Methods, uses and kits for monitoring or predicting response to peripheral disease treatment

A technology for periodontal disease and periodontitis, applied in the field of treatment response and response evaluation, can solve the problems that dentists cannot perform routine operations

Pending Publication Date: 2020-11-17
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the available methods for performing this assessment involve a labor-intensive process that makes it impossible for the dentist to perform routinely on each patient and / or visit, and which is impossible to perform by the user (self-diagnosis)

Method used

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  • Methods, uses and kits for monitoring or predicting response to peripheral disease treatment
  • Methods, uses and kits for monitoring or predicting response to peripheral disease treatment
  • Methods, uses and kits for monitoring or predicting response to peripheral disease treatment

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Embodiment Construction

[0042] In a general sense, the present invention is based on the insight that certain combinations of protein biomarkers in saliva samples of human patients can be used to assess or predict patient response to periodontal disease treatment. A combination of biomarkers in saliva can differentiate a successful response to periodontitis treatment from an unsuccessful response to periodontitis treatment. This insight is based at least in part on the finding that the usefulness of a biomarker for diagnosing periodontal disease (eg, prior to treatment) does not necessarily mean that it is also useful for monitoring treatment of that periodontal disease. The current publication proposes clinical definitions of various grades of treatment response, and identifies combinations of salivary protein markers that enable the measurement of post-treatment or pre-treatment (for prediction) concentrations of the combination of salivary protein markers. Assessment or prediction of treatment res...

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Abstract

An in vitro method for assessing or predicting the response of a human patient to periodontal disease treatment is disclosed. The method is based on determining insights to biomarker proteins. Accordingly, the concentration of a specific protein combination is measured in a saliva sample of a patient. One such combination is at least one of interleukin 1 [beta] (IL1 [beta]) and matrix metalloproteinase 8 (MMP8), and [alpha] 1 acid glycoprotein (A1AGP). At least one value reflecting the combined concentration of the protein is determined based on the measured concentration. The at least one value may indicate a likelihood that the human patient has or will successfully treat periodontitis. The at least one value may be compared to at least one threshold that in the same manner reflects a combined concentration associated with successful treatment of periodontitis. The comparison allows evaluation of whether the test value is an indication of the patient's periodontal treatment status.

Description

technical field [0001] The present invention is in the field of oral care and relates to saliva based assessment of response to periodontal disease treatment. In particular, the present invention relates to a kit, use and method for assessing or predicting response to treatment of a patient suffering from periodontal disease. Background technique [0002] Inflammation of the gums or gingivitis is a non-destructive periodontal disease mainly caused by the adhesion of dental bacterial biofilm or plaque to the tooth surface. If undetected and treated, reversible gingivitis typically triggers inflammation of the tissue surrounding the tooth (the periodontal tissue), a condition defined as periodontitis, which is irreversible and leads to tissue destruction and alveolar bone missing, and eventually lead to tooth loss. As gum disease develops, there are often clinical signs and symptoms associated with it, such as gum swelling, changing color from pink to dark red, bleeding gums...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/18G01N2800/52G01N2800/60G01N2333/4727G01N2333/4728G01N2333/4742G01N2333/545G01N2333/96494
Inventor G·库伊杰曼M·A·范哈特斯坎普A·H·耳麦勒C·格拉斯P·普雷肖J·泰勒I·L·C·察柏尔M·M·格兰特M·K·J·德加格
Owner KONINKLJIJKE PHILIPS NV
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