4 results about "Osteoarthroses" patented technology

The invention relates to a tendon-stretching pain-relieving plaster, which is prepared by soaking a plurality of Chinese herbal medicines such as Aristolochia delavayi, Chinese actinidia root, herba aristolochiae, kadsura pepper stem, pseudo-ginseng and yellow lead in clear sesame oil and decocting into the plaster for external use, and the tendon-stretching pain-relieving plaster is mainly prepared from traditional Chinese medicines, has the effects of clearing away heat and toxic materials, diminishing inflammation and relieving pain, is low in cost, has the effects of dredging tendons and activating blood, dispelling wind and eliminating dampness, and stretching tendons and relieving pain, and is suitable for rheumatoid arthritis. The traditional Chinese medicine composition is free of side effects and good in curing effect, and can be used for treating osteoarthropathy such as rheumatic arthritis, osteoproliferation and traumatic injury.

The utility model relates to a traditional Chinese medicine fumigating and washing device, in particular to an external traditional Chinese medicine fumigating and washing device for treating rheumatic osteoarthropathy, which comprises a boiling fumigating instrument, a movable connecting arm, a steam hose, a fumigating and washing cover, a mounting frame, an interactive clamping block and an elastic piece, the fumigation and washing cover is connected to the end, away from the boiling fumigation instrument, of the movable connecting arm, a steam hose is fixed to the movable connecting arm, one end of the steam hose is inserted and fixed into the boiling fumigation instrument, the other end of the steam hose is inserted and fixed to the fumigation and washing cover, and four mounting frames are symmetrically connected to the two sides of the top of the fumigation and washing cover. The two mounting frames on each side are each connected with an interaction clamping block in a sliding mode, and elastic pieces are connected between the mounting frames and the interaction clamping blocks. By designing the interactive clamping blocks and the elastic pieces, the towel is ensured to be stably fixed on the fuming and washing cover, and the problem that the towel is easy to fall off is effectively solved.

This invention discloses a neutralizing nanobody targeting soluble interleukin-17 receptor D (sIL-17RD), its preparation method, and its applications. The heavy chain variable region (VHH) of this nanobody contains a heavy chain complementarity-determining region 3 (CDR-H3) that specifically binds to sIL-17RD, with a length of 10 amino acids and containing 2–6 lysine residues. This invention provides four nanobodies: CQ5, CQ13, CQ11, and CQ6, corresponding to well-defined CDR-H1, CDR-H2, and CDR-H3 sequence combinations. This nanobody can specifically bind to and neutralize the biological activity of sIL-17RD, reducing chondrocyte death, promoting proliferation, and maintaining extracellular matrix homeostasis by inhibiting the P2rx7-NLRP3 inflammasome-mediated chondrocyte pyroptosis pathway. This invention also protects the nucleic acid encoding this nanobody, the recombinant expression vector, the host cell, the pharmaceutical composition, and the preparation method. The nanobodies described can be used to prepare drugs for the prevention and treatment of inflammatory osteoarthritis and other osteoarthritis. They can inhibit synovitis, reverse cartilage and subchondral bone degeneration, and relieve pain, showing promising application prospects.

The present invention relates to a composition for intra-articular use in the treatment of osteoarthropathy (OA) comprising cross-linked hyaluronic acid or a salt or derivative thereof, clodronate or an equivalent salt thereof, and an acetate buffer.