36 results about "Osteoarthroses" patented technology

The present invention discloses β-diketones, γ-diketones or γ-hydroxyketones or analogs thereof, that activate Wnt / β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

The invention discloses an external traditional Chinese medicine bag prescription, a medicine bag and a using method thereof, and belongs to the field of traditional Chinese medicines. The medicine bag prescription consists of the following components in parts by weight: 10-30 parts of dried ginger, 5-15 parts of herba menthae, 10-20 parts of rhizoma curcumae longae, 10-20 parts of radix angelicae, 5-15 parts of cassia twig, 2-10 parts of radix angelicae sinensis, 2-10 parts of rhizoma ligustici wallichii, 2-10 parts of herba asari cum radice and 50-90 parts of folium artemisiae argyi. The traditional Chinese medicine bag, which is manufactured on the basis of the prescription, is relatively strong in effects of promoting blood circulation and removing stasis, diminishing inflammation and alleviating pain, warming and activating meridians, dispelling cold and the like through a synergistic effect among the various components, and the traditional Chinese medicine bag, in combination with a massaging effect, is capable of promoting blood circulation and promoting metabolism through hot compress; the traditional Chinese medicine bag is relatively high in comfort degree and can be widely applied to health care industry as well as to the treatment of osteoarthropathy such as cervical spondylosis, lumbar spondylosis and the like and diseases of deficiency-cold; meanwhile, the traditional Chinese medicine bag has the advantages of being low in cost, convenient to use, high in safety, free from side effects, large in operating area, rapid to take effects, significant in curative effect and the like; and the using method provided by the invention is simple to operate, easily available in raw materials and low in cost, and conforms to the market demands of traditional Chinese medicine and the health care industry.

The invention provides a preparation method for health wine. The health wine is prepared from traditional Chinese medicines, sugar, fresh grapes, hawthorn and the like through natural fermentation. The health wine has a health function, can be drunk by middle-aged and aged people suffering from hyperostosis, bony spur and osteoarthropathy and persons with high blood pressure and high blood fat, has no toxic or side effects, does not contain any additive, and is naturally green, and the preparation method is simple and can be used for small-batch or batch production.

This present invention discloses inhibitors of matrix metalloproteinases, and novel methods of their use. The inhibitors may be useful for treating conditions that involve enhanced activity of at least one of the matrix metalloproteinases neutrophil collagenase (MMP-8), aggrecanase, hADAMTS1, and gelatinase A (MMP-2). Such disorders may include, but are not limited to, degenerative joint disorders (e.g., osteoarthroses), spondyloses, chondrolysis associated with joint trauma or prolonged joint immobilization (often occurring after meniscus or patellar injuries or ligament tears), connective tissue disorders (e.g., collagenoses), wound healing disturbances, periodontal disorders, chronic disorders of the locomotor system (e.g., inflammatory, immunologically, or metabolism-related acute and chronic arthritides), arthropathies, myalgias, or disturbances of bone metabolism.

An ointment for curing bone arthropathy is a medicine for curing bone arthropathy, which overcomes the defects of other methods. The ointment contains the traditional Chinese raw medicines with the following weight proportion: pangolin, angelica, hemlock parsley, dried body of ground beetle, earthworm, american lopseed, siebold wildginger herb, szechuan aconite, wild aconite, eucommia, leatherleaf millettia, achyranthes root, turmeric, motherwort, Chinese lovage, obscured homalomena rhizome, nodular branch of pine, cibotium barometz, muskiness, rhizoma corydalis and camphor. The preparation method includes the following steps: fully frying pangolin, angelica, hemlock parsley, dried body of ground beetle, earthworm, american lopseed, siebold wildginger herb, szechuan aconite, wild aconite, eucommia, leatherleaf millettia, achyranthes root, turmeric, motherwort, Chinese lovage, obscured homalomena rhizome, nodular branch of pine and cibotium barometz with sesame oil and removing slag; refining oil until water drops become bead and then adding yellow lead; evenly stirring and obtaining the ointment; immersing the ointment in water for 15 to 20 days to clearing fire toxin, adding muskiness, rhizoma corydalis and camphor when ointment is spread. The curing result is as follows: the total number of the cases is 1,763, wherein, 1,473 cases are healed, 290 cases get better and 36 cases are unhealed, thus the total effective rate is 97.8 percent.

