Acetaminopher DC90 fine particle and preparation method thereof

A technology of acetaminophen and fine particles, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, and drug combinations, etc. It can solve the problems of uneven content of active ingredients, difficulty in mixing uniformly, and large accumulation ratio to achieve flow Good resistance, good compressibility, and small bulk specific gravity

Active Publication Date: 2009-01-14
ANQIU LUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the large particle size of the original DC90 granules and the relatively large bulk specific gravity, it is not easy to mix evenly when adding a small amount of other active ingredient powders for mixing, resulting in uneven content of active ingredients in the final compressed tablet

Method used

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  • Acetaminopher DC90 fine particle and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment

[0036] Embodiment: material proportioning:

[0037] Acetaminophen 310kg;

[0038] Corn starch 12.05kg;

[0039] Pregelatinized starch 12.05kg;

[0040] Povidone 6.90kg;

[0041] Crospovidone 1.72kg;

[0042] Stearic acid 1.72kg.

[0043] Preparation method: the specific process steps are as follows:

[0044] a) Ingredients: 310kg of acetaminophen and 12.05kg of cornstarch are packed into a batching tank and mixed evenly;

[0045] b) Feed material: Turn on the induced draft fan, set the inlet air temperature to 55°C and the air volume to 10000m 3 / h, spray pressure 2.0bar, suck the material from the batching tank into the material tank of the granulator;

[0046] c) Fluidized mixing: when the air inlet temperature is 55°C, the air volume is 1000m 3 / h, under the condition of spray pressure 2.0bar, fluidized and mixed for 5 minutes, stand-by;

[0047] d) Slurry preparation: add 12.05Kg of pregelatinized starch and 6.90Kg of povidone in sequence into the slurry tank of 1...

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PUM

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Abstract

The invention discloses paracetanol DC90 fine particles and a preparation method thereof. The paracetanol DC90 comprises following materials by weight ratio: 90 percent of paracetanol, 3.50 percent of cornstarch, 3.50 percent of pre gelatinized starch, 2.00 percent of povidone, 0.5 percent of crospovidone and 0.5 percent of stearic acid. Firstly, the paracetanol and the cornstarch are mixed evenly, then the pre gelatinized starch and the povidone are made into starch slurry to be used as bond which is evenly sprayed on the mixture of the fluidied paracetanol and cornstarch, fluidized bed granulation is carried out in the inlet air temperature, the wet particles are dried under the temperature of 80 DEG C and then are cooled at the temperature of 50 DEG C till water conforms to the requirement, the sizes of the particles are adjusted, the stearic acid and the crospovidone are added after the particle sizes are adjusted to be mixed evenly to obtain the paracetanol DC90 fine particles. The invention adopts the above technical proposal to inspect the product, and the particles are fine and uniform and have favorable fluidity, thereby being well and evenly mixed with other small quantities of active components powder.

Description

technical field [0001] The present invention relates to the formulation and preparation method of acetaminophen DC90 fine particles Background technique [0002] Paracetamol DC90 granule, its main active ingredient is 90% paracetamol, 10% is other additives. [0003] The main function of this product is antipyretic and analgesic. It acts on the body temperature center and is used for headache, fever, joint pain, neuralgia and dysmenorrhea. [0004] This product can be directly filled into capsules or directly compressed into tablets. However, with the demand of the current international market, some customers want to add other active ingredients to the granule to make a compound preparation to increase its curative effect. However, since the original DC90 granules have a large particle size and a relatively large bulk specific gravity, it is not easy to mix evenly when adding a small amount of active ingredient powder, resulting in uneven content of the active ingredient i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/167A61P29/00
Inventor 刘国贞李庆文王涛
Owner ANQIU LUAN PHARMA
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