alleviate edema. According to combined action of Chloranthus glaber, ophiopogon root, dandelion, umbellate pore furgus, dried orange peel and Herba Oldenlandiae, the traditional Chinese medicine composition has the effects of clearing away heat and toxic material, nourishing yin and restoring qi; and the traditional Chinese medicine composition is capable of treating ngivitis and periodontitis, has good cleaning action on oral cavity, and is capable of treating and preventing canine periodontal disease.

The present invention relates to a method for preparing a cartilage product comprising a protein hydrolysate with a degree of hydrolysis comprised between 0.5% and 3.0%, at least one glycosaminoglycan and at least one growth factor. The present invention also relates to the cartilage product obtainable through said method. Said cartilage product is useful in the treatment or prevention of wounds, ulcers, burns, psoriasis, osteoarthritis, synovitis, osteoporosis, osteopenia, diseases of the tendons and ligaments, periodontal diseases, signs of skin aging, the harmful effects of ultraviolet radiation exposure or stretch marks.

The invention discloses a compound metronidazole tablet for pets, and a preparation method of the compound metronidazole tablet. The compound metronidazole tablet mainly comprises the following components in parts by weight: 20 parts of metronidazole, 15 parts of fenbufen, 40-60 parts of diluent, 3-10 parts of disintegrating agents, 2-5 parts of adhesives, 5-15 parts of phagostimulant and 0.25-2.0 parts of lubricants. The compound metronidazole tablet is suitable for the periodontal diseases, including gingivitis, periodontitis, gingival abscess, acute dental infection caused by clostridium and the like, of pets, has a good prevention and treatment effect and safe quality, is convenient for clinical medication of the pets, and has a good curative effect for the periodontal diseases caused by anaerobic infection of pets. After being used, the compound metronidazole tablet is good in oral absorption, and the bioavailability is 80% or above.