The invention discloses a Chinese medicine preparation for treating obstructive bone nonunion caused by callus, which belongs to the field of traditional Chinese medicines. The Chinese medicine preparation for treating the obstructive bone nonunion comprises the following crude drugs in percentage by weight: 15 percent of drynaria, 5 percent of myrrh, 10 percent of cinnamon, 15 percent of achyranthes bidentata, 4 percent of gastrodia elata, 6 percent of gentiana macrophylla, 15 percent of semen coicis, 6 percent of American lopseed, 6 percent of peach kernels, 8 percent of sessileflower acanthopanax barks, 6 percent of herb pyrolae and 4 percent of root-barks of tree peony. The preparation has the efficacies of disintegrating blood stasis, mending blemishes, dispersing blood stasis and relieving pain, performing reunion of bone, and accelerating generation of the callus, and has the functions of improving the chondrocyte, putting off cell degeneration and reducing the pathological change of osteoarthrosis, and has the characteristics of safety and anodynia.

The invention provides a traditional Chinese medicine composition for treating osteoarthropathy and a preparation thereof. The traditional Chinese medicine composition comprises the following components: coptis chinensis, scutellaria baicalensis, golden cypress, golden cypress and golden cypress. The traditional Chinese medicine composition and preparation thereof have good actions of promoting blood circulation to remove blood stasis, restoring menstrual flow, promoting qi circulation and removing obstruction in the collaterals, removing stasis and enriching blood, relieving pain and dispelling melancholy and have a remarkable curative effect on clinical patients with osteoarthropathy from clinical symptoms, sign improvement and relapse control.

The invention relates to a decoction processing technology of a black plaster for treating osteoarthropathy. The technology comprises the following steps: step 1, material preparation: raw materials are placed in a bearing assembly of a bearing mechanism, then, a first driving assembly and a second driving assembly are started, a third connecting column of the bearing assembly moves downwards along a vertical direction and rotates, and a filter cartridge of the bearing assembly settles to a lower layer of the decocting box; step 2, first-time decocting; step 3, stirring and mixing; step 4, plaster decoction circulation; step 5, raw material slitting; step 6, space division; step 7, second-time decocting; step 8, full mixing; and step 9, self-cleaning. According to the decoction processing technology, technical problems that some traditional Chinese medicines need to be decocted for the second time, a patient needs to take mixed liquid of medicine liquid decocted for the second time, effective components can be fully extracted from the traditional Chinese medicines through the second-time decocting, and then, a good effect can be achieved are solved.

The invention relates to the field of traditional Chinese medicine, in particular to traditional Chinese medicinal liquor for treating osteoarthrosis. The traditional Chinese medicinal liquor is mainly prepared by soaking more than fifty traditional Chinese medicinal materials in rice wine, wherein the traditional Chinese medicinal materials include Fructus Rubi, Rhizoma Alpiniae Officinarum, Rhizoma Polygonati, Semen Coicis, Radix Melastomatis Normalis, Rhizoma Cibotii, Herba Epipremni Pinnata, Radix Rivularis Rivulare, Caulis seu Radix Parthenocissi Heterophylli, Radix Parthenocissi Himalayanae, Radix Wikstroemiae Indicae, Herba Bidentis Bipinnatae, Rhizoma Paridis, Cortex Eucommiae, Radix Flemingiae Phrippinensis, Ramulus Uncariae Cum Uncis, Folium Mahoniae and the like. According to the principle of treatment of both symptoms and root causes and the formulation principle of monarch, minister, assistant and guide medicines in theories of traditional Chinese medicine and on the basis of pathogenesis of osteoarthrosis, the traditional Chinese medicinal liquor is capable of eliminating rheumatism pain and toxins aiming at lesions, softening hyperplasia of degenerative joints, repairing damaged articular cartilage and synovial membrane, promoting regeneration power of cartilage and synovial membrane, promoting generation of synovial fluid and repairing soft tissues of lesion bone joint to recover cartilage protective layers of joint organs and recover normal physiological functions. In addition, the traditional Chinese medicinal liquor is capable of conditioning bodies integrally and realizing treatment of both symptoms and root causes, and osteoarthrosis cured by the traditional Chinese medicinal liquor is less prone to relapse.

The invention belongs to the field of traditional Chinese medicine preparations and in particular relates to a medicament composition for treating osteoarthrosis. The medicament composition is prepared from the following medicinal raw materials including Asian tree fern rhizome, herba epimedii, pubescent angelica roots, drynaria rhizome, radix dipsaci, loranthus parasiticus, caulis spatholobi, prepared radix rehmanniae, radix aucklandiae, frankincense volatile oil, myrrh volatile oil and processed products of fructus psoraleae. The medicament composition is capable of effectively treating osteoarthritis and lumbar muscle strain caused by deficiency of liver and kidney, qi stagnation, blood stasis and obstructed channels and collateral and also effectively weakening hepatotoxic side effects of original products and has good clinical therapeutic efficacy.

