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76results about How to "Good slow release function" patented technology

Controlled release type potassium ferrate composite as well as preparation method and application thereof

The invention discloses a controlled release type potassium ferrate composite as well as a preparation method and application thereof. The preparation method is as follows: by taking a high polymer which is biodegradable and environment-friendly as a framework material, dissolving the high polymer in a low-boiling point organic solvent, adding a pore-foaming agent, a dispersing agent and high-purity potassium ferrate, adding the mixture into a medium for emulsifying and curing, and filtering and drying the cured product to obtain the controlled release type potassium ferrate composite. The composite is in a water environment, so that a net-shaped duct structure is formed in an inert framework material by virtue of the hydrophilcity of the pore-foaming agent, and therefore, the potassium ferrate is effectively aided to release from the composite, and a problem that dissolution of active ingredients is affected due to texture compaction of the framework material is avoided; the composite is different from the conventional disposable oxidant, controllable in release speed in water, uniform in velocity, long in holding time, good in storage stability, and has wide application prospect on in-situ repairing polluted underground water.
Owner:SOUTH CHINA NORMAL UNIVERSITY

Dyeing and finishing process for polyester blended fiber fabric

The invention discloses a dyeing and finishing process for a polyester blended fiber fabric. The process comprises the following steps of 1, pretreatment, wherein the polyester blended fiber fabric is sequentially subjected to scouring, bleaching and enzyme washing; 2, mercerizing and sizing, wherein the fabric is subjected to padding of alkali liquor under the room temperature for pre-sizing; 3, dyeing, wherein the fabric is soaked into dye liquor formed by disperse dyes, dyeing is performed under the temperature of 30-40 DEG C, temperature is increased to 90-110 DEG C at the heating rate being 0.8-1 DEG C/min, washing is performed through warm water, infrared ray pre-heating is performed, and then hot-blast air drying is performed; padding is performed again under the room temperature to reduce the suspended solid dye liquor formed by dyes, a reduction solution is subjected to padding, steam reduction and oxidation are performed, washing is performed through warm water, soaping is performed, and then washing and drying are performed; 4, after-treatment, wherein soft and flame-proof treatment is performed in sequence. According to the dyeing and finishing process for the polyester blended fiber fabric, the touch feeling, elasticity and other properties of the fabric are improved remarkably, dyeing is uniform, the color fastness is high, and the color is full.
Owner:ANHUI YAYUAN PRINTING & DYEING CO LTD

Polyester-cotton microcapsule disperse reactive dye one-bath dyeing technology

The invention discloses a polyester-cotton microcapsule disperse reactive dye one-bath dyeing technology. The technology comprises the steps of: S1, polyester dyeing: dipping a to-be-dyed polyester-cotton fabric in a dye solution containing microcapsule disperse dye, conducting heat preservation at 65-75DEG C, then performing heat preservation at 110-130DEG C, and carrying out cooling to 30-40DEG C, using chitosan to serve as the carrier of the disperse dye, and then conducting crosslinking curing; S2. cotton dyeing: adding a quaternary ammonium salt cationic etherifying agent, carrying out stirring reaction, then adding a reactive dye, performing heat preservation at 55-65DEG C, adding an organic solvent, conducting heat preservation at 70-90DEG C, then adding organic amine and sodium carbonate, and performing heat preservation at 60-100DEG C; and S3, aftertreatment: performing cooling to room temperature, and then carrying out primary washing, soaping and after-washing. The polyester-cotton microcapsule disperse reactive dye one-bath dyeing technology provided by the invention has the advantages of simple process, little pollution, wide dye applicability, uniform coloring, high color fixation rate and good level-dyeing properties.
Owner:ANHUI YAYUAN PRINTING & DYEING CO LTD

Preparation method of ivermectin sustained-release microspheres

The invention relates to ivermectin sustained-release microspheres used as an animal medicine for animal injection, and a preparation method thereof. The invention belongs to an interdisciplinary field of biomedical polymer materials and controlled release preparations. The invention discloses ivermectin sustained-release microspheres, which are characterized in that: the ivermectin sustained-release microspheres have particle sizes of 0.1 to 10mum, a medicine loading capacity of 20% to 35%, and an entrapment rate of above 80%. The preparation method of the ivermectin sustained-release microspheres comprises steps that: a carrier material and the medicine ivermectin with a mass ratio of 1:1-10 are dissolved in an organic solvent; the solution is processed through supersonic wave or mechanical stirring, such that the solution is emulsified into an oil phase, wherein a volume ratio of oil phase to water phase is 1:5-10; under a temperature of -10 DEG C to 30 DEG C, the oil phase is injected into a water phase disperse medium solution step-by-step; constant-temperature magnetic stirring is carried out with a rotation speed of 400 to 10000rpm, the mixture is sufficiently emulsified, such that an S/O/W type emulsion is obtained; the emulsion is stirred under room temperature for 3 to 4 hours, such that the organic solvent is sufficiently volatilized; the obtained product is centrifuged, washed, collected, and is vacuum-dried with a pressure of 0.01 to 0.04MPa under room temperature for 10 to 12 hours or is lyophilized under a temperature of -0 DEG C to -20 DEG C. With the processes, ivermectin sustained-release microspheres with particle sizes of 0.1 to 10mum are obtained.
Owner:INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI

