1305 results about "Cerebro vascular disease" patented technology

This invention concerns the method of extracting salvianolic acid A from Chinese crude drug: danshen root, and the quality control methods and drug combinations, and the application of this drug. It can be used in the preparation of the prevention drugs for cardiovascular disease, liver damage, liver fibrosis, pulmonary fibrosis and other.

An implantable medical device is provided for the suppression or prevention of pain, movement disorders, epilepsy, cerebrovascular diseases, autoimmune diseases, sleep disorders, autonomic disorders, abnormal metabolic states, disorders of the muscular system, and neuropsychiatric disorders in a patient. The implantable medical device can be a neurostimulator configured to be implanted on or near a cranial nerve to treat headache or other neurological disorders. One aspect of the implantable medical device is that it includes an electronics enclosure, a substrate integral to the electronics enclosure, and a monolithic feed-through integral to the electronics enclosure and the substrate. In some embodiments, the implantable medical device can include a fixation apparatus for attaching the device to a patient.

The present invention discloses a slowly-released oral medicine preparation which is made up by using breviscapine as main raw material and has the functions of promoting blood circulation and removing blood stasis, removing obstruction in the channels to relieve pain for curing angiocardiopathy and cerebrovascular disease with obvious therapeutic effect and its preparation method. Said slowly-released tablet (by one tablet) contains 60-120 mg of breviscapine, 20-75 mg of diluent, 50-150 mg of filling agent and 10-50 mg of slow release material. Said invention also provides its preparation method and concrete steps.

An active component of red sage root, its slow-releasing agent, its medicinal application, and its preparing process are disclosed. In its effective region, the content of general solviolic acid is more than 80% and the content of salviolic acid A is more than 10%. Said slow-releasing agent is prepared through extracting in water or alcohol ic water, getting a supernatant, removing alcohol, dissolving in water, then washing to remove inpurities, eduting with alcohol, recovering alcohol eluent and drying. It can be used to prepare the medicine to prevent and cure cardiovascular and cerebrovascular diseases.

The invention relates to a brain vascular blood circulation dynamic analysis method and the apparatus thereof. According to the cerebral circulation vascular bed anatomical model, an equivalent network model which comprises 12 pipeline units simulating the brain circulation blood dynamics is built, and the relevant parameter calculation formulas are confirmed, by utilizing the formulas, the flow rate waveform and the value inside the cartid artery, the pressure waveform, the blood pressure of the body, the diameter of the blood vessel, the flow rate waveform and the valve of the vertebral artery and the front, the middle and the rear parts on two sides inside the skull, and the characteristic and the parameter of the cartid artery and each blood vessel section inside the skull can be determined, the apparatus designed by the invention can be performed, the detecting system comprises the vessel diameter detecting of the cartid artery outside the skull, the blood pressure detecting, theblood flow rate detecting of the cartid artery outside the skull, the pressure waveform detecting of the cartid artery outside the skull, and the blood flow rate detecting on the artery inside the skull; the control system comprises a control module and a power supply module; the calculation and analysis system comprises a host computer, a peripheral equipment, and an analog-digital converter, the invention can fully analyze the brain circulation dynamic characteristic, thereby having notable effect on the early stage and the ultra early stage diagnosis and therapy of the brain vascular illness.

Methods of treating metabolic diseases and disorders using a FGF21 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 1 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels, diabetic nephropathy, neuropathy, retinopathy, ischemic heart disease, peripheral vascular disease and cerebrovascular disease

A hemodynamic method and instrument for early diagnosis of cerebrovascular diseases features that the Doppler probe and ultrasonography B are used to detect the blood flowing speed, the ultrasonography B is used to detect the physical characteristics of blood vassel, the diameter and wall thickness of blood vessel are measured to obtain the flow of blood in the vessel, and a pressure probe is used to detect blood pressure.

The invention discloses a sea cucumber polypeptide functional food and a preparation method thereof which not only remarkably improves the content of polypeptide, but also has no chemical residues; the contents of salt and arsenic are low; the food is healthier and safer to eat; simultaneously the food is simply operated, easily controlled, is effective and saves energies. The key technical scheme includes: selecting a compound protease of Protamex and needing not to adjust the pH value of materials; carrying out processes of desalting and arsenic removing on an enzymolysis liquid; more than 80 percent of the molecular weight of the product is between 100 to 6000Dalt; wherein, the small polypeptide of 100 to 2100Dalt is more than 70 percent; the product components and the content weight percentages are as follows: 50 to 60 percent of polypeptide, 5 to 10 percent of free amino acids, 2.5 to 7.5 percent of mucoitin as well as containing the inherent nutrition components of a plurality of minerals and vitamins of the sea cucumber. The product has the effects of resisting knub, reducing blood pressure, preventing cardio-cerebrovascular diseases, resisting fatigue, delaying senescence, improving the immunity. The food can be used as a healthy food to eat and can also be used as a food and a medicine additive.