The invention provides a patient tracking system for bone joint nursing, and the system comprises at least one patient terminal which receives tracking information inputted by a patient, at least one medical care terminal used for medical care personnel to input the osteoarticular disease information and the current treatment scheme of the patient, a storage module used for receiving and storing the tracking information, the osteoarticular disease information and the current treatment scheme of each patient, a prediction module used for predicting a predicted treatment process according to the osteoarticular disease information and the current treatment scheme, an acquisition module used for acquiring the actual clinical manifestation of the patient at the predicted time node, an analysis module used for performing processing according to the predicted treatment process and the actual clinical manifestation to obtain an analysis result and outputting an alarm signal according to the analysis result, and a feedback module used for reminding medical staff of the condition that the current treatment scheme does not improve the illness state of the patient according to the alarm signal, so that the medical staff can adjust the current treatment scheme of the patient. The beneficial effect is that the medical staff can adjust the current treatment scheme in time according to the illness state of the patient.

The plaster for treating osteoarthropathy is prepared with angelica, Chuanxiong rhizome, almond, safflower, papaya and other Chinese medicinal materials. It has the functions of relaxing the muscles and joints, promoting blood circulation, dispersing blood clots, eliminating cold evil, strengthening Yang, etc. and can eliminate adhesion of muscular fasciae, remitting pain, inhibiting joint deformation and restore the functions of joints and muscles to cure diseases caused by adhesion of periosteum and muscular fasciae. The present invention has the advantages of convenient use, no pain produced, high curative effect, fast pain relieving, etc.

The invention belongs to the medical field, and in particular to a small needle knife structure for treating osteoarthropathy. Aiming at the problems that the existing small needle knife can not be replaced according to the use condition, not convenient to use, and the use effect is not good. The small needle knife includes a knife handle and a needle bar, and connecting plates are fixedly installed on both sides of the upper end of the knife handle. A light tube is fixedly installed on one side of the outer surface of the knife handle at the lower end of the connecting plate. A connecting seat is fixedly installed in the middle of the lower end of the knife handle. The lower end of the needle bar is fixedly connected with a cutter head, the outer surface of the needle bar is engraved witha scale bar, and the inner front end of the lamp tube is fixedly provided with a laser lamp body. The invention can quickly and conveniently replace the needle bar according to the use situation, makes the small needle knife more convenient to use, and can be illuminated by a laser light when in use, thereby being convenient for the use of the small needle knife and at the same time improving theaccuracy of the use of the small acupuncture knife.

The invention relates to a traditional Chinese medicine preparation and a preparation method thereof, in particular to a formula and preparation process of a traditional Chinese medicine preparation for treating osteoarthropathy. The formula comprises the following raw materials in parts by weight of 35-40 parts of radix angelicae sinensis, 35-40 parts of cortex cinnamomi, 25-30 parts of herba cynomorii (Yeermaidike), 25-30 parts of herba asari, 10-15 parts of caulis akebiae, 25-30 parts of radix paeoniae alba, 10-15 parts of cupparis spinosa (Bolike fruit), 15-30 parts of dried chilli, 5-15 parts of herba menthae and 1.0-1.5 parts of borneol. The preparation process comprises the steps of weighing the radix angelicae sinensis, the cortex cinnamomi, the herba asari, the dried chilli and the herba menthae; performing distillation with steam, and extracting volatile oil for later use; weighing theherba cynomorii, the caulis akebiae and the radix paeoniae alba, combining the theherba cynomorii, the caulis akebiae and the radix paeoniae alba with traditional Chinese medicine residues in the step 2, decocting the combined materials with water, and extracting herbal soup for later use; weighing the cupparis spinosa, crushing the cupparis spinosa, extracting a cupparis spinosa extracting solution, preparing a thick extract from the extracted cupparis spinosa extracting solution and the decocted herbal soup, mixing the thick extract with a blank matrix, adding the extracted volatile oil, and performing stirring. The traditional Chinese medicine preparation is quick-acting, free oftoxic and side effects and capable of treating both symptoms and root causes.

