Methods and compositions for the treatment of gastrointestinal disorders

a technology for gastrointestinal disorders and compositions, applied in the field of methods and compositions for the treatment of gastrointestinal disorders, can solve the problems of patients with ibs, tremendous unmet medical needs, and reduced quality of life of patients

Inactive Publication Date: 2007-01-11
IRONWOOD PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with IBS have three times more absenteeism from work and report a reduced quality of life.
There is a tremendous unmet medical need in this population since few prescription options exist

Method used

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  • Methods and compositions for the treatment of gastrointestinal disorders
  • Methods and compositions for the treatment of gastrointestinal disorders
  • Methods and compositions for the treatment of gastrointestinal disorders

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0209] The peptides of the invention bind to the guanylate cyclase (GC-C) receptor, a key regulator of fluid and electrolyte balance in the intestine and kidney. When stimulated, this receptor, which is located on the apical membrane of the intestinal epithelial surface, causes an increase in intestinal epithelial cyclic GMP (cGMP). This increase in cGMP is believed to cause a decrease in water and sodium absorption and an increase in chloride and potassium ion secretion, leading to changes in intestinal fluid and electrolyte transport and increased intestinal motility. The intestinal GC-C receptor possesses an extracellular ligand binding region, a transmembrane region, an intracellular protein kinase-like region and a cyclase catalytic domain. Proposed functions for the GC-C receptor are the fluid and electrolyte homeostasis, the regulation of epithelial cell proliferation and the induction of apoptosis (Shaibhubhai 2002 Curr Opin Drug Dis Devel 5:261-268).

[0210] In addition to b...

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Abstract

Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.

Description

[0001] This application is a continuation (and claims the benefit of priority under 35 USC 120) of U.S. application Ser. Nos. 60 / 478,492, filed Jun. 13, 2003, 60 / 532,361 filed Dec. 23, 2003 and 60 / 571,386 filed May 14, 2004 The disclosure of the prior applications is considered part of (and is incorporated by reference in) the disclosure of this application.TECHNICAL FIELD [0002] This invention relates to methods and compositions for treating gastrointestinal disorders, obesity, congestive heart failure, benign prostatic hyperplasia and other disorders. BACKGROUND [0003] Irritable bowel syndrome (IBS) is a common chronic disorder of the intestine that affects 20 to 60 million individuals in the US alone (Lehman Brothers, Global Healthcare-Irritable Bowel Syndrome Industry Update, September 1999). IBS is the most common disorder diagnosed by gastroenterologists (28% of patients examined) and accounts for 12% of visits to primary care physicians (Camilleri 2001 Gastroenterology 120:65...

Claims

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Application Information

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IPC IPC(8): A61K38/10C07K7/08A61KA61K38/00A61K38/02C07K2/00
CPCC07K7/08A61K38/00A61P1/00A61P1/02A61P1/04A61P1/10A61P1/14A61P3/04A61P9/04A61P13/08A61P29/00A61P35/00A61P35/02A61P35/04A61P43/00
Inventor CURRIE, MARK G.MAHAJAN-MIKLOS, SHALINASUN, LI JING
Owner IRONWOOD PHARMA
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