Application of compound of esters of piperic acid in preparing hypolipidemic or health products

A technology of piperine esters and compounds is applied in the application field of piperonic acid esters in the preparation of blood lipid-lowering drugs and health care products, and can solve problems such as literature reports that the application of piperonic acid esters is not found.

Inactive Publication Date: 2006-07-05
INNER MONGOLIA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no bibliographical report on the application of piperonate compounds in the preparation of blood lipid-lowering drugs and health products

Method used

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  • Application of compound of esters of piperic acid in preparing hypolipidemic or health products
  • Application of compound of esters of piperic acid in preparing hypolipidemic or health products
  • Application of compound of esters of piperic acid in preparing hypolipidemic or health products

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Experimental program
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Embodiment Construction

[0065] The beneficial effect of the application of the piperonate compounds of the present invention in blood lipid-lowering drugs and health products will be further illustrated by test examples below.

[0066] Blood lipid-lowering efficacy test and data of piperonate compounds.

[0067] 1 Experimental animals and materials

[0068] Experimental animals: second grade male Wistar rats, weighing 170±10g

[0069] (Provided by Animal Research Center of Inner Mongolia University).

[0070] Experimental reagents:

[0071] Piperic acid ester compounds: piperic acid, n-butyl piperate, isobutyl piperate, hexyl piperate, octyl piperate, and 6-nitrobutyl piperate are extracted and synthesized by our institute;

[0072] The total cholesterol kit was produced by Zhongsheng Beikong Biotechnology Co., Ltd.;

[0073] Production batch number: 180091, certificate number: Beijing T20010069

[0074] The triglyceride kit is produced by Zhongsheng Beikong Biotechnology Co., Ltd.;

[0075] Pr...

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Abstract

An application of peperate compounds in preparing the medicines or health-care food for preventing and treating cardiovascular disease, cerebrovascular disease, hyperlipemia, etc is disclosed.

Description

technical field [0001] The present invention relates to the application of piperine ester compounds, more specifically, the present invention relates to the application of piperine ester compounds in the preparation of blood lipid-lowering drugs and health care products Background technique [0002] Medical research shows that lipid metabolism is closely related to cardiovascular diseases, hyperlipidemia is one of the main causes of atherosclerosis, especially the increase of serum total cholesterol level is a risk indicator of atherosclerosis. Blood lipids are the general term for various lipids in serum. Blood lipids mainly include cholesterol, triglycerides, and phospholipids. In addition, there are a small amount of free fatty acids and very small amounts of other lipids, including fat-soluble vitamins and steroid hormones. Two-thirds of cholesterol exists in the form of cholesteryl esters, and the remaining one-third is free cholesterol. [0003] Cholesterol is not onl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/36A61P3/06
Inventor 博日吉汗格日勒图昭日格图那日苏吴勇白国义那木拉邓承远
Owner INNER MONGOLIA UNIVERSITY
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