The invention provides a strong-effect antibacterial wear-resistant brush wire and a preparation method thereof, and relates to the technical field of plastic brush wire processing. The strong-effectantibacterial wear-resistant brush wire is prepared by the following raw materials in parts by weight: 18-22 parts of polypropylene resin, 12-16 parts of phenolic resin, 8-10 parts of low density polyethylene resin, 2-3 parts of trimesic acid, 1-2 parts of activated alumina, 1-3 parts of shell activated carbon, 2-4 parts of nano titanium dioxide, 2-3 parts of N,N-dimethylacetamide, 2-3 parts of ethylenediaminetetraacetic acid, 1-3 parts of glass fiber, 2-3 parts of stilbite, 2-3 parts of an antibacterial agent, 1-2 parts of a toughening agent, and 2-3 parts of a crosslinking agent. Deficiencies of the prior art are overcome, mixed preparation of various raw materials is adopted, the antibacterial property of the brush wire is effectively improved, and damage caused by bacterial aggregationon the brush wire is prevented. At the same time, wear resistance of the brush wire is improved, the service life of the brush wire is enhanced, and economic benefits are improved.