Bionic enzymatic hydrolysate for ground beeltle and application thereof

Abstract

The invention discloses bionic enzymatic hydrolysate for ground beeltle and application thereof, and belongs to the field of Chinese medicaments. The invention adopts the technical scheme that: a bionic enzymolysis method is adopted; the ground beeltle is taken; and after water is added in the ground beeltle so as to form homogenate, under proper conditions, the heat preserving enzymolysis is carried out firstly by pepsin, and then the heat preserving enzymolysis is carried out by pancreatin or trypsase. The obtained enzymatic hydrolysate is prepared into preparations according to different preparation requirements. The bionic enzymatic hydrolysate has the excellent effects in aspects of treating cardiovascular and cerebrovascular diseases, injuries from falls and the like.

Description

technical field [0001] The invention relates to a biomimetic enzymatic hydrolyzate of the traditional Chinese medicine ground beetle and its application in cardiovascular and cerebrovascular diseases. It belongs to the field of traditional Chinese medicine. Background technique [0002] Eupolyphaga sinesis Walker (Eupolyphaga sinesis Walker) or Steleophage plancyi (Boleny) is the dried female body of Eupolyphaga sinesis Walker or Steleophageplancyi (Boleny). Salty, slightly toxic. It has the functions of dispersing blood stasis, reconnecting bones and tendons, reducing swelling and relieving pain, and promoting menstrual flow. [0003] As a traditional Chinese medicine, ground beetle is widely used clinically. The way of medicine is usually to take the raw medicinal materials directly after being crushed, or to take after water extraction or alcohol extraction or water extraction and alcohol precipitation. The extraction method adopted is relatively traditional. Current r...

AI Technical Summary

Problems solved by technology

Current research shows that small molecule oligopeptides and amino acids are easily absorbed by the small intestine, while large molecule proteins are difficult to absorb in the small intestine

The traditional raw powder is taken directly. Only a small amount of macromolecular protein in the raw drug powder is decomposed in the gastrointestinal tract in the body and becomes small molecular oligopeptides to be absorbed. If the hydrolysis is not completed, the active ingredients will be absorbed and utilized less, resulting in the waste of a large amount of medicinal materials and greatly reducing the curative effect

The extraction process of water extraction and alcohol precipitation makes most of the protein insoluble in water and alcohol be filtered out, resulting in a lot of waste of medicinal materials and greatly reducing the curative effect

[0004] With the deepening of people's understanding of animal medicine, some people have made preparations from a single protein extracted from ground beetles, but when made into oral preparations, they are easily digested by gastric enzymes and pancreatin after passing through the gastrointestinal tract, and their activity is lost. ; If it is made into an injection, there is a certain potential safety hazard due to the fact that the macromolecular proteins are likely to cause immunogenicity

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