Composite drug carried microsphere, minocycline hydrochloride nano controlled-release composite drug carried microsphere system and preparation method thereof

The invention relates to a composite drug carried microsphere, a minocycline hydrochloride nano controlled-release composite drug carried microsphere system and a preparation method thereof. A drug carried system with a nuclear shell structure is formed by embedding minocycline hydrochloride inside a poly D,L-lactide-co-glycolic acid polymer microsphere and covering a cationic polymeric liposome prepared from O-QACMC modified by polyethylene glycol, O-QACMC and cholesterol outside the poly D, L-lactide-co-glycolic acid polymer microsphere; and the composite drug carried microsphere system covered and carried with the minocycline hydrochloride has the grain diameter ranging from 340 nm to 400 nm and positive surface Zeta electric potential. The composite drug carried microsphere system can be remained in a water solution for at least 2 months, has high entrapment rate reaching larger than 90 percent on drugs and strong drug carrying capacity reaching 9 percent. The minocycline hydrochloride nano controlled-release composite drug carried microsphere system has the characteristics of uniform and controllable grain diameter, good preparation stability, simple preparation process, high drug carrying rate, favorable controlled release function, and the like, and is suitable for batch production.
Owner:TIANJIN UNIV

Low-cost grape organic fertilizer and preparation method thereof

The invention discloses a low-cost grape organic fertilizer. The low-cost grape organic fertilizer is prepared from the following raw materials in parts by weight: 6-8 parts of eastern bracken fern rhizome residue, 30-40 parts of saw wood ashes, 6-9 parts of manganchlorite, 5-6 parts of pine needle meal, 4-5 parts of monoammonium phosphate, 5-6 parts of calcium superphosphate, 4-6 parts of potassium chloride, 6-7 parts of potassium sulfate, 5-6 parts of calcium nitrate, 5-6 parts of magnesium sulfate, 20-30 parts of plant ashes, 24-36 parts of peat soil, 12-20 parts of animal manure soil, 6-8 parts of agaricus bisporus mushroom dreg, 4-5 parts of a soil modifier and an appropriate amount of rice-washing wastewater. According to the low-cost grape organic fertilizer, the plant ashes and the peat soil can be used to optimize the soil structure; mixing and pelletizing structures such as monoammonium phosphate, potassium chloride and potassium sulfate are used, so that the fertilizer has an excellent sustained release function and can be used for providing continuous fertilizer supply for grapes; the eastern bracken fern rhizome residue and the saw wood ashes are added to strengthen permeability inside the soil and facilitate absorption of a grape root system on nutritional ingredients. The low-cost grape organic fertilizer has a very good practical value due to less consumption and high effect.
Owner:六安市叶集区富民高新葡萄种植专业合作社

PH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel and application thereof

The invention provides pH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel. A preparation method of the silver nano-cluster hydrogel comprises the following steps: (1), an AgNO3 solution is prepared, placed in a microwave reactor, stirred and heated, a cysteine solution is added dropwise, and a silver nano-cluster dispersing agent is prepared through reaction; (2), a citric acid solution is added to the silver nano-cluster dispersing agent, the mixture is placed on a small shaking table and subjected to ultraviolet irradiation, an NaHCO3 solution is added to regulate pH after the solution is transparent, high-speed centrifugation is performed, doxorubicin hydrochloride powder is added, the mixture is placed in a high-pressure reactor, nitrogen is introduced, the pressure and the temperature in the reactor are adjusted, red and clear jelly, namely, the pH-sensitive doxorubicin hydrochloride loaded silver nano-cluster hydrogel, is obtained through reaction. The silver nano-cluster hydrogel is taken as a carrier to coat doxorubicin hydrochloride and is injected to a tumor position through orthotopic injection, the pH of the tumor position is responded, so that slow drug release is realized, the tumor inhibition rate is increased, and cardiac toxicity is reduced.
Owner:JIANGNAN UNIV

