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Calcium carbonate particles and preparation method thereof

A technology of calcium carbonate and granules, which is applied in the field of medicine, can solve problems such as tablet hardness and disintegration uncertainty, high technical requirements for operators, and controllability of uncomfortable quality, so as to reduce the risk of cross-contamination and reduce energy consumption. consumption, good fluidity and compressibility

Inactive Publication Date: 2017-02-15
GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the amount of pregelatinized starch in the tablet exceeds 5%, and the hardness and disintegration of the tablet are uncertain, and there will be a phenomenon of high and low, and the technical requirements for operators are very high, which is not suitable for industrialization and industrialization. Requirements of Quality Controllability in GMP
And the ratio of the calcium carbonate of this invention can only reach about 90%. The preparation method is to adopt a wet granulator, through steps such as mixing, granulating, pre-drying, granulating, drying, sieving, mixing, etc., the preparation process is loaded down with trivial details, can High consumption
[0005] Chinese patent ZL 200480028609.4 describes a high-density calcium carbonate granule and a method for preparing high-density calcium carbonate. In this method, a wet granulator is used to prepare calcium carbonate granules and placed in a thermal cycle oven to dry to obtain a higher density Granules, but the particle size distribution obtained by this method is large, the compressibility is not good, and other fillers need to be added to improve, and the preparation process is cumbersome and the controllability is not good

Method used

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  • Calcium carbonate particles and preparation method thereof
  • Calcium carbonate particles and preparation method thereof
  • Calcium carbonate particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The formula composition of the calcium carbonate granule of the present embodiment is as shown in table 1:

[0031] Table I

[0032]

[0033] Preparation method: Weigh the materials according to the amounts shown in Table I, heat the purified water to 80°C, slowly add hydroxypropylmethylcellulose E50 into the hot purified water, add while stirring to obtain a binding solution, and cool to Standby at room temperature; set the inlet air temperature of the multifunctional fluidized bed (fluidized bed one-step granulator) to 60°C, and the air volume of the fan to 60m 3 / hr, preheat for 5 minutes, then add the prescribed amount of ground calcium carbonate 800 into the multifunctional fluidized bed for fluidization and preheat for 5 minutes; set the air volume of the fan to 60m 3 / hr, the air inlet temperature is 60°C, the atomization pressure is 1.6kg / ㎡, the liquid supply speed is 10rpm, and the bonding liquid is sprayed onto the calcium carbonate powder at a uniform and...

Embodiment 2

[0035] The formula composition of the calcium carbonate granule of the present embodiment is as shown in table II:

[0036] Table II

[0037]

[0038]

[0039] Preparation method: Weigh the materials according to the amounts shown in Table II, heat the purified water to about 80°C, add high-substituted hydroxypropyl cellulose ELF to the hot purified water, add while stirring to obtain a binding solution, and cool to Standby at room temperature; set the inlet air temperature of the multifunctional fluidized bed (fluidized bed one-step granulator) to 60°C, the air volume of the fan to 60m3 / hr, preheat for 5 minutes, and then add the prescribed amount of ground calcium carbonate 800 Fluidize in the multifunctional fluidized bed and preheat for 5 minutes; set the air volume of the fan to 60m 3 / hr, the air inlet temperature is 60°C, the atomization pressure is 1.6kg / ㎡, the liquid supply speed is 10rpm, and the bonding liquid is sprayed onto the calcium carbonate powder at a...

Embodiment 3

[0041] The formula composition of the calcium carbonate granule of the present embodiment is as shown in table III.

[0042] Table III

[0043]

[0044] Preparation method: Weigh the materials according to the amounts shown in Table III, add polyvinylpyrrolidone K29 / 32 into purified water, add while stirring, and wait until the solution is transparent and clear to obtain a bonding solution for use; set up a multifunctional fluidized bed (Fluidized bed one-step granulator) The air inlet temperature is 60°C, and the air volume of the fan is 60m 3 / hr, preheat for 5 minutes, then add the prescribed amount of ground calcium carbonate 800 into the multifunctional fluidized bed for fluidization and preheat for 5 minutes; set the air volume of the fan to 60m 3 / hr, the air inlet temperature is 60°C, the atomization pressure is 1.6kg / ㎡, the liquid supply speed is 10rpm, and the bonding liquid is sprayed onto the calcium carbonate powder at a uniform and constant speed through the t...

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Abstract

The invention relates to calcium carbonate particles and a preparation method thereof. The preparation method comprises the following steps: dissolving or dispersing an adhesive into a solvent to obtain adhesion liquid which is selected from at least one of hydroxypropylmethyl cellulose, high-substituted hydroxyproxyl cellulose, polyvinylpyrrolidone, sucrose, starch, sodium carboxymethylcellulose, methyl cellulose and ethyl cellulose; fluidifying calcium carbonate in a fluidized bed and preheating, wherein the calcium carbonate is ground calcium carbonate of which the median size is 0.1-20 mu m, and the mass ratio of the calcium carbonate and the adhesive is 10-50:1; spraying the adhesion liquid on the preheated calcium carbonate, and pelletizing on the fluidized bed and drying; and granulating to obtain the final product. The calcium carbonate particles which are prepared by the preparation method are good in fluidity, good in compressibility and good in firmness, and can be directly used for vertical tabletting; other filler auxiliary materials are not required to be added during tabletting; and the pressed tablets are small in size and are orally taken conveniently.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a calcium carbonate particle and a preparation method thereof. Background technique [0002] Calcium is the most abundant metal element in the human body, about 1200 grams, and it is also one of the most easily deficient elements. 99% of them are formed in bone, and 1% exist in blood soft tissue. Whether the human body is deficient in calcium is related to two reasons: one is the peak bone mass, that is, the calcium content when the human bone mass reaches the highest bone mass in life at the age of 35, which is mainly determined by genetic factors, calcium supplementation factors and exercise factors The second is the loss of calcium, which is determined by calcium supplementation, loss and living habits, such as smoking and drinking, coffee, tea, cola, excessive salt intake, eating less meat or eating too much meat can lead to calcium loss. drain. my country is a country wh...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K33/10A61K47/38A61K47/36A61K47/32A61K47/26A61P3/02A23G3/42A23G3/36
CPCA61K9/1652A23G3/364A23G3/42A23V2002/00A61K9/1635A61K33/10A23V2200/30A23V2250/51082A23V2250/628A23V2250/5118A23V2250/51088A23V2250/1578
Inventor 吴传斌陈航平李革潘文杰杨思超胡春丽张林杰
Owner GUANGZHOU ZHONGDA NANSHA TECH INNOVATION IND PARK
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