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a preparation method of a pharmaceutical composition for treating osteoarthrosis. According to the preparation method disclosed by the invention, the pharmaceutical composition is prepared from rhizoma cibotii, herba epimedii, radix angelicae pubescentis, drynaria rhizome, teasel root, parasitic loranthus, caulis spatholobi, prepared rehmannia root, elecampane, and processed products of olibanum volatile oil, myrrh essential oil and fructus psoraleae as medicines. The pharmaceutical composition prepared by the method is capable of effectively treating osteoarthritis and lumbar muscle degeneration caused by deficiency of the liver and kidneys, qi-stagnation and blood stasis, and vein stagnation, is capable of effectively reducing hepatic toxic side effects of original products, and has relatively good clinical treatment effects.

The invention provides an oral preparation for preventing and treating osteoarthrosis and a preparation method thereof, and the oral preparation is prepared from active components and pharmaceutic adjuvants. The active components are prepared from the following traditional Chinese medicinal raw materials in parts by weight: agkistrodon halys, zaocys dhumnade, oyster, medlar, donkey-hide gelatin, sea cucumber, pawpaw, prepared rehmannia root, epimedium, cibotium barometz, radix aconiti lateralis preparata, antler piece, eucommia ulmoides, cassia twig, angelica sinensis, ligusticum wallichii, ground beeltle, notopterygium root, mint, kudzu vine root, myrrh, chrysanthemum, ephedra, fructus forsythiae, lycopodium clavatum, radix angelicae pubescentis, cortex moutan, dried ginger, willow branch, pericarpium zanthoxyli, eucommia ulmoides, allium macrostemon, polygonum cuspidatum, corn stigma and dandelion; the agkistrodon halys and the zaocys dhumnade have the functions of dispelling wind and eliminating dampness, dredging tendons and activating collaterals, dissipating blood stasis and relieving pain, and strengthening body and bone, can be used for treating diseases such as rheumatic arthralgia, waist and knee pain, numbness of limbs, hemiplegia, traumatic injury and the like, has a remarkable treatment effect on osteoarthropathy, and can obviously relieve pain caused by the osteoarthropathy.

The invention is directed to a compound of the formula I wherein the variables are as defined herein, or a stereoisomeric form thereof, mixture of stereoisomeric forms, in any ratio, or a salt thereof. Another aspect of the present invention is directed to a pharmaceutical composition comprising, a pharmaceutically effective amount of one or more compounds of formula I according to claim 1 in admixture with a pharmaceutically acceptable carrier. The invention is also directed to a method for effecting the prophylaxis and therapy of degenerative joint diseases such as osteoarthroses, spondyloses, cartilage loss following joint trauma or a relatively long period of joint immobilization following meniscus or patella injuries or ligament ruptures, diseases of the connective tissue such as collagenoses, periodontal diseases, wound healing disturbances and chronic diseases of the locomotory apparatus such as inflammatory, immunological or metabolism-associated acute and chronic arthritides, arthropathies, myalgias and disturbances of bone metabolism, for the treatment of ulceration, atheroscleroses and stenoses, and for the treatment of inflammations, cancer diseases, tumor metastasis formation, cachexia, anorexia, cardiac insufficiency and septic shock or for the prophylaxis of myocardial and cerebral infarctions, in a patient in need thereof, comprising administering to the patient a pharmaceutically effective amount of the compound of formula I according to claim 1, or a pharmaceutically acceptable salt, solvate or prodrug thereof. Furthermore the invention is directed to a method for preparing a compound of formula I.

The invention discloses a snake original peptide extracting device and a method thereof, which belong to the field of extraction of snake original peptide. The invention provides the snake original peptide extracting device and the method thereof, the snake original peptide extracting device has the advantages of improving the yield of the snake peptide, increasing the proportion of the natural polypeptide in the snake peptide, and increasing the activity and the like; and can reduce the process time and reduce the production cost. The snake original peptide has main functions of dispelling wind, relaxing vein and arresting convulsion. The snake original peptide has the treatment of rheumatism, regulation of sebum secretion, regulation of blood lipids, regulation of immunity, and regulation of endocrine, so that the condition of patients with arthritis and osteoarthrosis tends to be stable. The snake original peptide can lighten spots, eliminate acne, relieve itching and care skin, andtreat rheumatism, skin numbness, and arteriospasm, is especially suitable for the patients who are paralyzed for a long time, and greatly reduces the waste of the snake propeptide in the preparationprocess by optimizing the process flow. the yield is increased, and the pre-treatment can effectively reduce the waste in the preparation process.

