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Preparation method and application of active parts of Xingbei Zhike Granules

A technology of apricot shell for relieving cough and active parts, applied in the field of pharmacy, which can solve the problems of low active ingredient content, inconvenient clinical administration, large dosage of granules, etc., and achieve the effects of small clinical dosage, low cost, and low ointment yield

Active Publication Date: 2021-04-27
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the technical problems of Xingbei Zhike Granules in the prior art, such as single dosage form, large dose of granules, easy moisture absorption, low active ingredient content, and inconvenient clinical administration, the present invention aims to provide a low-cost, high-transfer rate, Active parts of Xingbei Zhike Granules suitable for industrial production

Method used

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  • Preparation method and application of active parts of Xingbei Zhike Granules
  • Preparation method and application of active parts of Xingbei Zhike Granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 The preparation method of the active part of Xingbei Zhike Granules

[0035] Prescription: honey-roasted ephedra 100g, bitter almond 333g, bellflower 200g, Peucedanum 200g, fritillary fritillary 200g, hundred-headed 200g, northern ginseng 333g, wood butterfly 100g, licorice 100g.

[0036] Step 1, reflux extraction: weigh Xingbeizhike granules medicinal materials according to the prescription amount, take the 4 raw materials of ephedra, Qianhu, Fritillaria and Baibu, add 6 times the amount of 70% ethanol for reflux extraction twice, each time 2 hour, filter, add 4 times the amount of 70% ethanol to the dregs, reflux for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative density of 1.07 (60°C), and set aside. Add 10 times the amount of water to the four flavors of platycodon root, northern Adenophora, wood butterfly and licorice, add bitter almonds after boiling, boil for 1.5 hours, filter, add 8 times the...

Embodiment 2

[0039] Example 2 The preparation method of the active part of Xingbei Zhike Granules

[0040]Prescription: honey-roasted ephedra 100g, bitter almond 333g, bellflower 200g, Peucedanum 200g, fritillary fritillary 200g, hundred-headed 200g, northern ginseng 333g, wood butterfly 100g, licorice 100g.

[0041] Step 1, reflux extraction: weigh Xingbeizhike granules medicinal materials according to the prescription amount, take the four raw materials of ephedra, Qianhu, Fritillaria and Baibu, add 8 times the amount of 70% ethanol for reflux extraction twice, each time 2 hours, filter, add 4 times the amount of 70% ethanol to the dregs, reflux for 2 hours, filter, combine the filtrates, concentrate under reduced pressure to a clear paste with a relative density of 1.06 (60°C), and set aside. Add 10 times the amount of water to the raw materials of platycodon grandiflorum, northern ginseng, wood butterfly and licorice, add bitter almonds after boiling, boil for 2 hours, filter, add 10 t...

experiment example 1

[0048] Experimental Example 1 Cough Relief Test of Each Extraction Part

[0049] Ammonia-induced coughing method in mice: SPF-grade ICR healthy mice, weighing 18-22 g, were randomly divided into 8 groups, 10 in each group, half male and half male. That is, the model group (0.5% CMC-Na), the positive control group (pentoxyverine tablets), the Xingbei Zhike Granules group (commercially available Xingbei Zhike Granules), the water-washed site group (the water eluate in Step 2 of Example 2) dry paste obtained after treatment), 30% ethanol elution site group (dry cream obtained after 30% ethanol eluent treatment in embodiment 2 step 2), 50% ethanol elution site group (50% ethanol eluent in comparative example 1 ethanol elution site dry cream), embodiment 1 active site group, embodiment 2 active site group. Among them, the doses of the Xingbei Zhike Granules group, the water-washed part group, the 30% ethanol eluted part group, the 50% ethanol eluted part group, the active part gro...

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Abstract

The invention discloses a preparation method of the active part of Xingbei Zhike Granules, which comprises the following steps: weighing the raw materials according to the weight ratio of the compound: taking the raw materials of ephedra ephedra, peucedanum, fritillary fritillary and Baibu four flavors, adding 4 ‑8 times the amount of 50‑80% ethanol was refluxed for 1‑3 hours, filtered, and the filtrate was concentrated under reduced pressure to obtain a clear paste; platycodon grandiflorum, Adenophora, wood butterfly, licorice and bitter almond, boiled for 1‑3 hours, filtered, The filtrate is concentrated under reduced pressure to obtain a clear paste; the above two clear pastes are combined, mixed uniformly, purified by a non-polar macroporous resin chromatography column, and used as water, 20-35% ethanol solution, and 60-95% ethanol solution. The eluent is used to elute the resin column, and 60‑95% ethanol eluate is collected. The method provided by the invention can solve the technical problems of Xingbei Zhike Granules in the prior art, such as single dosage form, large dosage, low active ingredient content, inconvenient clinical use, etc., can reduce production costs, and improve the transfer rate of active ingredients, so it is more effective Suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to an extraction method of active parts of Xingbei Zhike Granules and its application in the preparation of medicines for treating cough, and belongs to the technical field of extraction methods of active parts of traditional Chinese medicine compound. Background technique [0002] Cough refers to a disease characterized by exogenous pathogenic factors or internal injuries, leading to loss of ventilation and depletion of the lungs, upward reversal of lung qi, impingement on the airway, coughing sound or accompanied by expectoration. Exogenous cough is caused by exogenous six evils; internal injury cough is caused by internal injury factors such as diet and emotions, which cause dysfunction of viscera and internal pathogens. Exogenous cough and internal injury cough are both caused by pathogenic factors that cause lung qi to be unclear and lose Xuansu, and cough due to forced qi u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/904A61P11/14A61P11/10
CPCA61K36/17A61K36/185A61K36/23A61K36/346A61K36/484A61K36/736A61K36/8966A61K36/904A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61P11/10A61P11/14A61K2300/00
Inventor 肖伟胡玉梅杨彪周宇黄文哲曹泽彧曹亮柴尧王振中
Owner JIANGSU KANION PHARMA CO LTD
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