The invention relates to flour suitable for patients with diabetes mellitus. The flour is prepared by uniformly stirring powder made of traditional Chinese medicines, such as rhizoma polygonati, kudzu-vine root, Chinese yam, tuckahoe, semen coicis, mulberry fruit, frosted mulberry leaf, raw hawthorn and semen euryales and the mixed flour of different grain, such as soya bean, string bean, cow peaand wheat which are beneficial to the patients with diabetes mellitus in a certain proportion and can be used for producing various foods suitable for the patients with diabetes mellitus to have as aprincipal food. The special meal flour has the obvious effects of systemically adjusting glucose metabolism, lightening the pancreatic island load, improving carbohydrate tolerance, microcirculation and the function of the visceral organ, reducing blood fat and blood viscosity and eliminating radicals. The special meal flour is suitable for the patient withs diabetes mellitus, adiposity, hyperlipemia, high blood viscosity, adiposis hepatica, hypertension and heart cerebrovascular disease and middle-aged and old people to have as the principal food.

The invention relates to a baked fast food and a method for making the same, in particular to a trtary buckwheat potato crisp containing nutritional ingredients such as trtary buckwheat and the like and having dual effects of nutrition and health care and a method for making the same. The food is characterized by the addition of trtary buckwheat having the effects of preventing cardiovascular and cerebrovascular diseases and protecting health; and the food is made through a special fabrication process and has both nutritive value and health care function.

This invention discloses hydrates of pharmaceutical salts of hexahydro-1-(5-sulfonylisoquinoline)-1H-1,4-diaza, i.e., fasudil, especially semi-hydrates of nitrate, sulfate, hydrobromide and mesylate of fasudil, their preparation method, and their application in drugs for preventing and / or treating cardio-cerebrovascular diseases. The hydrates of pharmaceutical salts of fasudil have such advantages as high stability and high solubility, and can be manufactured into various preparations with other active components and / or pharmaceutically acceptable carriers. The method has such advantages as simple process, high drug purity, high yield, and stable product quality, and is suitable for industrial production.

The present invention discloses a medicine for curing angiocardiopathy and cerebrovascular disease. It is formed from ginseng stem and leaf saponin extracted from ginseng stem and leaf and peony total glycoside extracted from peony as raw material. Said medicine composition not only can promote blood circulation and remove stasis and relieve inflammation and stop pain, but also can supplement qi and promote the production of body fluid, and can raise immunity of human body, so that its therapeutic effect is greatly raised.

The invention publishes the preparation methods to produce ass hide and ginseng and stibene wine. This medicated wine has function of curing and health protection. The distilled spirit acts as groundsustance for ass hide and ginseng and stibene wine and then dip ginseng, prepared rehmannia root, dangshen, medlar, astragalus root, angelica, poria conos, licorice root, chuanxiong rhizome, white fat peony and bighead atractylodes rhizome, after this, add ass hide and sugar liquor to get the medicated wine. The thirteen good drug are mixed reasonably, the distilled spirit is used to dip and distill and sugar is used to season, so the drug can be absorbed by men. The invention has many function, such as helping buiding blood and invigoratin qi, strengthening the spleen and stomach, nourishing the heart and tranquilization, nourishing yin and moisturizing the lung, promoting blood circulation and improving acuity of vision and refreshment. It is good for not only weaken habitus but also blood vessel of brain and heart and gynecology illness.

The object of the present invention is to provide soluble β-amyloid precursor protein secretory stimulators, which are effective in treating neurodegenerative diseases as well as cerebrovascular disorder-induced neuronopathy. More specifically, the present invention provides a novel compound of the following Formula (I) or a salt or prodrug thereof: [wherein R1 and R2 each represent a hydrogen atom or a lower alkyl group, etc., Ar1 and the ring B each represent an optionally substituted aromatic group, the ring A represents an optionally substituted benzene ring, the ring C represents an optionally substituted 4- to 8-membered ring which may further be condensed with an optionally substituted ring, X represents CH or N, and Y represents CH or N].

Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, eg. a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, a inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding ageing, and prevention and / or treatment of skin ageing and skin protection against sunlight and / or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety, the neuroprotective function is imparted to the compound e.g. by a neuroprotective peptide, and a combined antiapoptotic and neuroprotective function by a propargyl group.

