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Use of orlistat in preparing medicine for treating constipation

An orlistat, a technology for treating constipation, applied in the field of medicine, can solve the problems of low solubility, unpublished, high viscosity, and achieve the effects of reducing oil spots and improving constipation symptoms

Active Publication Date: 2019-02-26
ZHONGSHAN WANHAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high molecular weight, high viscosity and low solubility of natural KGM, its application is greatly limited. At present, natural KGM is mainly degraded by chemical or biological modification methods to obtain different molecular weights and different physical and chemical properties. Konjac glucomannan oligosaccharides (KOGM) with biological functions, and KOGM with different molecular weights have significant differences in physicochemical and biological functions
The combination of konjac glucomannan and orlistat as a drug for treating constipation has not yet been disclosed.

Method used

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  • Use of orlistat in preparing medicine for treating constipation
  • Use of orlistat in preparing medicine for treating constipation
  • Use of orlistat in preparing medicine for treating constipation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1. Orlistat and Konjac Glucomannan Oligosaccharide Tablets

[0030] Party 1:

[0031] ingredient

Dosage (g / piece)

Orlistat

0.045g

Konjac Glucomannan Oligosaccharide

0.45g

Microcrystalline cellulose

1.365g

Sodium dodecyl sulfate

0.18g

Sodium starch glycolate

0.36g

Polyvinylpyrrolidone

0.3g

Magnesium stearate

0.3g

total

3.0g

[0032] Among them, the konjac glucomannan oligosaccharide is composed of 12wt% KOGM-1, 65wt% KOGM-2 and 23wt% KOGM-3.

[0033] Party 2:

[0034] ingredient

Dosage (g / piece)

Orlistat

0.105g

Konjac Glucomannan Oligosaccharide

0.6g

Microcrystalline cellulose

1.2g

Sodium dodecyl sulfate

0.195g

Sodium starch glycolate

0.3g

Polyvinylpyrrolidone

0.3g

Magnesium stearate

0.3g

total

3.0g

[0035] Among them, the konjac glucomannan oligosaccharide is composed of 22wt% KOGM-1, 50wt% KOGM-2 and 28wt% KOGM-3.

[0036] Party 3:

[0037]

[0038]

[0039] Among them, konjac glucomannan oligosaccharide is composed of 8wt% KOGM-1, 60wt% KOGM-...

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PUM

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Abstract

The invention belongs to the medicine field and particularly relates to application of orlistat in preparation of drugs for curing constipation. The medicine comprises effective amount of orlistat andeffective amount of konjac glucomannan with different molecular weight, the medicine is formed by certain amount ratio of the konjac glucomannan and the orlistat, it is amazedly found that the medicine has remarkable effect for improving the constipation symptom, at the same time, oil stain and fatty excrement adverse reaction caused by orlistat taking can be effectively relieved, and compared with the prior art, remarkable improvement is obtained.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to the use of risstat in preparing a medicine for treating constipation. Background technique [0002] Orlistat is usually used as a new type of weight-loss drug and is the only non-central nervous weight-loss drug. It is a long-acting and potent specific gastrointestinal lipase inhibitor, which can interact with the stomach and small intestine. The active serine part of lipase and pancreatic lipase combines to form a covalent bond, which makes the lipase inactive, prevents the decomposition, absorption and utilization of fat in food, so as to achieve the goal of weight loss. [0003] Although orlistat has a significant effect on weight loss, there are also many adverse reactions that cannot be ignored. Common adverse reactions include oily spots, urgency to defecate, oily spots, increased gastrointestinal gas, fatty stools, Increase bowel movements and incontinence. Among them, the ad...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K47/36A61P1/10
CPCA61K31/365A61K47/36A61P1/10
Inventor 杜志博向飞彭韪
Owner ZHONGSHAN WANHAN PHARM CO LTD
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