The invention provides medical chitosan for articular cavity injection and a preparation method thereof, the material is prepared from carboxymethyl chitin and equilibrium liquid, the appearance is colorless and transparent viscous liquid, the medical chitosan is directly filled into an injector after being prepared, and then terminal sterilization is performed to obtain the medical chitosan. The terminal sterilization adopts terminal high-temperature moist heat sterilization, the equilibrium liquid is prepared from sodium chloride, sodium dihydrogen phosphate and disodium hydrogen phosphate according to a certain proportion, the main component of the material is polyglucosamine, and the material has viscoelasticity and slow absorbability and can be used for intra-articular injection; as a lubricant in a bone joint, the lubricant is used for lubricating the joint, protecting articular cartilage and assisting in treatment of osteoarthrosis.

The invention provides a pharmaceutical composition for treating osteoarthrosis. The composition is composed of a variety of traditional Chinese medicines that mainly have kidney-tonifying functions, cold-dispelling functions, heat-clearing functions, stasis-removing and dampness-removing functions, wind-dispelling functions, and blood-activating functions. . The pharmaceutical composition can also be prepared into medicinal wine for use. The pharmaceutical composition and medicinal wine of the present invention can activate blood circulation and remove blood stasis, reduce swelling and relieve pain, relax meridians and activate collaterals. They have significant anti-inflammatory effects, protect bone and joint structures, promote bone growth and healing, etc., and are suitable for bruises, rheumatoid arthritis, and similar diseases. It has excellent clinical effects on bone and joint diseases such as rheumatoid arthritis.

The present invention relates to a sulfonyl acetylglucosamine medicine composition and its application in preparation of medicine for curing retrograde osteoarthropathy. Said medicine composition is formed from 1-90% of sulfonyl acetylglucosamine, 90-1% of acetylglucosamine and 1-10% of hydroxylysine. Said invented oral preparation or fluid infusion preparation has the notable therapeutical effect for curing the diseases of senile osteoarthropathy, scapulohumeral periarthritis, articular cartilage synovial injury by collision, cartilage synovial injury and chondronecrosis of head of femur, cartilaginous synvium restoration of rheumatoid arthritis in stable stage and fatigue osteoarthritis, etc.

The invention discloses a laser rehabilitation treatment device for primary osteoarthropathy lesions. The device comprises a power module (1), a controller (2), a laser irradiation module (3) and a temperature measurement module (4); the laser irradiation module is a laser emission unit which emits near-infrared laser beams with different wavelengths in both pulsed and continuous-wave working modes. Beneficial effects: the invention apply near-infrared pulsed laser and continuous-wave laser with two kinds of wavelengths to knee joint capsules; the pulsed laser multipoint irradiation stimulatesmeniscus to promote the secretion of joint capsule lubricating fluid and the absorption of seepage fluid; and the invention acts on the small joint capsules at the far end of the limbs to promote theabsorption of urate. The continuous-wave laser uniform irradiation forms heat radiation to the lesion areas, and promotes circulation, thereby realizing the rehabilitation therapy for the primary osteoarthropathy lesions.

The present invention relates to an externally applied drug for the treatment of lumbar, cervical and bone joint diseases, which is characterized in that the present invention is prepared by the pharmaceutical raw materials with the following mix ratio by weight: 25 to 35 parts of Szechuan lovage rhizome, 20 to 30 parts of Chinese angelica, 35 to 45 parts of peach seed, 20 to 30 parts of safflower, 15 to 25 parts of sappan wood, 15 to 25 parts of cape jasmine fruit, 15 to 25 parts of nutgrass galingale rhizome, 15 to 25 parts of pangolin scales, 30 to 40 parts of leech, 1 to 3 parts of musk, 25 to 35 parts of dragon's blood, 20 to 30 parts of frankincense, 20 to 30 parts of myrrh, 15 to 25 parts of trogopterus dung, 15 to 25 parts of incised notopterygium rhizome, 15 to 25 parts of doubleteeth pubescent angilica root, 20 to 30 parts of pedate pinallia jackinthepulpit rhizome, 25 to 35 parts of scorpion, 15 to 25 parts of manchurian wildginger, 30 to 40 parts of dahurian angelica root, 25 to 35 parts of divaricate saposhnikovia root, 15 to 25 parts of great burdock achene, 20 to 30 parts of dried ginger, 25 to 35 parts of kusnezoff monkshood root, 25 to 35 parts of common monkshood mother root, 15 to 25 parts of pine nodular branch, 15 to 25 parts of siberian cocklour fruit, 20 to 30 parts of snake slough, 20 to 30 parts of tall gastrodia tuber, 30 to 40 parts of realgar, 35 to 45 parts of common floweringquince fruit, 15 to 25 parts of seaweed, 15 to 25 parts of kelp, 20 to 30 parts of lilac daphne flower bud, 20 to 30 parts of Peking euphorbia root, 25 to 35 parts of cochinchina momordica seed, 25 to 35 parts of Gleditsia sinensis stings, 25 to 35 parts of ephedra herb, 55 to 65 parts of hydrargyri oxydum rubrum, 10 to 20 parts of borax and 10 to 20 parts of borneol.