The invention belongs to the technical field of traditional Chinese medicine, particularly relates to a traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and a preparation method of the traditional Chinese medicine. The traditional Chinese medicine for treating the cardiovascular and cerebrovascular diseases is characterized being prepared from the following raw materials in parts by weight: 2 to 4 parts of radix panacis quinquefolii, 1 to 3 parts of dried human placenta, 5 to 7 parts of radix salviae miltiorrhizae, 5 to 7 parts of herba rhodiolae, 1 to 3 parts of schisandra chinensis fructus, 4 to 6 parts of head of angelica sinensis, 4 to 6 parts of Chuanxiong rhizoma, 3 to 5 parts of flesh of polygalae radix, 4 to 6 parts of hirudo, 4 to 6 parts of radix notoginseng, 4 to 6 parts of fried spina date seed, 7 to 9 parts of herba cistanche, 1 to 3 parts of saussurea involucrate, 3 to 5 parts of ganoderma lucidum spore, 2 to 4 parts of dendrobium officinale, 2 to 4 parts of grilled polygonum multiflorum, 4 to 6 parts of radix puerariae, 4 to 6 parts of rhizoma gastrodiae, and 9 to 11 parts of herba bidentis pilosae. Various herbs are matched to complement each other and to have functions for tonifying Qi, promoting blood circulation to remove blood stasis and activating main and collateral channels. The traditional Chinese medicine is widely used for treating the cardiovascular and cerebrovascular diseases.

Belonging to the field of pharmaceutical chemical engineering, the invention in particular relates to a variety of scutellarin aglycone crystal forms and a preparation method thereof. The invention also relates to application of the scutellarin aglycone crystal forms in preparation of drugs preventing and / or treating cardiovascular and cerebrovascular diseases, rheumatism arthritis, stroke sequelae and the like. The scutellarin aglycone crystal forms provided by the invention have good stability, and can overcome the poor oral absorption and low bioavailability problems of scutellarin.

The invention discloses a process for preparing hirudin by using blood- suction leeches, as well as its use, the preparing process consists of pulping leeches, formulating suspension and drying. The substance can be prepared into capsules, soft capsules, granules and tablets. The obtained medicament can be used for treating cardiovascular and cerebrovascular diseases including cerebral apoplexy, hypertension, hyperlipemia and coronary disease.

The invention relates to a de-polymerizing sea cucumber glycosamino-glycan compound, comprising 90-99. 89% of de-polymerizing sea cucumber glycosamino-glycan with weight average molecular weight being between 8000Da to 120000Da. The preparation method comprises following steps: (1) extracting sea cucumber polysaccharides from sea cucumber; (2) degrading extracted polysaccharides; (3) collecting de-polymerizing sea cucumber glycosamino-glycan with weight average molecular weight being between 8000Da to 120000Da. The compound can prevent and treat cerebrovascular disease and cardiovascular disease, especially blood coagulation disease and thrombus disease. The raw material is sea creature, so the source is abundant and cost is low.

The invention relates to the food scientific and technical field, and aims at providing a seafood flavoring prepared by using shrimp shell and a preparation method. The seafood flavoring is prepared by compounding the following components by weight percentage: 60%-70% of shrimp shell extract, 8%-15% of monosodium glutamate, 12%-20% of salt, 5%-10% of white sugar, 0.2%-0.5% of clove powder, 0.3%-0.6% of pepper, 0.2%-0.5% of fennel powder and 0.5%-1.0% of anti-oxidant. The components of the present invention have the advantages of reasonable compatibility, low production cost, good mouthfeel, delicious taste and abundant nutrients. The seafood flavoring contains rich active peptide, carnosine, amino acid, nucleotide, vitamin and trace elements, particularly to astaxanthin with the functionsof antioxidation, aging resistance, anti-tumor, cardio-cerebrovascular disease prevention and the like, the seafood flavoring is a good marine organism product.

This invention provides safflower uranidin prepd. from the Chinese herb medicine-safflower which isu sed for promoting blood circulation and removing blood disturbance, and the prepn. method and usage therefor. Said safflower uranidin is tested by high efficiency liquid phase chromatography with its content of 70-99.6%. It can be used for treating and preventing various kinds of diseases, such as cardiovascular disease, cerebrovascular disease and other blood circulation disturbance disease.

The invention discloses a detecting method for accurate risk early warning and accurate drug use of cardiovascular and cerebrovascular diseases and a specific primer. The invention provides a specific primer for detecting SNP site of drug resistance of the cardiovascular and cerebrovascular diseases, which comprises a primer group 1 and a primer group 2; the primer group 1 is composed of primer pair 1-primer pair 13; a primer group 2 is composed of single stranded extended primer 1- single stranded extended primer 13; the method can efficiently detect and complete the accurate early warning of the attack of the cardiovascular and cerebrovascular diseases and the accurate drug use after being attacked, namely, four kinds of cardiovascular and cerebrovascular disease early warning with huge health risk and accurate drug use of four clinical common drugs (aspirin, nitroglycerin, warfarin, and clopidogrel) for prevention and treatment of cardiovascular and cerebrovascular diseases.

