Medicine composition and the preparing method and the content testing method

A composition and drug technology, applied in the field of medicine, can solve the problems of limiting the comprehensive curative effect of blue palm fruit, inconvenient clinical medication, high production cost, etc., and achieve the effects of reducing clinical dosage, saving raw materials, and easy operation

Active Publication Date: 2010-05-12
CHENGDU DIAO JIUHONG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the blue palm fruit preparations at home and abroad all use its fat-soluble components as the active ingredients for the treatment of benign prostatic hyperplasia, while ignoring its water-soluble components, so that the polysaccharides in the blue palm fruit that play an immunostimulatory role cannot play a role, to a certain extent Limiting the comprehensive curative effect of blue palm fruit
At the same time, the conventional preparation method has brought inconvenience to clinical medication due to the large amount of auxiliary materials and high production cost.

Method used

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  • Medicine composition and the preparing method and the content testing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] [Example 1] Preparation and content determination of the pharmaceutical composition of the present invention

[0028] Preparation: Take 10kg of blue palm fruit and crush, add 4 times the amount of 80% ethanol, reflux extraction twice, each time for 2 hours, filter, combine the filtrate, recover the ethanol under reduced pressure to the end, collect the extract; add to the extract Add water 3 times the volume of the extract, stir evenly, refrigerate at 4°C for 12 hours, filter, separate the oil layer and water layer, heat and melt the oil layer; weigh a certain amount of β-cyclodextrin, disperse evenly in the water layer, and add to the oil layer , the volume ratio of the oil layer, β-cyclodextrin, and water layer is 1:0.5:1, grind to a paste, collect the paste, dry, pulverize, and sieve to obtain a pharmaceutical composition containing blue palm fruit extract , the pharmaceutical composition of the present invention.

[0029] Content determination: take 150 mg of the p...

Embodiment 2

[0030] [Example 2] preparation and content determination of the pharmaceutical composition of the present invention

[0031] Preparation: Take 10 kg of blue palm fruit and grind it, add 6 times the amount of 95% ethanol, reflux extraction twice, each time for 3 hours, filter, combine the filtrate, recover the ethanol under reduced pressure to the end, collect the extract; add to the extract Add water 4 times the volume of the extract, stir evenly, refrigerate at 4°C for 18 hours, filter, separate the oil layer and water layer, heat and melt the oil layer; weigh a certain amount of β-cyclodextrin, disperse evenly in the water layer, add to the oil layer , the volume ratio of the oil layer, β-cyclodextrin, and water layer is 1:2:4, grind to a paste, collect the paste, dry, pulverize, and sieve to obtain a pharmaceutical composition containing blue palm fruit extract , the pharmaceutical composition of the present invention.

[0032]Content determination: take 150 mg of the phar...

Embodiment 3

[0033] [Example 3] preparation and content determination of the pharmaceutical composition of the present invention

[0034] Preparation: Take 10kg of blue palm fruit and grind it, add 8 times the amount of 90% ethanol, reflux extraction 3 times, each time for 3 hours, filter, combine the filtrate, recover the ethanol under reduced pressure to the end, collect the extract; add to the extract Mix 5 times the volume of the extract with water, stir evenly, refrigerate at 4°C for 24 hours, filter, separate the oil layer and water layer, heat and melt the oil layer; weigh a certain amount of β-cyclodextrin, disperse evenly in the water layer, and add to the oil layer , the volume ratio of the oil layer, β-cyclodextrin, and water layer is 1:4:5, grind to a paste, collect the paste, dry, pulverize, and sieve to obtain a pharmaceutical composition containing blue palm fruit extract , the pharmaceutical composition of the present invention.

[0035] Content determination: take 150 mg ...

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Abstract

The present invention relates to one kind of medicine composition and its preparation process and content measuring method. The medicine composition consists of liposoluble sabal fruit extract 10-30 wt%, water soluble sabal fruit extract 10-30 wt%, and beta-cyclodextrin 40-75 wt%, and contains lauric acid more than 1.84 wt%. It contains whole effective components of sabal fruit, and has less supplementary material, convenient clinical use and low cost.

Description

technical field [0001] The invention relates to a pharmaceutical composition, its preparation method and content determination method, in particular to a pharmaceutical composition containing blue palm fruit extract, its preparation method and content determination method, belonging to the technical field of medicine. Background technique [0002] Blue palm fruit is the mature fruit of saw palmetto Serenoa repens (Hook, F.). Saw palmetto grows on the South Atlantic coast of the United States and Florida, as well as southern Europe and northern Africa. The local people traditionally use it to treat cystitis and chronic bronchitis , asthma, diabetes, dysentery, indigestion and other diseases, and the fruit of saw palmetto, the blue palm fruit, is considered to be an aphrodisiac, and is now widely used in the treatment of benign prostatic hyperplasia. [0003] Blue palm fruit contains a large amount of fat, polysaccharides and other components, and the fat-soluble components ar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/889A61P13/08A61P13/10G01N30/02G01N33/15A61K131/00
Inventor 刘瑜何民王晓凤白红艳刘忠荣及元乔李伯刚
Owner CHENGDU DIAO JIUHONG PHARMA FAB
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