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Lactobacillus paracasei L9 with effect of relieving constipation of people and application thereof

A paracheese and lactobacillus technology, applied in the field of microorganisms, to achieve the effects of improving constipation-related symptoms, improving stool shape, and relieving constipation

Pending Publication Date: 2019-08-23
北京和益源生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of existing research and existing problems, the purpose of the present invention is to provide a kind of Lactobacillus paracasei L9 and its application with the effect of improving people's constipation

Method used

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  • Lactobacillus paracasei L9 with effect of relieving constipation of people and application thereof
  • Lactobacillus paracasei L9 with effect of relieving constipation of people and application thereof
  • Lactobacillus paracasei L9 with effect of relieving constipation of people and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] This embodiment provides a fermented dairy product for improving constipation. The preparation method is as follows:

[0019] 70% skimmed milk+15% sucrose+15% glucose→heat up to 65℃→20MPa homogenization→packaging→browning (temperature>95℃6-7h)→cool to room temperature→after 10 2 -10 4 CFU / g inoculation amount of Lactobacillus paracasei L9→37℃ fermentation for 78h→demulsification→mixing→homogenization→packing→storage.

[0020] In order to test the relieving effect of the fermented dairy products in this example on the symptoms of constipation, the following human tests were carried out:

[0021] The experiment recruited 62 patients with constipation who met the Rome III criteria. The subjects will enter the baseline period from day 0 to day 13. During the emptying period, the subjects continued their normal diet, but could not consume other fermented dairy products. On day 14 the subject was required to give the researcher a complete log during the baseline period. Collect a ...

Embodiment 2

[0029] This embodiment provides a room temperature yogurt for improving constipation. The raw materials include 90% raw milk, 7% white sugar, 3% whey protein powder, and fermentation of Lactobacillus paracasei L9.

[0030] Standardization of 90% raw milk → detection → 7% white sugar + 3% whey protein powder mixed ingredients → homogenization → sterilization → cooling to room temperature → 10 2 -10 4 CFU / g inoculation amount of Lactobacillus paracasei L9→37℃ fermentation for 78h→sterilization→cooling and packaging→storage.

[0031] In order to test the relieving effect of the room temperature yogurt in this example on the symptoms of constipation, the following human test was performed:

[0032] The experiment recruited 60 constipation patients who met the Rome III criteria, and the subjects would enter the baseline period from day 0 to day 13. During the emptying period, the subjects continued their normal diet, but could not consume other fermented dairy products. On day 14 the sub...

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Abstract

The invention discloses a lactobacillus paracasei L9 with the effect of relieving constipation of people and application thereof. The lactobacillus paracasei L9 is preserved at the China General Microbiological Culture Collection Center on October 22, 2014, and the preservation number is CGMCC. NO. 9800. The lactobacillus paracasei L9 can be used for preparing pharmaceutical compositions or food for treating or preventing constipation, and studies have confirmed that the active lactobacillus paracasei, the inactivated lactobacillus paracasei and derivatives thereof all have the function of relieving constipation of people. It is found by studies that by drinking fermented milk and normal-temperature yogurt both of which contain lactobacillus paracasei L9, symptoms related to constipation can be effectively relieved, the defecation frequency is increased, and the shape of feces is improved, so that it is indicated that lactobacillus paracasei L9 can effectively alleviate constipation ofthe Chinese population.

Description

Technical field [0001] The invention belongs to the technical field of microorganisms, and particularly relates to a Lactobacillus paracasei L9 with the effect of improving human constipation and its application. Background technique [0002] Lactobacillus paracasei is a kind of probiotic lactic acid bacteria that has been studied abroad in recent years. It is widely present in traditional fermented dairy products and human gastrointestinal tract. A large amount of data has shown that Lactobacillus paracasei has very broad development and application prospects in the field of probiotics. At present, research results have confirmed that Lactobacillus paracasei has the following probiotic functions: (1) Antibacterial effect. It is reported that Lactobacillus paracasei has an inhibitory effect on some pathogenic bacteria in food and intestinal tract, and the bacteriostatic substance produced by its fermentation has an inhibitory effect on Gram-positive and negative bacteria and a v...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20A61K35/747A61P1/10A23L33/135C12R1/225
CPCA61K35/747A61P1/10A23L33/135A23V2002/00C12R2001/225C12N1/205A23V2400/165A23V2200/3204
Inventor 葛绍阳刘治麟张静
Owner 北京和益源生物技术有限公司
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