Polyvinyl chloride long-acting fog-dispersal dripping agricultural film with slow-release function and preparation method thereof

The invention relates to a polyvinyl chloride long-acting fog-dispersal dripping agricultural film with slow-release function and a preparation method thereof, belonging to the technical field of agricultural films. The agricultural film is composed of the following components in parts by mass: 100 parts of polyvinyl chloride resin, 40-50 PHR of primary plasticizer, 5-10 PHR of secondary plasticizer, 1.2-3 PHR of liquid composite stabilizer, 1.2-3 PHR of powder composite stabilizer, 0.3-1 PHR of light stabilizer, 0.5-2 PHR of antioxidant, 3-5.5 PHR of fog-dispersal dripping agent, 0.007-0.3 PHR of colorant and 0.1-2 PHR of nano slow-release agent. The preparation method comprises the following steps: (1) grinding: grinding the secondary plasticizer, powder composite stabilizer, light stabilizer, antioxidant and colorant into slurry; (2) feeding of high-speed mixer: simultaneously feeding the slow-release agent and fog-dispersal dripping agent; when the high-speed mixer is at high speed, feeding the plasticizer, mixing, and feeding the ground slurry; and (3) film preparation: banburying, plastifying, calendering, setting and coiling. The agricultural film has the advantages of simple technique, favorable light transmittance, synchronous dripping fog-dispersal function period with service life of the film, and the like.
Owner:TIANJIN TIANSU SCI & TECH GROUP

Polydopamine nanocarrier delivery system for targeted activation of CD44 molecule, and preparation method and application thereof

The present invention provides a polydopamine nanocarrier delivery system for targeted activation of a CD44 molecule. According to the invention, the surface of a polydopamine nanocarrier is partiallymodified with a targeting ligand, and the targeting ligand is a ligand capable of specifically binding to the activated CD44 molecule. According to the nanocarrier and a preparation method thereof, the method is simple in process, and the nanocarrier is high in drug loading capacity, high in yield, good in adaptability to various drugs and convenient to couple with various targeting ligands. Meanwhile, the nanocarrier is endowed with a good drug sustained release function in the preparation process. The invention provides a simple method capable of realizing simultaneous synthesis and drug loading of the polydopamine nano-drug carrier through a one-pot process, wherein a drug loading procedure and the procedure of polymerizing dopamine to form the nanoparticle drug carrier are completed in one step. The method is simple, convenient, green and controllable; and the nanocarrier is high in drug loading capacity, good in compatibility with various drugs, good in biocompatibility, high insafety and easy for targeted ligand modification.
Owner:BEIJING INNO MEDICINE CO LTD

Composite drug carried microsphere, minocycline hydrochloride nano controlled-release composite drug carried microsphere system and preparation method thereof

The invention relates to a composite drug carried microsphere, a minocycline hydrochloride nano controlled-release composite drug carried microsphere system and a preparation method thereof. A drug carried system with a nuclear shell structure is formed by embedding minocycline hydrochloride inside a poly D,L-lactide-co-glycolic acid polymer microsphere and covering a cationic polymeric liposome prepared from O-QACMC modified by polyethylene glycol, O-QACMC and cholesterol outside the poly D, L-lactide-co-glycolic acid polymer microsphere; and the composite drug carried microsphere system covered and carried with the minocycline hydrochloride has the grain diameter ranging from 340 nm to 400 nm and positive surface Zeta electric potential. The composite drug carried microsphere system canbe remained in a water solution for at least 2 months, has high entrapment rate reaching larger than 90 percent on drugs and strong drug carrying capacity reaching 9 percent. The minocycline hydrochloride nano controlled-release composite drug carried microsphere system has the characteristics of uniform and controllable grain diameter, good preparation stability, simple preparation process, highdrug carrying rate, favorable controlled release function, and the like, and is suitable for batch production.
Owner:TIANJIN UNIV

Slow-release water-retaining fertilizer and preparation method thereof

The invention relates to a slow-release water-retaining fertilizer and a preparation method thereof. The slow-release water-retaining fertilizer is prepared from following components in parts by weight: 100 parts of a compound fertilizer, 10-20 parts of a water-retaining slow-release agent, 2-5 parts of an adhesive and 0.01-0.5 part of a plant growth regulator; wherein the water-retaining slow-release agent is modified montmorillonite nano powder; the preparation method of the modified montmorillonite nano powder comprises the following steps: step 1, activating montmorillonite to obtain activated montmorillonite nano powder; step 2, preparing a barbituric acid reactant; step 3, preparing an acrylic acid cross-linked barbituric acid reactant; and step 4, preparing the modified montmorillonite nano powder. The slow-release water-retaining fertilizer prepared by the invention not only has strong water absorption performance and strong water-retaining performance, but also has the effects of adsorbing heavy metals and purifying soil, greatly improves the nutrient utilization rate of the fertilizer and the utilization rate of water resources, reduces agricultural heavy metal pollution, and meets the requirements of national sustainable development strategies.
Owner:广东金正大生态工程有限公司 +1

