Composition with anti-constipation effect, preparation method and application thereof

Abstract

The invention relates to a composition with a constipation prevention and treatment effect, and a preparation method and an application thereof. Effective components in the composition are a first polymer and a second polymer, wherein the first polymer and the second polymer are obtained through glycosidic bond polymerization of monosaccharide and / or uronic acid of monosaccharide, the polymerization degree of the first polymer is an integer of 2-100, the polymerization degree of the second polymer is an integer of 10-3000, and the mass ratio of the first polymer to the second polymer is 1:3-1:6. The composition disclosed by the invention is suitable for tumor-associated diarrhea, has a bidirectional regulation effect on constipation and diarrhea, and can be taken for a long time.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a composition with the effect of preventing and treating constipation, a preparation method thereof and an application thereof. Background technique [0002] Constipation is a common digestive system disease. Normal people defecate 1-2 times a day or once every 1-2 days. Constipation patients often show symptoms such as induration of stool, difficulty in defecation, laborious defecation, incomplete defecation, induration and small amount of stool, and decreased frequency of defecation (≤3 times / week). Surveys show that constipation can occur in people of any age and any occupation, and the incidence rate of constipation is as high as 20%-30% (Wang Jiyao. Internal Medicine [M]. 2nd Edition. Beijing: People's Medical Publishing House, 2011:479.). [0003] Constipation is one of the common complications of cancer patients. About 40% of end-stage cancer patients will experience constipa...

AI Technical Summary

Problems solved by technology

[0023] At present, the commercially available compositions with the effect of preventing and treating constipation have the following defects: (1) inulin causes a higher incidence of abdominal distension in users who take them; It can play a role in regulating the balance of intestinal flora, and has a high incidence of abdominal distension; (3) Lactulose is converted into low molecular weight organic acids by the digestive tract flora in the colon, resulting in a decrease in the pH value of the intestinal tract and increasing gas production in patients After taking it, it is easy to have adverse reactions such as flatulence and abdominal discomfort

This product has the following defects: First, the product combines inulin, fructooligosaccharides, polydextrose, xanthan gum and other ingredients, the product ingredients are complex, and there is no targeted selection of dietary fiber ratios suitable for different constipation groups , the preparation cost is relatively high; the second is that inulin is a linear straight-chain polysaccharide formed by fructose linked by β(2-1) bonds, often with a glucose at the end, and the degree of polymerization is usually 2-60

This product has two major defects: one is that it needs to be used together with dairy products (such as milk, lactic acid beverages, formula milk powder, cheese, etc.), and patients with organic constipation often show intolerance to dairy products, resulting in a high incidence of abdominal distension The second is that the dietary fiber content in the product is low, which is not conducive to improving gastrointestinal motility, and the effect of improving constipation is limited.

[0026] Currently, the marketed constipation treatment drugs or compositions have the following defects: (1) limited indications, many application contraindications, limited applicable population and application methods, especially not suitable for patients with tumor-related constipation; (2) not easily (3) The content of dietary fiber is insufficient, it is difficult to meet the clinical needs of enhancing gastrointestinal motility of patients, and it is prone to repeated constipation symptoms; (4) The product does not effectively improve the composition and balance of intestinal flora (5) The lactulose contained in the product is converted into low-molecular-weight organic acids by the digestive tract flora in the colon, which leads to a decrease in the pH value of the intestinal tract and increases the frequency of gas production in patients. Cause adverse reactions such as flatulence and abdominal discomfort in the users; (6) Poor clarity of the product, which affects the appearance and taste of the product, and affects the patient's compliance with taking it

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