The invention discloses an anti-seismic intelligent box-type substation which includes a base, a fixing device, a positioning device, a frame body, a control device, a cover plate device and an air inlet device, wherein positioning rods and first fastening devices are arranged on the base; each first fastening device includes an upper end part and a lower end part, and a first through hole is formed in the upper end part; the fixing device includes a support plate, vertical rods, support blocks and first springs; the positioning device includes second springs and ejection devices; each ejection device includes fixing rods, a third spring, a movable block, a connecting rod, a rectangular block and a friction block; a third through hole, triangular blocks, a humidity sensor, a temperature sensor and a fourth through hole are arranged in the frame body; the control device includes a control box, a display screen, a circuit board, a processor, a memory, a power supply and a signal transceiver module. The anti-seismic intelligent box-type substation provided by the invention has relatively good anti-seismic property and good anti-seismic effect; even an earthquake occurs, the electrical components inside the substation can be effectively protected, and damages to the electrical components due to shock are prevented.