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Application of lactobacillus casei and ginkgo leaf extract in preparing medicine used for controlling hyperlipidemia

A technology of Lactobacillus casei and hyperlipidemia, which is applied to the application field of Lactobacillus casei and Ginkgo biloba extract in the preparation of drugs for preventing and treating hyperlipidemia, and can solve the problems such as no comparison and combined effect yet.

Inactive Publication Date: 2013-07-31
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is no report on the comparison and joint effect of the two

Method used

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  • Application of lactobacillus casei and ginkgo leaf extract in preparing medicine used for controlling hyperlipidemia
  • Application of lactobacillus casei and ginkgo leaf extract in preparing medicine used for controlling hyperlipidemia
  • Application of lactobacillus casei and ginkgo leaf extract in preparing medicine used for controlling hyperlipidemia

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Embodiment Construction

[0011] The present invention will be described in detail below in conjunction with specific embodiments.

[0012] 1 Materials and methods

[0013] 1.1 Materials

[0014] Ginkgo biloba active ingredient extract (purchased from Sichuan Tongtai Plant Chemical Co., Ltd.), Lactobacillus casei K1 strain (Lactobacillus casei subsp. No. 13, Zhongguancun Beiyiyiyi, Institute of Microbiology, Chinese Academy of Sciences), number: CGMCC1.2435), 60 experimental mice (60 female mice from Longshujiajia, Sichuan Agricultural University, weighing 19-21g), MRS medium (peptone 10g, beef extract 5g, yeast extract powder 4g, glucose 20g, Tween-801ml, dipotassium hydrogen phosphate 2g, sodium acetate 5g, triammonium citrate 0.2g, magnesium phosphate 0.2g, manganese sulfate 0.05g), orally Needle.

[0015] 1.2 Instruments and equipment

[0016] Automatic biochemical analyzer GS200 (Shenzhen Jinrui Electronics Co., Ltd.), AL204 electronic balance (Mettler-Toledo Instruments Co., Ltd.).

[0017] ...

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Abstract

The invention discloses an application of lactobacillus casei and ginkgo leaf extract in preparing medicines used for controlling hyperlipidemia. With a synergetic effect of lactobacillus casei and ginkgo leaf extract, obese mice body mass, TC, TG and MDA are substantially reduced. Degradation rates of TC and TG are respectively improved by 24.48% and 20.93%; mice weight is reduced by 13.22% than a high-fat group; and MDA content is reduced by 5.98%. In mice serum, HDL-C is substantially increased, wherein an increasing rate reaches 167.85%. GSH-PX in mice body is increased by 13.14%. Activities of enzymes such as CAT and SOD are respectively reduced by 49.02% and 3.13%. With the synergetic effect of lactobacillus casei and ginkgo leaf extract, functions of blood fat reducing, cholesterol metabolism promoting, and weight controlling are provided. Therefore, lactobacillus casei and ginkgo leaf extract can be used in preventing and treating hyperlipidemia.

Description

technical field [0001] The invention relates to the application of Lactobacillus casei subspecies cheese and ginkgo leaf extract in the preparation of medicines for preventing and treating hyperlipidemia. Background technique [0002] In the 21st century, people's living standards have been significantly improved. At the same time, some lifestyle-related diseases have become the primary cause of threats to human health. The mortality rate of cardiovascular and cerebrovascular diseases in our country has risen to the second place. Hyperlipidemia, that is, the increase of serum total cholesterol, triglyceride, and low-density lipoprotein, is a major cause of cardiovascular and cerebrovascular diseases. A large number of epidemiological surveys and studies have shown that hyperlipidemia is a common disease in today's society. In recent years, its incidence has gradually increased, and it has been called "one of the three major killers of human health". The damage to human hea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P3/06A61K35/74A61K35/747
Inventor 曾东倪学勤温啸辛金鸽曾燕贺大方张丹丁艳东李利杰
Owner SICHUAN AGRI UNIV
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