Oral solid preparation containing total flavonoids of Desmodium glabra and its application

A technology of Desmodium radix and total flavonoids, applied in the field of pharmaceutical preparations

Active Publication Date: 2017-09-29
HUMANWELL HEALTHCARE GRP +1
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on the related preparations of total flavonoids of Desmodium stylifolia still needs to be strengthened

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oral solid preparation containing total flavonoids of Desmodium glabra and its application
  • Oral solid preparation containing total flavonoids of Desmodium glabra and its application
  • Oral solid preparation containing total flavonoids of Desmodium glabra and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0139] Embodiment 1, the preparation of total flavonoids of Desmodium radix

[0140] (1) Extraction method: According to the solubility of flavonoids, free flavonoids and flavonoid glycosides can generally be extracted with organic solvents, and industrial production usually uses higher concentration of ethanol for extraction. This study is based on the general industrial extraction method of flavonoids On the basis of that, 60%-95% ethanol is selected as the extraction solvent, and the number of extraction times is more economical and practical to extract twice according to the common production method.

[0141] Ethanol reflux extraction process experiment: using L9 (3 4 ) Orthogonal test method, taking the total flavonoids of Desmodium sativa as the investigation index, determine the process parameters of factors such as ethanol concentration, ethanol consumption (multiple of the amount of Desmodium sativa) and extraction time, and adopt the ultraviolet-visible spectrophotom...

Embodiment 2

[0185] Embodiment 2, the preparation of total flavonoids of Desmodium radix

[0186] Take 50 grams of Herba Desmanthus herb, add 12 times the amount of 80% ethanol for the first time, heat and reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat and reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, so that the volume of the medicinal solution is 5 times the amount of medicinal materials, stand and filter to obtain the filtrate (which is the loading medicinal solution), and set aside. Soak 100 kg of pharmaceutical grade AB-8 macroporous resin with an appropriate amount of ethanol, wet-pack the column, and treat it for later use. Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the column bed volume per hour. 60% ethanol in the bed volume was eluted at a flow rate of 2 times the column bed...

Embodiment 3

[0187] Embodiment 3, the preparation of total flavonoids of Desmodium radix

[0188] Take 200 grams of Desmodium sativa, add 12 times the amount of 80% ethanol for the first time, heat and reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat and reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, so that the volume of the medicinal solution is 5 times the amount of medicinal materials, stand and filter to obtain the filtrate (which is the loading medicinal solution), and set aside. Soak 400 grams of pharmaceutical grade AB-8 macroporous resin with an appropriate amount of ethanol, wet-pack the column, and prepare it for later use.

[0189] Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the column bed volume per hour. 60% ethanol in the bed volume was eluted at a flow rate of 2 times the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an oral solid preparation containing total flavonoids of Desmodium stylifolia and application thereof. Wherein, the oral solid preparation containing total flavonoids of Desmodium styliformis comprises: total flavonoids of Desmodium stylifolia, which is an alcohol extract of Desmodium stylifolia; and pharmaceutical excipients. The oral solid preparation of total flavonoids of Desmodium sativa of the present invention has clear effective substance base, controllable quality standard, good drug dissolution rate, high bioavailability, good quality stability, remarkable pharmacological effect, less dosage, safe and convenient to take , Fully suitable for the characteristics of industrialized mass production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and specifically relates to an oral solid dispersion containing total flavonoids of Desmodium stylifolia and an application thereof. More specifically, the present invention relates to a solid dispersion containing total flavonoids of Desmodium stylifolia as an active ingredient, preparation of a solid dispersion preparation of total flavonoids of Desmodium stylifolia and a preparation method thereof, as well as a solid dispersion and a solid dispersion preparation of total flavonoids of Desmodium stylifolia Use in the preparation of medicines for treating urolithiasis. Background technique [0002] Desmodium styracifolium (Osb.) Merr. is a leguminous plant. The dry aerial part of Desmodium styracifolium (Osb.) Merr. is a traditional Chinese medicine recorded in the 2010 edition of "Chinese Pharmacopoeia". . Simultaneously recorded prescription Shilintong Tablets, the main i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61K9/16A61K9/20A61K9/48A61K47/10A61K47/32A61K47/20A61P13/04
CPCA61K9/146A61K9/148A61K9/1623A61K9/2054A61K9/4808A61K2236/00A61K36/48A61P13/04A61K9/2095A61K9/4833
Inventor 王学海李莉娥许勇李杰涂荣华陈刚曹儒宾冯芸杨仲文范昭泽余艳平肖强黄璐杨成兵黄天赐田华杨菁
Owner HUMANWELL HEALTHCARE GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap