50 results about "Fluid Bed Granulation" patented technology

A preparation technology of amlodipine besylate is disclosed in the present invention, the technology is with amlodipine besylate, filler, disintegrating agent, lubricant etc. as main components. By using grinding and sieving; reasonably controlling particle water; repeatedly feeling fluidized bed granulating technology parameter, controlling spraying speed, spraying pressure and air quantity, under the situation of non-affecting tablet content and hardness, increasing the solubility of product greatly, thereby promoting the internal quality and curative effect of the product.

A process for the production of granular detergent compositions is provided wherein fluid bed granulation is employed in conjunction with selected recycle of oversized particles to control the uniformity of the resulting detergent composition. The process comprises feeding starting ingredients into a fluid bed granulator to at least partially granulate the feed material while employing the fluid bed to control undersized particle generation and sizing in conjunction with recycle to control oversized particles.

Fluid bed granulation process comprising the step of cooling the granules in a cooling fluid bed (F2). At least part of the fluidizing air coming out from said cooling fluid bed (F2) is fed into the granulation fluid bed (F1).

A fluid bed granulation process of a predetermined substance comprises the steps of: forming, through a fluidification. air flow of predetermined flow rate, a fluid bed of granules of said substance to be granulated fed to it in the form of seeds, —feeding said fluid bed with a continuous flow of a growth substance (or liquid).

A fluid bed granulation process for manufacturing non-hygroscopic, stable granulates containing a water-soluble salt of S-adenosylmethionine is described. Said process comprises:a) the simultaneous, sequential or alternate dispersion of at least a solution of a water-soluble salt of SAMe (A) and of a solution of a coating agent (B), on a fluid bed granulation carrier (C) andb) the fluid bed granulation of the mixture.Granulates obtainable by said process and solid oral pharmaceutical forms obtainable by said granulates are disclosed.

A method for the preparation of homogenous microparticles containing a H<+>, K<+>-ATP-ase inhibitor using a fluid-bed granulation technique. The microparticles that have a desired size distribution are selected. At least 80% of the microparticle based on its dry weight content is the acid labile H<+>, K<+>-ATP-ase inhibitor.

A process for obtaining finished granules of a predetermined substance in a granulation fluid bed (F1) of the so-called vertical growth type, the bed being formed and maintained by a respective flow of fluidification air, comprises a transfer phase by falling of the finished granules in a pressurized space below the granulation bed and a recovery phase of the finished granules from the pressurized space.

In order to produce granules granulometrically polidispersed in a very little range, a fluid bed granulation process of the type comprising the steps of preparing a fluid bed of seeds (S1) of the substance to be granulated, having a free surface (P) substantially horizontal; and feeding a continuous flow (L) of a fluid comprising a growth liquid, provides in the fluid bed for a continuous vortex (V) with a substantially horizontal axis, in which an upper zone (Z1) of seeds wetting and evaporation of possible solvent contained in the flow (L) and a lower zone (Z2) of solidification / consolidation of the growth liquid are identified.

The invention relates to the technical field of biopesticides, and particularly relates to a granule virus dry suspending agent and a preparing method thereof. The dry suspending agent is mainly prepared by subjecting a granule virus aqueous suspending agent to pressurized spray drying and fluid-bed granulation, wherein a hot-wind inlet temperature of spray drying is 130-150 DEG C, an outlet temperature is 70-90 DEG C, and the temperature of a fluid bed is 50-70 DGE C. The granule virus aqueous suspending agent comprises a spray drying protective agent. Through setting temperature parameters of spray drying, and combining the spray drying protective agent added into the granule virus aqueous suspending agent, preparation of the dry suspending agent by adopting a spray drying wet-method granulation process is achieved, defects of dry-method granulation are overcome, the prepared dry suspending agent has high pest killing activity, good suspension, dispersing and disintegration properties, the suspending rate of the dry suspending agent is greater than 85%, dispersibility of the dry suspending agent is greater than 85%, the dry suspending agent has loose granules and is easy to disintegrate, and killing toxicity for corresponding pests can be 90% or above.

The invention discloses inflammation diminishing capsules prepared from baical skullcap root and golden thread and a preparation method thereof. The method is characterized in that a granulating process adopts spray drying one-step granulating technology, liquor is used as adhesive, the medicinal powder is blown to be stuck with the liquor together and directly prepared into dry grains with even size, and the dry grains are filled into capsules. The process of one-step granulating technology comprises the following steps: weighing a proper amount of baical skullcap root powder serving as an auxiliary material and feeding the baical skullcap root powder into a fluidized bed granulating chamber of a spray drying granulator, and blowing hot air into the fluidized bed granulating chamber to preheat the baical skullcap root powder; starting an air blower to make the air enter the granulating chamber through a filter device and a heat exchanger from an air inlet, make a negative pressure formed in the granulating chamber, and make the medicinal powder float up and down for preheating and drying; spraying a proportional quantity of medicinal extract concentrated solution to the granulating chamber through a spray nozzle to form fog drops, and agglomerating the fog drops and the baical skullcap root powder to form porous grains; blowing the hot air to dry the grains while spraying, and vibrating a powder catching bag at regular intervals; and repeating the operation till the specified amount of medicinal extract concentrated solution is completely sprayed. The method is suitable for the preparation and production of the inflammation diminishing capsules prepared from the baical skullcap root and the golden thread.

A fluid bed granulation process and apparatus, wherein a suitable fluid bed of a particulate material is maintained in a granulator (1) fed by an input flow (F) comprising a growth liquid (L) and by a flow (S1) of seeds adapted to promote the granulation, and wherein a part (F2) of said input flow (F) is taken upstream the feeding of the fluid bed, and used in a seeds generator (33), to produce the seeds for the fluid bed.

A process for preparation of a granular urea product by granulating a urea solution in a fluidized bed, where the granulation process takes place along a substantially longitudinal growth path, from a granulation starting end (1s) to a product discharge end (1E) of said fluidized bed, and said urea solution enters the fluidized bed by means of several urea inputs (2A, 2B, 2C) taken from a main urea feed (2), where an additive (6) is mixed with said urea solution said additive has a non-uniform concentration in said urea inputs, so that at least two of said urea inputs have a different concentration of additive.

A standardized, edible food containing a label for use in the measurement of gastric emptying by the quantification of marker excreted in the breath of the patient and methods of making the same using fluid bed granulation processing.

Fluid bed granulation process of an appropriate substance, comprising the cooling in a second fluid bed of the granules obtained. The same flow of fluidification air is used to form and support both fluid beds.

In order to produce granules granulometrically polidispersed in a very little range, a fluid bed granulation process of the type comprising the steps of preparing a fluid bed of seeds (S1) of the substance to be granulated, having a free surface (P) substantially horizontal; and feeding a continuous flow (L) of a fluid comprising a growth liquid, provides in the fluid bed for a continuous vortex (V) with a substantially horizontal axis, in which an upper zone (Z1) of seeds wetting and evaporation of possible solvent contained in the flow (L) and a lower zone (Z2) of solidification / consolidation of the growth liquid are identified.

Fluid bed granulation process comprising the step of cooling the granules in a cooling fluid bed (F2). At least part of the fluidizing air coming out from said cooling fluid bed (F2) is fed into the granulation fluid bed (F1).

A fluid bed granulation process and apparatus, wherein a suitable fluid bed of a particulate material is maintained in a granulator (1) fed by an input flow (F) comprising a growth liquid (L) and by a flow (S1) of seeds adapted to promote the granulation, and wherein a part (F2) of said input flow (F) is taken upstream the feeding of the fluid bed, and used in a seeds generator (33), to produce the seeds for the fluid bed.

A process for obtaining finished granules of a predetermined substance in a granulation fluid bed (F1) of the so-called vertical growth type, the bed being formed and maintained by a respective flow of fluidification air, comprises a transfer phase by falling of the finished granules in a pressurized space below the granulation bed and a recovery phase of the finished granules from the pressurized space.

