Preparation method and use of Xanthoceras sobifoba kernel oil extracted from supercritical fluid and preparation of Xanthoceras sobifoba kernel oil

A technology of Xanthos sorbifolium seed oil and supercritical fluid, which is applied in the field of medicine, can solve the problems of protein denaturation in medicinal residues, large amount of organic solvents, and difficult recovery of solvents, etc., and achieves low cost, good processing characteristics, and practical value broad effect

Pending Publication Date: 2017-02-22
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oil extraction rate of the pressing method is low, and the unsaturated fatty acids in the oil are severely damaged under high-temperature pressing conditions, and it is easy to cause protein denaturation in the medicinal residues; the traditional organic solvent leaching method has a long production cycle, a large amount of organic solvent, and high production costs. The solvent is not easy to recycle, which will cause great damage to the operator's body and increase the pollution to the environment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Supercritical CO 2 Preparation of high-quality Xantho sorbifolia seed oil by fluid extraction and separation technology

[0015] Peel the radix sorbifolium seeds, get the radix sorbifolium seed kernels, dry at 50°C for 8 hours, control the water content to less than 8%, crush them, pass through a 60-mesh sieve, and put them into an extraction kettle. Extraction temperature 40°C, extraction pressure 28 Mpa, CO 2 The flow rate is 80 L / h, the temperature of the separation tank I is 35°C, the pressure of the separation tank I is 25 Mpa, the temperature of the separation tank II is 25°C, the pressure of the separation tank II is 8 Mpa, and the extraction time is 150min. Seed Kernel Oil. The remaining material in the extraction kettle is protein-rich Xanthos sorbifolium seed kernel drug residue, which can be used for extraction of total triterpenoid saponins. After the extraction, the oil content in the residue is less than 4%. The oil yield of the prepared sorbi...

Embodiment 2

[0016] Embodiment 2 One adopts supercritical CO 2 Method for preparing high-quality Xantho sorbifolia seed oil by fluid extraction and separation technology

[0017] Take 5 kg of fresh radix sorbifolium seeds, shell and separate the radix sorbifolium seed kernels, dry at 45°C for 10 h, control the water content to less than 6%, crush them, pass through a 30-mesh sieve, and put them into an extraction kettle. Extraction temperature 45°C, extraction pressure 35 Mpa, CO 2 The flow rate is 160 L / h, the temperature of the separation tank I is 40 °C, the pressure of the separation tank I is 10 MPa, the temperature of the separation tank II is 30 °C, the pressure of the separation tank II is 6 Mpa, and the extraction time is 120 min. Crown fruit seed oil. The remaining material in the extraction kettle is protein-rich Xanthos sorbifolium seed kernel drug residue, which can be used for the extraction of total triterpenoid saponins. After the extraction, the oil content in the residu...

Embodiment 3

[0018] Example 3 Preparation of Microcapsules of Xanthos sorbifolia Seed Kernel Oil by Emulsion Forming

[0019] The specific method steps are as follows:

[0020] 1. Using supercritical CO 2 Preparation of high-quality Xantho sorbifolia seed oil by fluid extraction and separation technology

[0021] 2. Preparation of the organic phase: Take an appropriate amount of Xantho sorbifolium seed oil, slowly add it to ethyl acetate under constant stirring at 30-120 rpm, ultrasonically stir to dissolve it evenly, and then add an appropriate amount of capsule material B to the solution Base cellulose, continue stirring until dissolved, and the resulting suspension is the organic phase;

[0022] 3. Preparation of water phase: Add a certain amount of ethyl acetate into distilled water at room temperature to form an aqueous solution saturated with ethyl acetate, then add an appropriate amount of Tween-80 to it, and stir at 30-120 rpm homogeneous water phase;

[0023] 4. Emulsification...

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PUM

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Abstract

The invention relates to a preparation method and use of Xanthoceras sobifoba kernel oil extracted from supercritical fluid and a preparation of the Xanthoceras sobifoba kernel oil. The preparation method comprises the steps of grinding Xanthoceras sobifoba kernels, sieving by virtue of a 10-100-mesh sieve, and carrying out supercritical fluid extraction in an extraction kettle, so as to obtain the Xanthoceras sobifoba kernel oil and a kernel residue rich in proteins, wherein the kernel residue can be used for extracting total saponins and has an extremely high medical value. Compared with a traditional squeezing process, a CO2 supercritical fluid extraction method has the advantages that the process is simple, the production cycle is short, the extraction efficiency is high, and the serious damage of unsaturated fatty acid in grease and the denaturationof the proteins in medicine residues at the high temperature are avoided. Compared with a method for extracting by virtue of organic solvents such as petroleum ether, the CO2 supercritical fluid extraction method has the advantages that the residual solvent is avoided, operation condition are mild, and the production is safe, toxic free and environmentally friendly. The oil extraction rate of the Xanthoceras sobifoba kernels is not lower than 50%, and GC-MS detection shows that the content of unsaturated fatty acid reaches up to 75% or above. By adding medical auxiliary materials, the dose forms of soft capsules, micro-capsules, cyclodextrin coated preparations, dripping pills and the like can be prepared and can be used for developing health products for preventing and treating hypertension, hyperlipemia and diseases of cardiovascular systems.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a preparation method and application of supercritical fluid extraction of Xantho sorbifolium seed oil and its preparation. Background technique [0002] Xanthoceras sorbifoBa Bunge is a Sapindaceae (Sapindaceae) Xanthoceras species. It is an excellent tree species for windbreak and sand fixation, water and soil conservation and landscaping. It is mainly distributed in Liaoning, Jilin, Hebei, Shandong, Gansu, northern China. Ningxia, Inner Mongolia, Shanxi, Henan and other provinces. It is recorded in "Chinese Ethnic Medicines" that the seed kernel of Xanthomonas radix is ​​a traditional medicinal material of the Mongolian nationality. Incontinence, mental retardation in children, senile dementia, Parkinson's syndrome and other diseases [Institute for the Control of Pharmaceutical and Biological Products of the Ministry of Health, Chinese National Pharmaceutical Journal, People's ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B1/10C11B1/04A61K9/20A61K9/48A61K9/50A61K36/77A61K47/69A61P3/10A61P9/12A61P3/06A61P9/00
CPCA61K9/2031A61K9/4816A61K9/5057A61K36/77A61K2236/37C11B1/04C11B1/104C11B1/108
Inventor 刘欣孙鹏刘彦臣刘君
Owner HARBIN UNIV OF SCI & TECH
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