103results about How to "No obvious toxic reaction" patented technology

The invention discloses an application of in-situ crosslinking hydrogel in preparing artificial vitreous bodies, which is characterized in that the in-situ crosslinking hydrogel is prepared by in-situ crosslinking after mixing a four-arm-end mercapto polyethylene glycol solution shown in the formula (I) and a polymer solution shown in the formula (II); wherein m in the formula (I) is an integer larger than 1, and n in the formula (II) is an integer larger than 1; and the two solutions are filled in eyes without vitreous bodies after mixing and can effectively form gel. A cell experiment and an animal in vivo experiment prove that the in-situ crosslinking hydrogel does not cause obvious inflammatory reaction and intraocular organ toxic reaction and can be used as the artificial vitreous bodies.

The invention relates to a traditional Chinese medicine composition for invigorating the kidney, strengthening yang, replenishing essence, and reinforcing vitality, and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following thirty five traditional Chinese medicines: cynomorium songaricum, rhizoma curculiginis, morinda root, Angelica sinensis, fructus cnidii, broomrape, Chinese chive seed, Chinese magnoliavine fruit, red ginseng, bull penis, dog kidney, antler, black sliced aconite, cinnamon, common fennel, actinolite, pepper, dodder, eucommia, flasem milkvetch seed, Codonopsis pilosula, cornel, herba epimedii, Astragalus root, Chinese yam, prepared rehmannia root,fructus psoraleae, wolfberry fruit, raspberry, polygala, lotus stamen, cherokee rose, rhizoma alismatis,licorice and tuckahoe. The traditional Chinese medicine composition has the efficacies of invigorating the kidney, strengthening yang, replenishing essence, and reinforcing vitality, is mainly used for the diseases of insufficiency of impotence, spermatorrhea, prospermia and the like caused by the kidney-yang or deficiency of the kidney-yin, has remarkable clinical pharmacodynamic testing effect, is high in bioavailability, and has not any toxic or side effect.

The present invention relates to a traditional Chinese drug composition for blood cooling, hemostasis, yin nourishing, blood stasis dissipating, liver nourishing and eyesight improving, and a preparation method thereof. The traditional Chinese drug composition is prepared from the following nineteen traditional Chinese drugs: cattail pollen, salvia miltiorrhiza, rehmannia, eclipta, chrysanthemum, baikal skullcap root (charred radix scutellariae), obtuseleaf senna seed, asiatic plantain seed, common motherwort fruit, glossy privet fruit, common selfheal spike, Chinese gentian root, wenchow turmeric root tuber, common scouring rush, red peony root, tree peony root-bark, hawthorn, angelica and szechwan lovage rhizome. The traditional Chinese drug composition has effects of blood cooling, hemostasis, yin nourishing, blood stasis dissipating, liver nourishing and eyesight improving, and is mainly applicable for yin deficiency, liver hyperactivity, and subhyaloid hemorrhage caused by collateral thermal injury. Compared to the prior art, the clinical pharmacodynamics test effects of the traditional Chinese drug composition provided by the present invention are significantly increased, the bioavailability of the traditional Chinese drug composition provided by the present invention is high, and the traditional Chinese drug composition provided by the present invention does not cause any toxic and side-effect.

The diarrhea treating Chinese medicine composition is prepared with Chinese goldthread, skullcap root, white peony root, patchouly, guava leaf and tuckahoe as material. It has the functions of clearing away heat and toxic material, moisturizing and stopping diarrhea, and can kill diarrhea causing pathogenic bacteria and viruses to cure acute infectious diarrhea in high efficiency, quickly and safely.

The invention provides a composition comprising biologically active components as follows: 100 weight parts of pearl, 15 to 300 weight parts of gyrophora and 15 to 300 weight parts of ganoderma spore powder. A preparation method and application of the composition are provided by the invention.

The invention applies to the technical field of biological medicine and provides a method for infecting infecting mesenchymal stem cells by Runx2 recombinant lentiviruses to express osteoblastic genes. The method comprises steps as follows: Runx2 gene extraction and plasmid construction are performed; the Runx2 recombinant lentiviruses are packaged; the Runx2 recombinant lentiviruses infect the mesenchymal stem cells, so that infected mesenchymal stem cells capable of expressing the osteoblastic genes are obtained.

