The invention discloses a dentritic
heparin nano-material and a modified biological type artificial
blood vessel. The dentritic
heparin nano-material provided by the invention has a terminal
branch unit shown in formula I, and is obtained by a reaction between polyamidoaminedendrimers using
hydrazide group as a terminal group and
heparin, wherein the inner core of the polyamidoaminedendrimers is
cystamine, and the dentritic frame of the polyamidoamine dendrimers is
hydrazide modified polyamidoamine including -0.5, 0.5, 1.5, 2.5, 3.5, 4.5, 5.5, 6.5 and 7.5; and the connection between the heparin and polyamidoamine is a
glycosidic bond formed a reaction between the
hydrazide on the surface of the polyamidoamine and the heparin reducing terminal. The
disulfide bond in the dentritic heparin nano-material is
cut through a
reducing agent to obtain a sulfydryl site which can react with an
intravascular stent material; and the surface in a
blood vessel can be activated through a
coupling agent of a two-way functional group, and the heparin with a
branch structure can be fixed on the inner surface of the
blood vessel material through
chemical bond covalence, so that a composite artificial blood vessel with an anticoagulation effect can be obtained.