A fluid bed granulation process of a predetermined substance comprises the steps of: forming, through a fluidification. air flow of predetermined flow rate, a fluid bed of granules of said substance to be granulated fed to it in the form of seeds,—feeding said fluid bed with a continuous flow of a growth substance (or liquid).

The invention discloses a trospium chloride composition and a preparation method thereof. The trospium chloride composition comprises, by weight, 2-10 parts of trospium chloride serving as an active ingredient, 80-200 parts of diluent, 1-20 parts of adhesion agent and 1-5 parts of antisticking agent. The trospium chloride composition has the advantages that by means of reasonable proportioning of the diluent and the adhesion agent, the composition can disperse in the stomach rapidly after being taken orally and floats partially to release medicine slowly, so that on one hand, stable blood concentration can be kept, adverse reaction incidence is decreased, and medication safety is improved; on the other hand, stopping time of the medicine in a gastrointestinal tract is prolonged, bioavailability is increased, therapeutic effects are improved and cost is saved. The preparation method of the trospium chloride composition has the advantages that a fluid-bed granulation technology is adopted to enable granulation to be completed at a step, so that time is saved, efficiency is improved and production cost is reduced greatly.

The invention discloses a spiral fluidized bed granulating method and equipment for realizing the spiral fluidized bed granulating method. The spiral fluidized bed granulating method comprises the following steps: A. melting granulating adhesive; B. mixing materials, heating and conveying to a spiral fluidized bed unit; C. granulating; D. screening granulated materials in the step C; and E. collecting dusts. The equipment for realizing the spiral fluidized bed granulating method comprises a granulating adhesive melting and conveying device, a material mixing, heating and conveying device, a granulating device, a screening device and a dust collecting device. The spiral fluidized bed granulating method and the equipment have the beneficial effects that a mechanical method is adopted to perform powdery material granulation, and the method and the equipment can be suitable for powdery material granulation, can overcome the defect that the traditional fluidized bed adopts wind powder as power and is not suitable for powdery material granulation, and can reduce dust pollution.

Fluid bed granulation process comprising the steps of: -forming a fluid bed of seeds (S1) of a chosen substance, -feeding said fluid bed with a continuous fluid flow (L) comprising a growth liquid, -inducing and maintaining a continuous vortex (V) in said fluid bed, the vortex (V) having a substantially horizontal axis, characterized in that said fluid flow (L) is fed into predetermined first zones (Z1) of said fluid bed, said first zones (Z1) being alternated to second zones (Z2) of said fluid bed in which said fluid flow (L) is not fed.

The invention provides a preparation method of gemifloxacin mesylate medicinal composition with large medicine loading capacity. The preparation method comprises a wet-method grain pre-manufacturing step and a fluidized bed grain manufacturing step. According to the preparation method of the gemifloxacin mesylate medicinal composition, disclosed by the invention, the wet-method grain pre-manufacturing step and the fluidized bed grain manufacturing step are combined, a suitable amount of disintegrating agents, and lubricant and the like are externally added after grains are dried and finished so that the gemifloxacin mesylate medicinal composition is pressed into tablets. The gemifloxacin mesylate tablets obtained by the preparation method disclosed by the invention avoids adverse factors of weight variation of pressed tablets influenced by grain unevenness generated because materials are adhered on the wall of a granulator during a wet-method grain manufacturing step or the fluidized bed grain manufacturing step, low grain yield after the materials are adhered on the wall of a granulator, and the like.

A nozzle for distributor devices of granule's growth liquid substance in fluid bed granulators, is distinguished by the fact that it comprises a duct (2) having, at one end, at least one inlet opening (3) for a flow (F) of a chosen granule's growth liquid substance, and, at the other end, a supply opening (5) for such substance, a gaseous flow distributor (6) externally associated to the duct (2) in predetermined spaced relationship from the supply opening (5) and in fluid communication with the inside of the duct (2), and emulsifying means (8) associated to the inlet opening (3) and the distributor (6) to obtain, inside the duct (2), an emulsion of the gaseous flow in the growth liquid substance.