The invention relates to a compound medicament for treating diabetes and nephrosis and process for preparation, wherein the raw materials include Chinese medicinal herbs of astragalus root, dried rehmannia root, selfheal, zedoary, winged euony twigs and right amount of starch gum.

The invention relates to a blood-nourishing and eyesight-improving Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition is prepared from 19 kinds of traditional Chinese medicines such as cattail pollen, red-rooted salvia root, rehmannia root, yerbadetajo herb, chrysanthemum, baical skullcap root (carbon), cassia seed, plantain seed, motherwort fruit, glossy privet fruit, common selfheal fruit-spike, Chinese gentian, turmeric root-tuber, common scouring rush herb, red paeony root, tree peony bark, hawthorn, Chinese angelica and szechuan lovage rhizome. The Chinese medicinal composition has the effects of cooling blood, relieving bleeding, nourishing yin, dissolving stasis, nourishing liver and improving eyesight, is mainly used for treating fundus hemorrhage caused by deficiency of yin, syndrome of liver and thermal burn of collaterals, and has a remarkable clinical pharmacodynamic study effect, high bioavailability and no toxic or side effect.

The invention relates to a Chinese medicinal composition for treating constipation, acne and hyperlipidemia, and a preparation method. The Chinese medicinal composition is prepared from the following Chinese medicines: rhubarb, rhizoma atractylodis macrocephalae, American ginseng, mirabilite, immature bitter orange, cynanchum otophyllum, root of Yunnan madder, cistanche deserticola and lotus leaf; and the Chinese medicinal composition has the effects of supplementing qi and activating blood circulation, and relaxing the bowels and expelling toxin, and is mainly used for treating qi deficiencyto blood stasis, pyretic toxicity accumulated inside, constipation, acne, color spots, and hyperlipidemia. Compared with the prior art, the Chinese medicinal composition has the advantages that: the formula of the Chinese medicinal composition is reasonable, the test effect of the clinical pharmacodynamics is obviously improved, and the Chinese medicinal composition has high bioavailability and does not have any toxic or side effect.

The invention discloses an in-situ crosslinked hydrogel for intraocular tamponade, and a preparation method and an application thereof. The preparation method comprises a step that the hydrogel is obtained through an in-situ crosslinking reaction of 4arm-PEG-thiol having a structure represented by formula (I) shown in the specification and a polymer having a structure represented by formula (II). The invention also provides an application of the in-situ crosslinked hydrogen prepared through the method in the preparation of artificial vitreous bodies. Compared with traditional artificial vitreous body substitute materials, the in-situ crosslinked hydrogel which is the artificial vitreous body substitute material provided by the invention has the advantages of long-term intraocular tamponade, and no obvious toxic reactions, stimulates an original natural vitreous body structure, and is hydrophilic.

The invention relates to blood platelet raising capsules, namely a Chinese herbal combination, and a preparation method of the capsules. The Chinese herbal combination is prepared from five traditional Chinese medicines including indigo naturalis, fructus forsythia, hairyvein agrimony, moutan bark and liquorice. The Chinese herbal combination has effects of clearing away heat and toxic materials,cooling blood for hemostasis, dissipating stasis and eliminating ecchymosis, and is mainly applied to primary thrombocytopenic purpura which has the symptoms of petechia or ecchymosis all over the body, having a fever, polydipsia, scanty dark urine, constipation, or epistaxis, gum bleeding, red tongue, yellow coated tongue, and slide number or string number of vessels. The blood platelet raising capsules have remarkable test results of clinical pharmacodynamics and high biological availability, and are free from any toxic and side effect.

The invention is suitable for the field of biological medicines, and provides a constructing method of a bone marrow stem cell expressing an osteogenic gene. The method utilizes a lentivirus carrying a hypoxia-inducible factor 1alpha to infect a bone marrow stem cell and to express the osteogenic gene. The method includes following steps: constructing a lentivirus expression vector Lenti-HIF-1alpha-eGFP; packaging the lentivirus expression vector Lenti-HIF-1alpha-eGFP carrying the hypoxia-inducible factor 1alpha; and infecting the bone marrow stem cell with the lentivirus expression vector Lenti-HIF-1alpha-eGFP to obtain the infected bone marrow stem cell capable of expressing the osteogenic gene.