The invention belongs to the technical field of medicines, and particularly relates to an arthralgia-relieving and bone-nourishing fumigation and application prescription. The prescription is preparedfrom the following traditional Chinese medicine raw materials in parts by weight: 150 to 250 parts of folium artemisiae argyi, 150 to 250 parts of eucommia ulmoides, 150 to 250 parts of uncaria laevigata, 150 to 250 parts of common clubmoss herb, 150 to 250 parts of tripterygium wilfordii, 150 to 250 parts of garden balsam stems, 150 to 250 parts of pinus tabulaeformis knots, 150 to 250 parts oflilac, 150 to 250 parts of trident maple, 150 to 250 parts of alangium platanifolium, 150 to 250 parts of colquhounia coc cinea, 100 to 200 parts of sargentgloryvine stems, 100 to 200 parts of akebiastems, 100 to 200 parts of pseudo-ginseng leaves, 100 to 200 parts of stems of climbing entada, 150 to 250 parts of suberect spatholobus stems, 150 to 250 parts of pawpaw, 100 to 200 parts of long pepper and 100 to 200 parts of herba taxilli. The prescription has the total effects of expelling wind and removing cold, removing dampness, clearing and activating the channels and collaterals, clearingaway heat and toxic materials, eliminating swelling and resolving masses, warming and harmonizing the middle warmer and invigorating the stomach. The prescription is mainly used for treating rheumatic bone diseases (rheumatic osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, femoral head necrosis, lumbar disc herniation (swelling), gout and dandruff skin diseases), degenerative osteoarthropathy and the like, and has an effective rate of as high as 93.4%.

Disclosed is a pharmaceutical composition having improved stability comprising an extract of a natural product, in which the content of an active ingredient in the extract is stably maintained by adding only a small amount of an additive to an extract of a whole plant of Chrysanthemum indicum or a related plant of the same genus, and the stability of the extract is improved. The extract is effective for preventing and treating osteoarthropathy and the like but is susceptible to moisture, and the pharmaceutical composition can ensure various stability with respect to moisture and the like when formulated into a drug. The pharmaceutical composition having improved stability comprising a natural product extract comprises particles of a Chrysanthemum indicum extract obtained by mixing the Chrysanthemum indicum extract and a dextrin-based compound and granulating the mixture.

The invention discloses an arthritis-relieving dropping pill for treating osteoarthrosis and a preparation process of the dropping pill. The dropping pill is prepared from refined extract of traditional Chinese medicinal materials with doses, polyethylene glycol substrate and other auxiliaries, wherein the weight part ratio of the refined extract to the polyethylene glycol substrate to the other auxiliaries is 20-60 to 20-100 to 0-5; the refined extract comprises two parts of components; one part of component is prepared by steam distillation or supercritical extraction, while the other part is prepared by extracting with ethanol, water or mixed solvent of water and ethanol. The taking dose of the arthritis-relieving dropping pill is low, so that the dropping pill can be easily accepted and taken by a patient, and the dropping pill has the characteristics of quick dissolving speed, facilitation in body absorption, and stable quality.

The invention belongs to the field of medical treatment, in particular to a small needle knife structure for treating osteoarthritis. The existing small needle knife cannot replace the needle bar according to the usage situation, and the use is not convenient enough, and the use effect is not good. The problem is that it includes a knife handle and a needle bar. Both sides of the upper end of the knife handle are fixedly installed with a connecting plate, and a light tube is fixedly installed on one side of the outer surface of the knife handle at the lower end of the connecting plate. A connecting seat is fixedly installed in the middle of the lower end of the handle, a knife head is fixedly connected to the lower end of the needle bar, a scale bar is carved on the outer surface of the needle bar, and a laser lamp body is fixedly installed at the inner front end of the lamp tube. The present invention can quickly and conveniently replace the needle bar according to the use situation, making the use of the small needle knife more convenient, and can be illuminated by a laser light when in use, which is convenient for the use of the small needle knife, and can also improve the accuracy of the use of the small needle knife .