The invention discloses bionic enzymatic hydrolysate for ground beeltle and application thereof, and belongs to the field of Chinese medicaments. The invention adopts the technical scheme that: a bionic enzymolysis method is adopted; the ground beeltle is taken; and after water is added in the ground beeltle so as to form homogenate, under proper conditions, the heat preserving enzymolysis is carried out firstly by pepsin, and then the heat preserving enzymolysis is carried out by pancreatin or trypsase. The obtained enzymatic hydrolysate is prepared into preparations according to different preparation requirements. The bionic enzymatic hydrolysate has the excellent effects in aspects of treating cardiovascular and cerebrovascular diseases, injuries from falls and the like.

The peony seed oil is rich in a great amount of unsaturated fattyacid, alpha-linolenic acid with maximal content in the peony seed oil is essential to the human body and has an important effect on improving the intelligence, protecting the vision and preventing cardiovascular and cerebrovascular diseases. But a majority of unsaturated fattyacid is easily oxidized, and the nutritional value of the peony seed oil is reduced. A preparation process of the water-soluble peony seed oil powder comprises the following steps of dissolving a wall material and an emulsifier into distilled water, stirring the wall material, the emulsifier and the distilled water until being adequately dissolved, slowly adding the peony seed oil to carry out the embedding at the temperature of 30 to 90 DEG C according to the ratio of the peony seed oil to the wall material of 1: 10 to 5: 10, adequately mixing the solution, homogenizing and emulsifying the mixture under the pressure condition of 100 to 1000 bar to obtain an emulsified solution, and carrying out spray drying or freezing drying on the emulsified solution, thus preparing the water-soluble peony seed oil powder product. The water-soluble powder product has the advantages that the oxidation of the peony seed oil can be prevented, convenience in carrying can be realized and the like, and after the water-soluble peony seed oil powder is added into the drinking water, a stable emulsion system with good dispersion can be formed. The water-soluble powder can be used as a mate for the drink such as coffee, contains no trans-fatty acids and is safe and nutritional.

The invention relates to a traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases, mainly containing one or more of Salvia miltiorrhiza, folium ginkgo, panax notoginseng, kudzuvine root Pueraria lobata, rhizoma ligustici wallichii, hawthorn and lotus leaf. The preparation method comprises the steps of selecting one or more of the Salvia miltiorrhiza, the folium ginkgo, the panax notoginseng, the kudzuvine root Pueraria lobata, the rhizoma ligustici wallichii and the hawthorn and lotus leaf, decocting, extracting active ingredients and concentrating the extracting solution to a certain concentration to obtain the Chinese traditional medicine preparation. In addition, the concentrated solution can be further made into capsules, tablets, granules, oral liquid, pills, pulvis, injection and sustained and controlled release preparations. Toxicologic and pharmacologic agent experiments show that the invention has no toxic side effect, is safe to use, has the functions of promoting blood circulation, remove blood stasis, reducing fat, freeing channels and eliminating phlegm and is suitable for phlegm stasis internal-block type cardiovascular and cerebrovascular diseases.

The invention discloses a novel conjugate composed of a hydrophilic polymer and resveratrol, a pharmaceutical composition including the conjugate, their preparation methods and applications in the preparation of drugs for treating tumor, diabetes and cardio cerebrovascular disease, wherein the hydrophilic polymer is selected from the group consisting of polyethylene glycol, polyglutamic acid, polyaspartic acid, polypropylene glycol, polyvinyl alcohol, polypropylene morpholine, polyethylene glycol-amino acid oligopeptide and their copolymer. Through modification of the hydrophilic polymer, a bound drug can be protected, stability and water solubility of the conjugate are raised, and active period of the conjugate in organisms is prolonged.

The present invention relates to, among other things, methods for treating trigeminal cephalgias such as migraine and migraine like headaches and other cerebrovascular conditions associated with pain and or inflammation. When non-steroidal anti inflammatory drugs (NSAIDs), such as ketoprofen, are applied locally using specific topical formulations immediate relief of pain is obtained. Intense pain is typically reduced to mild pain or no pain within 30 minutes of application of the topical formulation. The NSAID may be given in combination with other pharmacological agents, such as vasoconstrictors, opioids, decongestants and / or non-opioid migraine drugs, such as triptans and ergots and agents that affect serotonin receptors as agonists, antagonists or partial agonists.