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Oral solid preparation containing desmodium styracifolium general flavone and application thereof

A technology of Desmodium mongolica and solid preparations, applied in the direction of medical preparations containing active ingredients, medical preparations with non-active ingredients, pill delivery, etc.

Active Publication Date: 2014-07-02
HUMANWELL HEALTHCARE GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the related preparations of total flavonoids of Desmodium stylifolia still needs to be strengthened

Method used

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  • Oral solid preparation containing desmodium styracifolium general flavone and application thereof
  • Oral solid preparation containing desmodium styracifolium general flavone and application thereof
  • Oral solid preparation containing desmodium styracifolium general flavone and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Embodiment 1, the preparation of total flavonoids of Desmodium radix

[0140] (1) Extraction method: According to the solubility of flavonoids, free flavonoids and flavonoid glycosides can generally be extracted with organic solvents, and industrial production usually uses higher concentration of ethanol for extraction. This study is based on the general industrial extraction method of flavonoids On the basis of that, 60%-95% ethanol is selected as the extraction solvent, and the number of extraction times is more economical and practical to extract twice according to the common production method.

[0141]Ethanol reflux extraction process experiment: using L9 (3 4 ) Orthogonal test method, taking the total flavonoids of Desmodium sativa as the investigation index, determine the process parameters of factors such as ethanol concentration, ethanol consumption (multiple of the amount of Desmodium sativa) and extraction time, and adopt the ultraviolet-visible spectrophotome...

Embodiment 2

[0185] Embodiment 2, the preparation of total flavonoids of Desmodium radix

[0186] Take 50 grams of Herba Desmanthus herb, add 12 times the amount of 80% ethanol for the first time, heat and reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat and reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, so that the volume of the medicinal solution is 5 times the amount of medicinal materials, stand and filter to obtain the filtrate (which is the loading medicinal solution), and set aside. Soak 100 kg of pharmaceutical grade AB-8 macroporous resin with an appropriate amount of ethanol, wet-pack the column, and treat it for later use. Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the column bed volume per hour. 60% ethanol in the bed volume was eluted at a flow rate of 2 times the column bed...

Embodiment 3

[0187] Embodiment 3, the preparation of total flavonoids of Desmodium radix

[0188] Take 200 grams of Desmodium sativa, add 12 times the amount of 80% ethanol for the first time, heat and reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat and reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, so that the volume of the medicinal solution is 5 times the amount of medicinal materials, stand and filter to obtain the filtrate (which is the loading medicinal solution), and set aside. Soak 400 grams of pharmaceutical grade AB-8 macroporous resin with an appropriate amount of ethanol, wet-pack the column, and prepare it for later use.

[0189]Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the column bed volume per hour. 60% ethanol in the bed volume was eluted at a flow rate of 2 times the c...

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Abstract

The invention provides an oral solid preparation containing desmodium styracifolium general flavone and application thereof, wherein the oral solid preparation containing the desmodium styracifolium general flavone comprises desmodium styracifolium general flavone which is an alcohol extract of desmodium styracifolium, and medicinal auxiliary materials. The oral solid preparation containing the desmodium styracifolium general flavone disclosed by the invention has the characteristics of being explicit in effective material basis, controllable in quality standard, good in drug dissolution degree, high in bioavailability, good in quality stability, significant in pharmacology and drug efficacy, less in dosage, safe and convenient to take, and completely applicable to industrial massive production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to an oral solid dispersion containing total flavonoids of Desmodium stylifolia and an application thereof. More specifically, the present invention relates to a solid dispersion containing total flavonoids of Desmodium stylifolia as an active ingredient, preparation of a solid dispersion preparation of total flavonoids of Desmodium stylifolia and a preparation method thereof, as well as a solid dispersion and a solid dispersion preparation of total flavonoids of Desmodium stylifolia Use in the preparation of medicines for treating urolithiasis. Background technique [0002] Desmodium styracifolium (Osb.) Merr. is a leguminous plant. The dry aerial part of Desmodium styracifolium (Osb.) Merr. is a traditional Chinese medicine recorded in the 2010 edition of "Chinese Pharmacopoeia". . Simultaneously recorded prescription Shilintong Tablets, the main i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/16A61K9/20A61K9/48A61K47/34A61K47/32A61K47/20A61P13/04
CPCA61K9/146A61K9/148A61K9/1623A61K9/2054A61K9/4808A61K2236/00A61K36/48A61P13/04A61K9/2095A61K9/4833
Inventor 王学海李莉娥许勇李杰涂荣华陈刚曹儒宾冯芸杨仲文范昭泽余艳平肖强黄璐杨成兵黄天赐田华杨菁
Owner HUMANWELL HEALTHCARE GRP
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