Preparation method and use of Xanthoceras sobifoba kernel oil extracted from supercritical fluid and preparation of Xanthoceras sobifoba kernel oil

Abstract

The invention relates to a preparation method and use of Xanthoceras sobifoba kernel oil extracted from supercritical fluid and a preparation of the Xanthoceras sobifoba kernel oil. The preparation method comprises the steps of grinding Xanthoceras sobifoba kernels, sieving by virtue of a 10-100-mesh sieve, and carrying out supercritical fluid extraction in an extraction kettle, so as to obtain the Xanthoceras sobifoba kernel oil and a kernel residue rich in proteins, wherein the kernel residue can be used for extracting total saponins and has an extremely high medical value. Compared with a traditional squeezing process, a CO2 supercritical fluid extraction method has the advantages that the process is simple, the production cycle is short, the extraction efficiency is high, and the serious damage of unsaturated fatty acid in grease and the denaturationof the proteins in medicine residues at the high temperature are avoided. Compared with a method for extracting by virtue of organic solvents such as petroleum ether, the CO2 supercritical fluid extraction method has the advantages that the residual solvent is avoided, operation condition are mild, and the production is safe, toxic free and environmentally friendly. The oil extraction rate of the Xanthoceras sobifoba kernels is not lower than 50%, and GC-MS detection shows that the content of unsaturated fatty acid reaches up to 75% or above. By adding medical auxiliary materials, the dose forms of soft capsules, micro-capsules, cyclodextrin coated preparations, dripping pills and the like can be prepared and can be used for developing health products for preventing and treating hypertension, hyperlipemia and diseases of cardiovascular systems.

Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a preparation method and application of supercritical fluid extraction of Xantho sorbifolium seed oil and its preparation. Background technique

[0002] Xanthoceras sorbifoBa Bunge is a Sapindaceae (Sapindaceae) Xanthoceras species. It is an excellent tree species for windbreak and sand fixation, water and soil conservation and landscaping. It is mainly distributed in Liaoning, Jilin, Hebei, Shandong, Gansu, northern China. Ningxia, Inner Mongolia, Shanxi, Henan and other provinces. It is recorded in "Chinese Ethnic Medicines" that the seed kernel of Xanthomonas radix is ​​a traditional medicinal material of the Mongolian nationality. Incontinence, mental retardation in children, senile dementia, Parkinson's syndrome and other diseases [Institute for the Control of Pharmaceutical and Biological Products of the Ministry of Health, Chinese National Pharmaceutical Journal, People's ...