The invention relates to a traditional Chinese medicine composition for treating neurasthenia, and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following sixteen traditional Chinese medicines: steamed sealwort, epimedium, wolfberry fruit, antler, deerhorn glue, deglued deerhorn, red ginseng, pitted jujube, tuckahoe, ophiopogon root, tortoise shell, fried wild jujube seed, magnolia vine fruit, prepared polygala root, prepared rehmannia root and cocklebur fruit. The traditional Chinese medicine composition has the efficacies of strengthening bymeans of tonics and tranquilizing and allaying excitement, and is mainly used for treating neurasthenia, headache, dizziness, amnesia, insomnia, tinnitus and the like. Compared with the prior art, the traditional Chinese medicine composition has a more reasonable process, high bioavailability, good drug stability and no toxic side effects, and is notably improved on the clinical pharmacodynamic testing effects.

The invention relates to a traditional Chinese medicinal composition for treating diabetes mellitus and a preparation method thereof. The traditional Chinese medicinal composition is prepared by ten types of traditional Chinese medicines: coptis chinensis, phellodendron bark, ginseng, giant knot weed, salvia miltiorrhiza, astragalus mongholicus, cortex lycii radicis, rhizoma anemarrhenae, radix scrophulariae and rhizoma atractylodis and the like. The traditional Chinese medicinal composition is used for nourishing yin and clearing heat, tonifying qi and yin, activating blood and removing stasis, invigorating the spleen and tonifying the kidney, and mainly treats the diabetes mellitus caused by dryness-heat unbalance, weakness of the spleen and the kidney, blood stasis of collaterals and the like. In the invention, the clinical pharmacodynamic test effect is obviously improved, the process is advanced, the preparation method is simple and convenient, the content of effective ingredients is high, the preparation stability is good, the curative effect is obvious and no any toxic and side effect is caused.

The present invention provides one medicine composition for treating coronary heat disease ventricular premature beat based on the Chinese medicine theory of benefiting vital energy, nourishing Yin, promoting blood circulation, dredging meridian, clearing away heat-evil in the pericardium and tranquilizing. The medicine composition has 12 kinds of Chinese medicinal materials including ginseng, ophiopogon root, dogwood, red sage, common jujube seed, etc. The pharmacological test shows that the composite medicine capsule has obvious effect of preventing mouse's arrhythmia caused by CaCl2 and decreasing the sustained time of rat's arrhythmia caused by aconitine.

The invention discloses a traditional Chinese medicine eye drops used for treating acute conjunctivitis and a preparation method thereof. The traditional Chinese medicine eye drops are processed and prepared from honeysuckle flower, mulberry leaf and wild chrysanthemum flower in certain proportion, have the effects of clearing away heat and toxic materials, eliminating red and reducing swelling and are applicable to treatment of the acute conjunctivitis. Compared with the prior art, the traditional Chinese medicine eye drops have the advantages that a process is advanced, a clinical pharmacodynamic experiment effect is more remarkable, biological availability is high and no toxic or side effect is produced.

The invention relates to a traditional Chinese medicine composition for promoting blood circulation to stop pain and eliminating blood stasis and promoting tissue regeneration, and a preparation method thereof. The traditional Chinese medicine composition is prepared from six traditional Chinese medicines namely pseudo-ginseng, ligusticum wallichii, radix angelicae, angelica sinensis, ground beeltle and flowers carthami. The drug has the effects of promoting blood circulation to stop pain and eliminating blood stasis and promoting tissue regeneration, is mainly used for treating traumatic injury, hemostasis swelling pains of muscles and bones, and rheumatic numbness. A clinical pharmacodynamic experiment shows that the traditional Chinese medicine composition is significant in effect, high in bioavailability and free of toxic and side effects.

The invention discloses a Chinese medicine composition used for tonifying qi and spleen, tonifying kidney and calming heart and a preparation method thereof. The Chinese medicine composition is made by processing American ginseng, herba epimedii and schisandra chinensis in certain proportion. The Chinese medicine composition is applicable to deficiency of both qi and yin, fatigued spirit caused by deficiency of heart and kidney, dizziness and insomnia, spontaneous perspiration and palpitation, soreness and weakness of waist and knees and the like. Compared with the prior art, the Chinese medicine composition has the advantages that a clinical pharmacodynamic experiment effect is more remarkable, the biological availability is high and no toxic or side effect is produced.

