Compound metronidazole tablet for pets, and preparation method of compound metronidazole tablet

A technology of compound metronidazole tablet and metronidazole, which is applied in the field of animal medicine, can solve the problems of pet clinical medication inconvenience and unsatisfactory effect, and achieve the effect of high safety, quality and safety, and reduce difficulties

Inactive Publication Date: 2021-09-07
JIANGSU HFQ BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, in the pet medical industry, most commonly used commercial drugs for treating periodontal diseases in pets are mostly administered orally, such as metronidazole tablets for anti-anaerobic bacteria, or amoxicillin tablets for anti-inflamma

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Pretreatment of raw and auxiliary materials

[0026] The raw materials of metronidazole and fenbufen are pulverized through an 80-mesh sieve, cornstarch and sucrose are passed through a 40-mesh sieve, and carboxymethyl starch sodium, carboxymethylcellulose sodium and magnesium stearate are passed through a 60-mesh sieve for later use.

[0027] (2) wet granulation

[0028] Get 20 parts of crushed and sieved metronidazole, 15 parts of fenbufen, 30 parts of cornstarch, 10 parts of sucrose, 5 parts of sodium carboxymethyl starch, 2 parts of 2% sodium carboxymethyl cellulose aqueous solution, 5 parts of beef essence parts, mix evenly, add water to make soft material, wet granulation

[0029] (3) Drying and granulation

[0030] After the wet granules are dried, pass through a 20-mesh sieve for sizing, add 0.5 parts of magnesium stearate and mix them uniformly in a mixer to obtain intermediate granules

[0031] (4) Tablet

[0032] The intermediate granules are compress...

Embodiment 2

[0034] (1) Pretreatment of raw and auxiliary materials

[0035] The raw materials of metronidazole and fenbufen are crushed through an 80-mesh sieve, microcrystalline cellulose is passed through a 40-mesh sieve, and dry starch, low-substituted hypromellose and micropowdered silica gel are passed through a 60-mesh sieve for later use.

[0036] (2) wet granulation

[0037] Take 20 parts of crushed and sieved metronidazole, 15 parts of fenbufen, 50 parts of microcrystalline cellulose, 7 parts of dry starch, 1 part of 2% low-substituted hypromellose aqueous solution, and 10 parts of yeast extract. Uniform, add water to make soft material, wet granulation

[0038] (3) Drying and granulation

[0039] After the wet granules are dried, pass through a 40-mesh sieve for sizing, add 1 part of micropowder silica gel and mix them evenly in a mixer to obtain intermediate granules

[0040] (4) Tablet

[0041] The intermediate granules are compressed and packaged to obtain metronidazole f...

Embodiment 3

[0043] (1) Pretreatment of raw and auxiliary materials

[0044] The raw materials of metronidazole and fenbufen are crushed through an 80-mesh sieve, microcrystalline cellulose and dextrin are passed through a 40-mesh sieve, and dry starch, low-substituted hypromellose and micropowder silica gel are passed through a 60-mesh sieve for later use.

[0045] (2) wet granulation

[0046] Get 20 parts of crushed and sieved metronidazole, 15 parts of fenbufen, 40 parts of microcrystalline cellulose, 10 parts of dextrin, 3 parts of crospovidone, 2.5 parts of 1% polyvinylpyrrolidone, 8 parts of chicken essence Mix evenly, add water to make soft material, wet granulation

[0047] (3) Drying and granulation

[0048] After the wet granules are dried, pass through a 20-mesh sieve for sizing, add 1.5 parts of talcum powder and mix them evenly in a mixer to obtain intermediate granules

[0049] (4) Tablet

[0050] The intermediate granules are compressed and packaged to obtain metronidazo...

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PUM

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Abstract

The invention discloses a compound metronidazole tablet for pets, and a preparation method of the compound metronidazole tablet. The compound metronidazole tablet mainly comprises the following components in parts by weight: 20 parts of metronidazole, 15 parts of fenbufen, 40-60 parts of diluent, 3-10 parts of disintegrating agents, 2-5 parts of adhesives, 5-15 parts of phagostimulant and 0.25-2.0 parts of lubricants. The compound metronidazole tablet is suitable for the periodontal diseases, including gingivitis, periodontitis, gingival abscess, acute dental infection caused by clostridium and the like, of pets, has a good prevention and treatment effect and safe quality, is convenient for clinical medication of the pets, and has a good curative effect for the periodontal diseases caused by anaerobic infection of pets. After being used, the compound metronidazole tablet is good in oral absorption, and the bioavailability is 80% or above.

Description

technical field [0001] The invention relates to the technical field of animal medicine, in particular to a compound metronidazole tablet for pets and a preparation method thereof. Background technique [0002] Periodontal disease is one of the common diseases in dogs and cats. It is an acute or chronic inflammation of the periodontal ligament and its surrounding tissues. It begins with gingivitis and progresses to periodontitis. When the condition is severe, it can be seen that the alveolar bone is absorbed, the teeth are loose and the gums are atrophied. The lesions are usually generalized except when confined to a single tooth. Data show that the incidence of periodontal disease in dogs and cats over 5 years old is 80%. Many clinicians have found that dogs over 3 years old often have different degrees of periodontal disease when they open their mouths, so it is worthy of great attention from pet owners. [0003] At the time of the onset, dogs have residual food or fore...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4164A61K31/192A61P1/02A61P31/02A61P31/04A61P29/00
CPCA61K9/2059A61K9/2068A61K31/4164A61K31/192A61P1/02A61P31/02A61P31/04A61P29/00A61K2300/00
Inventor 廖洪武慧芳郭春燕
Owner JIANGSU HFQ BIO TECH CO LTD
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