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Iodine-supported skin bactericide and iodine supporting method

A bactericide and skin technology, applied in the field of medicine, can solve the problems of small radius, difficult release, skin irritation, etc., to achieve the effect of safe and reliable use, green process and easy storage in large quantities

Inactive Publication Date: 2016-03-30
上海复榆医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both have a certain stimulating effect on the skin and are not suitable for disinfection of damaged skin, eyes and oral mucosa.
Exchangeable Ca in balance with the negative charge carried by the framework aluminum +2 The number of ions is half of the skeleton aluminum, Ca +2 The ionic radius is small, the electrical property is strong, and its polarizing force is very strong. Iodine molecules are in the Ca +2 Surrounded by it, it is quite difficult and slow to release from the pores and cages of A zeolite, making its disinfection effect slower

Method used

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  • Iodine-supported skin bactericide and iodine supporting method
  • Iodine-supported skin bactericide and iodine supporting method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1, from iodine vapor phase adsorption loading iodine

[0021] in a Place solid pure iodine crystals in the branch tube closed at the bottom on one side of the trident-shaped glass tube, and put powdery or granular (spherical) carriers in the branch tube closed at the bottom on the other side. The trident tube is placed in a constant temperature water bath to maintain a certain load temperature. The iodine vapor produced by the sublimation of iodine crystals diffuses into the other connected branch pipe and is adsorbed by the carrier. The iodine-loaded sample was adsorbed at a certain temperature for a certain period of time, and its iodine loading was measured by X-ray fluorescence spectrometer (XRF).

[0022] Adsorption atmosphere control: air-atmospheric pressure; vacuum-pressure 0.1 Torr. The load test results are shown in Table 1 below.

[0023] Table 1

[0024] .

Embodiment 2

[0025] Embodiment 2, from the KI aqueous solution that is dissolved with iodine, adsorption load iodine

[0026] Pour the KI solution containing a certain amount of iodine into a glass container, then weigh a certain amount of carrier and put it into the container. The container is placed on a heating plate of a heatable and temperature-controlled electromagnetic stirrer. Under the condition of vigorous stirring, the nanometer microporous loading material suspended in the solution can rapidly absorb the dissolved elemental iodine in the solution. After the loading test, after filtering, washing with deionized water, rinsing with acetone, and drying in the air at room temperature for 1 hour, the iodine loading was determined by XRF method. The test results are shown in Table 2 below.

[0027] Table 2

[0028] .

Embodiment 3

[0029] Embodiment 3, antibacterial effect detection

[0030] Pick Staphylococcus aureus and incubate in 1ml TSB medium at 37°C and 200rpm for 18h. Dilute the bacterial solution to 3-7×10 5 CFU / ml, poured into Petri dishes, 5ml per dish, left for 30min, poured out the bacterial solution, and dried. The bactericidal powder containing iodine 2.5 loaded with STI zeolite in the present invention is mixed with TSB medium, and diluted in multiples, and the concentrations are 500mg / ml, 250mg / ml, 125mg / ml, 62.5mg / ml, 31.75mg / ml, 15.88mg / ml, 7.94mg / ml, 3.96mg / ml. Put the paper pieces into the petri dish, 6 pieces per dish, add 6 μl each of iodine-containing fungicide powder, Aner’s iodine, TSB medium and iodine-free STI mineral powder to the paper pieces in a separate petri dish, each The concentration of iodine-containing bactericidal powder in a petri dish is unique. Incubate at 37°C for 18 hours, and observe the size of the inhibition zone. The results showed that three bacteric...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to an iodine-supported skin bactericide and an iodine supporting method. The iodine-supported skin bactericide is formed by supporting iodine on a modified natural mineral zeolite molecular sieve which is used as a supporter. The iodine accounts for 1-15 wt% of the supporter. The supporter comprises STI stilbite, MOR mordenite and HEU clinoptilolite. The iodine supporting method is implemented by supporting the simple substance iodine in a vapor phase or supporting the iodine from an iodine-containing KI water solution. The iodine-supported skin bactericide can take effect quickly and can not burn the skin to cause pains when in use. The iodine-supported skin bactericide can be prepared into powder or granules. The iodine-supported skin bactericide is safe, reliable, green and environment-friendly, and is convenient for abundant storage, carrying and transportation. The production technique of the bactericide is simple, and the process is green and environment-friendly.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an iodine-loaded skin fungicide and an iodine-loaded method. Background technique [0002] Tincture of iodine and tincture of iodine are commonly used liquid skin antiseptics. The former is made by dissolving iodine and potassium iodide in alcohol solution, and the iodine concentration of commercially available iodine is 2%. The latter is an amorphous combination of elemental iodine and polyvinylpyrrolidone (Povidone), and medical iodophors contain 1% or less of iodine. Both have a certain stimulating effect on the skin and should not be used for disinfection of damaged skin, eyes and oral mucosa. Iodine with alcohol as a solvent is flammable, and it is dangerous to store and transport in large quantities. The solvent polyvinylpyrrolidone of iodophor is a nitrogen-containing organic small molecular compound, which will cause certain pollution to the environment if...

Claims

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Application Information

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IPC IPC(8): A61K33/18A61K47/02A61P31/02
CPCA61K33/18A61K47/02
Inventor 蔡国君毕宏达张恩晖林德昌龙英才
Owner 上海复榆医药科技有限公司
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