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Amlodipine besylate tablet and preparation method thereof

A kind of technology of amlodipine besylate tablets and magnesium stearate, applied in the field of medicine, can solve the problem of affecting product yield, active ingredient content and dissolution rate, being unstable to light, humidity and heat, and affecting product dissolution rate. and other problems, to achieve the effect of improving content uniformity and dissolution, ensuring dissolution and high dissolution

Inactive Publication Date: 2019-07-02
HUNAN QIANJIN XIELI PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the preparation process of amlodipine besylate tablets, there is a phenomenon that the raw materials are easily aggregated or adhered to the inner wall of the container due to electrostatic effects, thereby affecting the product yield and the content and dissolution rate of active ingredients.
Among the required raw materials, the main component amlodipine besylate is unstable to light, humidity and heat, and the auxiliary material anhydrous calcium hydrogen phosphate is heavy, while microcrystalline cellulose is light in texture, which makes it difficult to mix evenly. Thereby further affecting the dissolution rate of the product, resulting in a reduction in drug efficacy

Method used

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  • Amlodipine besylate tablet and preparation method thereof
  • Amlodipine besylate tablet and preparation method thereof
  • Amlodipine besylate tablet and preparation method thereof

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Embodiment 1

[0048] A kind of amlodipine besylate tablet, this amlodipine besylate tablet comprises the following components by weight percentage:

[0049] Amlodipine Besylate 2.5%,

[0050] Micropowder silica gel 0.5%,

[0051] Microcrystalline Cellulose 62%,

[0052] Dicalcium Phosphate Anhydrous 32%,

[0053] Magnesium stearate 2% added,

[0054] Sodium carboxymethyl starch 0.5%,

[0055] Plus magnesium stearate 0.5%.

[0056] The preparation method of the amlodipine besylate sheet of the present embodiment may further comprise the steps:

[0057] (1) Take the raw and auxiliary materials in the above formula, first mix amlodipine besylate and micropowder silica gel evenly to obtain the mixed material A, and then pass through a 120-mesh sieve; then pass anhydrous calcium hydrogen phosphate through a 200-mesh sieve, microcrystalline Cellulose is passed through a 100-mesh sieve, sodium carboxymethyl starch and magnesium stearate are passed through a 80-mesh sieve;

[0058] (2) Disso...

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Abstract

The invention relates to an amlodipine besylate tablet, and mainly solves the technical problems of low yield and poor dissolution rate of existing products. The key point of the technical solution isas follows: the amlodipine besylate tablet is characterized in that the amlodipine besylate tablet comprises amlodipine besylate, micro-powder silica gel, microcrystalline cellulose, anhydrous calcium hydrogen phosphate, magnesium stearate and sodium carboxymethyl starch. The amlodipine besylate tablet is mainly applied to the technical field of medicines.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an amlodipine besylate tablet and a preparation method thereof. Background technique [0002] Amlodipine besylate is a dihydropyridine calcium antagonist, which mainly inhibits the calcium storage capacity of the myocardial and vascular smooth muscle cell membranes and the ability to combine with calcium ions, and achieves the antihypertensive effect by dilating vascular arterioles and reducing peripheral resistance. [0003] In the preparation process of amlodipine besylate tablets, there is a phenomenon that the raw materials are easily aggregated or adhered to the inner wall of the container due to electrostatic effects, thereby affecting the product yield and the content and dissolution rate of active ingredients. Among the required raw materials, the main component amlodipine besylate is unstable to light, humidity and heat, and the auxiliary material anhydrous ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61K47/04A61K47/02A61K47/38A61K47/12A61P9/12
CPCA61K9/2009A61K9/2013A61K9/2054A61K9/2095A61K31/4422
Inventor 叶胜利
Owner HUNAN QIANJIN XIELI PHARMA CO LTD
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