Preparation method of metformin hydrochloride sustained-release preparation

The invention provides a preparation method of a metformin hydrochloride sustained-release preparation. The preparation method comprises the following steps: dissolving metformin hydrochloride in 95%ethanol to obtain a solution A, and adding hydroxypropyl beta-cyclodextrin and mannitol into the solution A to obtain a solution B; dissolving polylactic acid and polyethylene glycol 200 in acetone toobtain a solution C, mixing the solution B with the solution C to obtain a solution D, transferring the solution D to a magnetic stirrer, continuously stirring the solution D for 12 hours, lowering the temperature of the solution D to 0-1 DEG C within 2 hours, allowing to stand still for 12 hours, and maintaining the temperature of the solution D at 0-1 DEG C during the standing period; heating the solution D after standing till for 12 hours, continuously stirring when the temperature of the solution D is raised to 15-18 DEG C, controlling the temperature of the solution D at 15-18 DEG C whenstirring, and preparing the metformin hydrochloride sustained-release preparation with a low-temperature spray drying method after continuously stirring for 12 hours. According to the invention, thedosage of a capsule wall material is moderate, the drying temperature of materials is low, and the prepared drug-loading preparation is uniform in size and stable in drug release, and has the characteristic of slow release.
Owner:刘丽

Preparation method of vitaminB6 sustained release preparation

The invention provides a preparation method of a vitaminB6 sustained release preparation. The preparation method is characterized in that the vitaminB6 is dissolved in 95% ethanol to obtain a solutionA, and hydroxypropyl beta-cyclodextrin and mannitol are added in the solution A to obtain a solution B; polylactic acid and polyethylene glycol 200 are dissolved in acetone to obtain a solution C, the solution B and the solution C are mixed to obtain a solution D, the solution D is transferred to a magnetic stirrer, the solution D is continuously stirred for 12 hours, the temperature of the solution D is lowered to 0 DEG C to 1 DEG C in 2 hours and the solution D is subjected to standing for 12 hours, and the temperature of the solution D is kept to 0 DEG C to 1 DEG C during a standing period; after standing for 12 hours, the solution D is heated, when the temperature of the solution D is increased to 15 DEG C to 18 DEG C, the solution D is continuously stirred, when the temperature of the solution D is controlled at 15 DEG C to 18 DEG C while stirring, after the material is continuously stirred for 12 hours, the vitaminB6 sustained release preparation is prepared by a low-temperaturespray-drying method. The dosage of a capsule material is moderate, the drying temperature of the material is low, the obtained drug-loading preparation is uniform, the drug release is stable, and thevitaminB6 sustained release preparation has sustained release characteristics.
Owner:刘丽

Biochar-based organic medical fertilizer, and preparation method and application thereof

The invention relates to a charcoal-based organic medical fertilizer, and a preparation method and application thereof. The organic medical fertilizer comprises the following raw material components in percentage by weight: 0.1%-20% of thiamethoxam, 20%-80% of biomass charcoal, 10%-50% of urea and 1%-15% of an adhesive. The preparation method of the organic medical fertilizer comprises the following steps: uniformly mixing the biomass charcoal, the urea, the adhesive and the thiamethoxam to obtain a mixed material; adding water into the mixed material and uniformly carrying out stirring to obtain a water-containing material; and granulating the water-containing material, and carrying out drying to obtain the organic medical fertilizer. According to the organic medical fertilizer disclosedby the invention, thiamethoxam, biomass charcoal and urea are combined, and the three components can achieve an interaction synergistic effect, so that the insecticidal effect and fertilizer efficiency are obviously improved, and simultaneous reduction of farmland chemical fertilizers and pesticides can be achieved. Meanwhile, the lasting period of the pesticides and fertilizers can be prolonged,crop growth is effectively promoted, the crop yield is increased, and the farmland application amount and application frequency of fertilizers and pesticides can be reduced.
Owner:GUANGDONG PROVINCIAL BIOENGINEERING INST (GUANGZHOU SUGARCANE IND RES INST)
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