The invention discloses a Chinese traditional medicine composition for clearing retardation, promoting the subsidence of swelling and alleviating pain and a preparation method thereof. The Chinese traditional medicine composition is prepared from folium sennae, colchicum autumnale, medicine terminalia fruit, operculina turpethum, almond, saffron and the Secretary ComforSpin Virginia fat in certain proportion. Compared with the prior art, the Chinese traditional medicine composition is more reasonable in formula and remarkable in curative effect, has the effects of clearing retardation, promoting the subsidence of swelling and alleviating pain, and is used for treating articular pain, rheumatism, rheumatoid arthritis and sciatica. The Chinese traditional medicine composition and preparation method thereof have the advantages of reasonable formula, advanced technique, remarkable curative effect and no toxic side effect.

The invention relates to application of Leontopodic acid and a plant extract and a composition containing the Leontopodic acid in treating hepatitis. The leontopodic acid and the plant extract and the composition containing the leontopodic acid have obvious effects on resisting hepatitis virus, resisting inflammation, protecting the liver and regulating immunity, and can be used for treating hepatitis.

The invention relates to a traditional Chinese medicine composition for treating traumatic injury and a preparation method and a quality control method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from six traditional Chinese medicines of pseudo-ginseng, ligusticum wallichii, radix angelicae, Angelica sinensis, ground beeltle and safflower carthamus; the medicine has the effects of promoting blood circulation to arrest pain and eliminating blood stasis and promoting tissue regeneration, and is mainly used to treat traumatic injury, blood stasis and swelling of muscles and bones, rheumatism and numbness. The traditional Chinese medicine composition is advanced in process, high in content of effective elements, remarkable in test effect of clinical pharmacodynamics, and high in bioavailability, and has no toxic and side effects.

The invention relates to a traditional Chinese medicine composition used for treating coronary heart disease and cerebral arteriosclerosis, and a preparation method thereof. The traditional Chinese medicine composition is prepared from ten traditional Chinese medicines of mongolian milkvetch root, salvia miltiorrhiza, desertliving cistanche herb, wenchow turmeric root tuber, szechwan lovage rhizome, hawthorn, siberian solomonseal rhizome, ginkgo seed, rhubarb, and lumbricus. The traditional Chinese medicine composition provides functions of vital energy benefiting, blood circulation activating, spleen strengthening, and collaterals dredging. The traditional Chinese medicine composition is mainly used in the auxiliary treatment of Qi deficiency and blood stasis syndromes caused by coronaryheart disease and cerebral arteriosclerosis. Compared to prior arts, the clinical pharmacodynamical test effects of the traditional Chinese medicine composition are substantially improved, the bioavailability of the traditional Chinese medicine composition is high, and the traditional Chinese medicine composition brings no toxic or side-effect.

The invention relates to a traditional Chinese medicine composition with functions of warming kidney and invigorating yang, and its preparation method. The traditional Chinese medicine composition comprises the following traditional Chinese medicines by weight part: 300-700 parts of epimedium, 300-700 parts of Curculigo orchioides, 200-600 parts of fructus ligustri lucidi, 200-600 parts of red sage root, 30-70 parts of gen-seng, 30-70 parts of pilose antler, 150-400 parts of Radix polygoni multiflori preparata and 10-40 parts of leech. The above traditional Chinese medicine composition has strong improvement effects for each index of animals with yang insufficiency and various symptoms of low immunity function, and has no obvious influence on normal animals, especially has small influence on the viscera organs. The traditional Chinese medicine composition has no toxicity and side-effect.

The invention relates to a throat stagnation eliminating Chinese medicinal composition and a preparation method thereof. The Chinese medicinal composition is prepared from sixteen traditional Chinese medicines, including puffball, vinegar-treated curcuma zedoary, honeysuckle flower, water-boiled peach kernel, figwort, vinegar-treated common burreed rhizome, safflower, red-rooted salvia root, isatis root, dwarf lilyturf root, thunberg fritillary bulb, oriental waterplantain rhizome, cicada shell, fried chicken gizzard membrane, indian trum etflower seed and dandelion, has the effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm, and is mainly used for treating hoarseness, injection ofvocal cord and swelling caused by accumulation of toxic heat and qi depression to blood stasis, chronic laryngitis, vocal nodule and polyp of vocal cord. The clinical pharmacodynamic study effect of the Chinese medicinal composition is enhanced remarkably, and the Chinese medicinal composition does not have any toxic or side effect.

The invention relates to a traditional Chinese medicine composition for treating chronic hepatitis and a preparation method thereof. The traditional Chinese medicine composition is characterized in that four traditional Chinese medicines, namely Chinese magnoliavine fruit extract, baicalin, licorice extract, mulberry radix salviae miltiorrhizae extract are processed to prepare the composition. The traditional Chinese medicine composition has the efficacies of clearing heat, detoxicating, activating blood circulation to dissipate blood stasis, protecting the liver, regulating the spleen, and reducing aminotransferase, is mainly used for treating persistent and chronic hepatitis, has remarkable clinical pharmacodynamic testing effect, is high in bioavailability, and has not any toxic or side effect.

The invention relates to the application of volatile oil of water caltrops in preparing tumor-inhibiting drugs, belonging to field of Chinese herbal medicine. The volatile oil of water caltrops can be get through the method reported by prior document and also can be get through preferred supercritical fluid extraction method. The volatile oil of water caltrops has the advantages of obvious inhibition function upon growth and proliferation of tumor cell, obvious inhibition function upon cervical cancer and liver cancer through pharmacodynamics experiment showing without obvious toxic reaction.

The transfused gingko leaf liquid is prepared with the materials including gingko leaf, absolute alcohol, povidone K30, sodium chloride, antioxidant and injection water and no sorbierite. During itspreparation, gingko leaf extract is first extracted with gingko leaf and through hot soaking, filtering, column refining and other steps and then mixed with other materials. The transfused gingko leaf liquid can improve body's blood circulation, dilute coronary artery and cerebral artery and may be used in treating coronary heart disease, angina pectoris, cerebral thrombus, cerebral malfunction,ischemic cerebral apoplexy, etc. and improving the perception function of senile dementia and vascular dementia patients.

The invention relates to a traditional Chinese medicine composition for treating lumbar intervertebral disc herniation and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following 13 traditional Chinese medicines: pseudo-ginseng, safflower, draconis resin, ground beetle, rhizoma drynariae, rhubarb root and rhizome, frankincense, myrrh, ephedra, native copper, white paeony root processed with wine, Chinese angelica processed with wine and medicated leaven. The composition has the functions of promoting blood circulation to remove blood stasis and activating meridians to stop pain, and is mainly used for treating symptoms caused by blood stasis type lumbar intervertebral disc herniation such as lumbago and the like. Compared with the prior art, the composition has the advantages of reasonable component, high active ingredient content, obviously improved clinical pharmacodynamic test effect, high bioavailability and no toxic or side effect.

The invention relates to a Chinese medicinal composition having effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm and a preparation method thereof. The Chinese medicinal composition is prepared from sixteen traditional Chinese medicines, including puffball, vinegar-treated curcuma zedoary, honeysuckle flower, water-boiled peach kernel, figwort, vinegar-treated common burreed rhizome, safflower, red-rooted salvia root, isatis root, dwarf lilyturf root, thunberg fritillary bulb, oriental waterplantain rhizome, cicada shell, fried chicken gizzard membrane, indian trum etflower seed and dandelion, has the effects of clearing away heat and toxic materials, promoting blood circulation by removing blood stasis, removing dampness through diuresis and reducing phlegm, and is mainly used for treating hoarseness, injection of vocal cord and swelling caused by accumulation of toxic heat and qi depression to blood stasis, chronic laryngitis, vocal nodule and polyp of vocal cord. The clinical pharmacodynamic study effect of the Chinese medicinal composition is enhanced remarkably, and the Chinese medicinal composition does not have any toxic or side effect.

The invention relates to a traditional Chinese medicine composition for treating upper respiratory tract infection and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 400-500 parts of dandelion, 200-300 parts of baikal skullcap root, 500-800 parts of radix sileris, 300-600 parts of balloon flower, 200-300 parts of bupleurum, 150-200 parts of bulbus fritillariae cirrhosae, 300-400 parts of cape jasmine, 100-200 parts of forsythia and 100-200 parts of licorice. The traditional Chinese medicine composition has the effects of clearing away heat and toxic materials, dispersing pathogenic wind, resolving phlegm and relieving cough, eliminating stagnation and removing stasis as well as eliminating swelling and alleviating pain, and also can meet the requirements on safe use, small taking dose, convenient carrying and high effect taking speed.